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Total 1725 results found since Jan 2013.
Predicting drug-target binding affinity through molecule representation block based on multi-head attention and skip connection
Brief Bioinform. 2022 Nov 19;23(6):bbac468. doi: 10.1093/bib/bbac468.ABSTRACTExiting computational models for drug-target binding affinity prediction have much room for improvement in prediction accuracy, robustness and generalization ability. Most deep learning models lack interpretability analysis and few studies provide application examples. Based on these observations, we presented a novel model named Molecule Representation Block-based Drug-Target binding Affinity prediction (MRBDTA). MRBDTA is composed of embedding and positional encoding, molecule representation block and interaction learning module. The advantages ...
Source: Briefings in Bioinformatics - November 22, 2022 Category: Bioinformatics Authors: Li Zhang Chun-Chun Wang Xing Chen Source Type: research
Kineret authorized for emergency use by FDA for the treatment of COVID-19 related pneumonia
STOCKHOLM, Nov. 10, 2022. Sobi today announced that the US Food and Drug Administration has granted Emergency Use Authorization (EUA) for the use of Kineret® (anakinra) for the treatment of coronavirus disease 2019 (COVID-19) in hospitalized...
Source: Drugs.com - Clinical Trials - November 10, 2022 Category: Pharmaceuticals Source Type: clinical trials
Scientists say eye-disease drug may also help fight COVID
FINDINGSAn interdisciplinary research team led by UCLA found that a drug already approved by the Food and Drug Administration for eye disease, verteporfin, stopped the replication of SARS-CoV-2, the virus that causes COVID-19. Their laboratory study identified the Hippo signaling pathway as a potential target for therapies against the coronavirus.BACKGROUNDMany important human biological processes are controlled by complicated chain reactions called signaling pathways, in which certain proteins act as messenger molecules that promote or block the signals of other proteins.The lead researchers were investigating the Hippo...
Source: UCLA Newsroom: Health Sciences - November 8, 2022 Category: Universities & Medical Training Source Type: news
Bivalent COVID-19 Boosters Rev Up Protection, Pfizer Study Says
Pfizer’s updated COVID-19 booster significantly revved up adults’ virus-fighting antibodies, the company said Friday, releasing early findings from a rigorous study of the new shots.
Booster doses tweaked to target the most common Omicron strain rolled out in early September, and the Food and Drug Administration said the latest data should spur more Americans to get one—especially before another expected wave of cases as people travel for Thanksgiving.
Pfizer said people 55 and older who got the Omicron-targeting booster had four-fold higher antibody levels than those given an extra dose of the original v...
Source: TIME: Health - November 4, 2022 Category: Consumer Health News Authors: LAURAN NEERGAARD/AP Tags: Uncategorized COVID-19 healthscienceclimate wire Source Type: news
News at a glance: Earth ’s top geological sites, cameras on sharks, and China’s space station
NATURAL HISTORY
Science society lists Earth’s top ‘geoheritage’ sites
The International Union of Geological Sciences last week marked its 60th anniversary by announcing
a list of 100 “geoheritage” sites that have substantially influenced understanding of Earth’s deep history
. The global list, released in collaboration with UNESCO, is meant to foster conservation and tourism. The sites include familiar ones, such as the Grand Canyon’s “great unconformity,” a billion-year gap in the rock record erased by erosion. More exotic examples include limestones in Germany that preserve
Arc...
Source: Science of Aging Knowledge Environment - November 3, 2022 Category: Geriatrics Source Type: research
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
by Pinar Mesci, Janaina S. de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W. Adams, Simoni H. Avansini, Roberto H. Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A. Szeto, Gabriela Goldberg, Patrick T. Bruck, Fabio Papes, Sumit K. Chanda, Alysson R. Muotri
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology focused mainly on respiratory illnesses. However, a variety of neurological manifestations in...
Source: PLoS Biology: Archived Table of Contents - November 3, 2022 Category: Biology Authors: Pinar Mesci Source Type: research
Doctors Warn FDA of Risks Posed by Flawed Oxygen Devices
Especially for Black patients, inaccurate readings have imperiled care and may have contributed to deaths during the pandemic, experts told an advisory panel.
Source: NYT Health - November 2, 2022 Category: Consumer Health News Authors: Christina Jewett Tags: Coronavirus (2019-nCoV) Deaths (Fatalities) Black People Doctors Research Oxygen Pulse Oximetry Skin Medical Devices Regulation and Deregulation of Industry Food and Drug Administration Source Type: news
‘Extremely satisfying’: Scientist’s insight powers new RSV vaccine for infants
Barney Graham, a former scientist at the U.S. National Institute of Allergy and Infectious Diseases (NIAID), was thrilled yesterday when
Pfizer announced encouraging results
from an experimental vaccine that could protect against a major childhood killer. In a press release, the company said immunizing pregnant women
*
with its vaccine against respiratory syncytial virus (RSV) protected their babies from severe disease for 6 months. If the full results of its clinical trial bear out that promise, the vaccine could spare millions of infants worldwide from RSV-related hospitalization, reduce lasting lung damage f...
Source: Science of Aging Knowledge Environment - November 2, 2022 Category: Geriatrics Source Type: research
Chewing to curb COVID
Penn Medicine will conduct a new clinical trial to evaluate the safety and efficacy of a chewing gum designed by School of Dental Medicine researchers to trap SARS-CoV-2 in the saliva. Chewing gum tablets containing plant material laced with the ACE2 protein are being evaluated in a clinical trial to see if they are safe and effective in trapping SARS-CoV-2 in the saliva. (Image: Kevin Monko/Penn Dental Medicine) A recently launched clinical trial at Penn Medicine will evaluate a new chewing gum designed by School of Dental Medicine researchers to trap SARS-CoV-2 in the saliva, potentially blocking transmission of COVID-19...
Source: Dental Technology Blog - November 2, 2022 Category: Dentistry Source Type: news
Popular Dry Shampoos Found to Have Cancer-Causing Chemical
Top-selling dry shampoos including Not Your Mother’s and Church & Dwight Co.’s Batiste contain high levels of benzene, the cancer-causing chemical that led Unilever to yank its product from shelves in October, according to a new independent study.
Valisure, a New Haven, Connecticut-based analytical laboratory, tested 148 batches from 34 brands of spray-on dry shampoo and found that 70% contained benzene. The chemical can cause certain blood cancers, such as leukemia. The company filed a petition Monday with the U.S. Food and Drug Administration seeking to have the products that contain the substance recalle...
Source: TIME: Health - November 2, 2022 Category: Consumer Health News Authors: Anna Edney/Bloomberg Tags: Uncategorized healthscienceclimate Public Health wire Source Type: news
Roche receives FDA clearance for COVID-19 PCR test for use on cobas 6800/8800 Systems
The cobas SARS-CoV-2 Qualitative test is one of the first COVID-19 PCR tests performed on an automated, high throughput platform to receive FDA 510(k) clearance.This FDA clearance will ensure that the healthcare community has access to timely, reliable and accurate COVID-19 PCR testing beyond the EUA period.Based on continuous analysis performed since the onset of the pandemic, all Roche molecular tests, including the cobas SARS-CoV-2 Qualitative test, detect all SARS-CoV-2 variants. Basel, 24 October 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has granted...
Source: Roche Investor Update - October 24, 2022 Category: Pharmaceuticals Source Type: news
When Will Novavax Vaccines Be FDA Authorized As Covid-19 Boosters?
It ’s been nearly two months since Novavax submitted a emergency use authorization (EUA) application to the U.S. Food and Drug Administration (FDA) for Nuvaxovid to be used as a booster.
Source: Forbes.com Healthcare News - October 13, 2022 Category: Pharmaceuticals Authors: Bruce Y. Lee, Senior Contributor Tags: Healthcare /healthcare Innovation /innovation Science /science Coronavirus business pharma Source Type: news
FDA Authorizes Updated Covid Booster Shots For Kids 5 to 11
Regulators authorized the shots for older age groups in late August, but much of the general population appears either unaware or uninterested in them.
Source: NYT - October 12, 2022 Category: American Health Authors: Sharon LaFraniere Tags: Coronavirus (2019-nCoV) Vaccination and Immunization Children and Childhood Food and Drug Administration Pfizer Inc BioNTech SE Moderna Inc United States Politics and Government Source Type: news
