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Specialty: Biochemistry
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Total 109410 results found since Jan 2013.
Silencing lncRNA EZR ‑AS1 induces apoptosis and attenuates the malignant properties of lung adenocarcinoma cells
This study aimed to investigate the effect of silencing long non-coding RNA (lncRNA) EZR‑AS1 on the biological behaviors of lung adenocarcinoma (ADC) cells. EZR‑AS1 expression levels in lung ADC tissues and cells, as well as in adjacent non-cancerous tissues, were determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). EZR‑AS1 was knocked down in two lung ADC cell lines using small interfering RNA specific for EZR‑AS1 (siEZR‑AS1). Proliferation, migration, and apoptosis of EZR‑AS1-knockdown cells were assessed using the CCK-8 viability assay, flow cytometry, or wound healing exp...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Xianjing Yu Lixue Wu Zhongcui Lu Junli Zhang Yunfeng Zhou Source Type: research
NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species
Acta Biochim Pol. 2023 Sep 18;70(3):685-692. doi: 10.18388/abp.2020_6580.ABSTRACTNicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is an enzyme that regulates reactive oxygen species (ROS) generation, and its function in the development of chondrosarcoma remains unclear. In the present study, we studied NOX4 expression in chondrosarcoma by immunochemical examination, and analyzed the role of NOX4 in viability and apoptosis of human chondrosarcoma cell line SW1353 using NOX4 siRNA or NOX4 inhibitor GKT137831. NOX4 level significantly increased in tumor compared to that in para-carcinoma sample. The levels of NOX4...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Zheng Jun Wang Lei Fang Ce Ren Wen Tao Meng Xiang Hui Qing Ci Nan Source Type: research
Circ-PGPEP1 augments renal cell carcinoma proliferation, Warburg effect, and distant metastasis
This study probed the molecular mechanism of circPGPEP1 regulating RCC proliferation, Warburg effect, and distant metastasis by targeting the miR-378a-3p/JPT1 axis. Here identified higher circPGPEP1 expression in RCC tissues and cells by RT-qPCR, and high levels of circPGPEP1 were positively correlated with high histological grade and distant metastasis in RCC patients. Furthermore, patients with high levels of circPGPEP1 had a worse survival prognosis. Functional assays presented that knockdown of circPGPEP1 inhibited RCC proliferation, invasion, migration, EMT, and Warburg effect. Dual-luciferase reporter assay, RNA immu...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: PeiRui Wang Jin Chen Xin Ye RuYi Wang Lin Chen HanChao Zhang Source Type: research
Biomass-based indole derived fluorescence sensor composited with cellulose paper: Detection of picric acid in food and environment samples
Int J Biol Macromol. 2023 Sep 16:126963. doi: 10.1016/j.ijbiomac.2023.126963. Online ahead of print.ABSTRACTPicric acid (PA) is highly water-soluble, the fact makes it stand out as the most hazardous environment pollutant. Therefore, accurate determination of PA is of great significance for human health and environmental protection. Herein, a novel indole-based fluorescent sensor (H1) with good water solubility and fluorescence stability was reported. H1 exhibited 'turn-off' fluorescence response for PA with fast reaction rate (<30 s), unique specificity and excellent selectivity and high sensitivity (limit of detection...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Yingying Zhang Xiaoci Cui Xin Wang Xiuyuan Feng Weixia Cheng Ranhua Xiong Chaobo Huang Source Type: research
Synthesis of chitosan-based perylene dye material for photovoltaic solar-cell application
This study proposes a novel chitosan biopolymer-based perylene dye; the dye is modified by chitosan with perylene-3,4,9,10-tetracarboxylic anhydride using a one-pot acylation of nitrogen nucleophiles for DSSCs. The chitosan biopolymer-based perylene dyes were characterized using attenuated total reflection infrared spectroscopy, solid-state 13C CP-TOSS nuclear magnetic resonance spectroscopy, X-ray powder diffraction analysis, thermogravimetric analysis, X-ray photoelectron spectrometry, and high-resolution field-emission scanning electron microscopy. The ultraviolet-visible and fluorescence spectroscopy of chitosan biopol...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Santosh Kumar Ira Singh Nazrul Hsan Bhabani Sankar Swain Joonseok Koh Source Type: research
Emerging roles of biological m < sup > 6 < /sup > A proteins in regulating virus infection: A review
Int J Biol Macromol. 2023 Sep 16:126934. doi: 10.1016/j.ijbiomac.2023.126934. Online ahead of print.ABSTRACTN6-methyladenosine (m6A) is the most prevalent chemical modifications of intracellular RNA, which recently emerging as a multifaceted effector of viral genomic RNA. As a dynamic process, three groups of biological proteins control the levels of m6A modification in eukaryocyte, designed as m6A writers, erasers, and readers. The m6A writers comprising of methyltransferases complex initiate the modification process. On the contrary, the m6A erasers ALKBH5 or FTO abolish the modification through three-step demethylation:...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Yuran Chen Wenjing Wang Wuchao Zhang Mei He Yuming Li Guosheng Qu Jie Tong Source Type: research
Structural variations of lignin and lignin-carbohydrate complexes from the fruit shells of Camellia oleifera during ripening
Int J Biol Macromol. 2023 Sep 16:126946. doi: 10.1016/j.ijbiomac.2023.126946. Online ahead of print.ABSTRACTCamellia oleifera fruit shell (CFS), a waste lignocellulosic biomass resulting from Camellia oleifera oil production industry, is abundantly available in Southern China. Herein, to understand the structural variations of CFS lignins and lignin-carbohydrate complexes (LCC) during ripening, the native lignin and LCC fractions from CFS (harvested every seven days from October 1 to 30, 2022) were isolated and characterized systematically. The molecular weights of both MWL and DEL fractions steadily increased during ripen...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xichuang Cheng Ruxia Ning Pengfei Li Fenglun Zhang Kun Wang Jianxin Jiang Source Type: research
Nanopeptide CI20 remarkably enhances growth performance and disease resistances by improving the mucosal structure, antioxidant capacity, and immunity in mandarin fish (Siniperca chuatsi)
In this study, the nanopeptide CI20, which was created by conjugating antimicrobial peptide gcIFN-20H and CMCS, were evaluated the feeding effect in mandarin fish (Siniperca chuatsi). Compared with the control group, 150 mg/kg C-I20-fed fish showed the second highest growth performance with no significant changes in body composition. C-I20-fed fish showed more goblet cells and thicker mucin after feeding. The 150 mg/kg CI20 diet boosted the antioxidant capacity, immunity, and digestive enzymes. After Aeromonas hydrophila and infection spleen and kidney necrosis virus infection, the survival rates in the 150 mg/kg CI20 grou...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xingchen Huo Jiao Chang Qiwei Zhang Weicheng Wang Pengxu Wang Fengxia Zhao Shan He Chunrong Yang Xiaoling Liu Xufang Liang Yongan Zhang Jianguo Su Source Type: research
Bacterial cellulose/gum Arabic composite production by in-situ modification from lavender residue hydrolysate
In this study, bacterial cellulose/gum Arabic composite (BC/GA) was synthesized by in-situ modification from lavender residue hydrolysate for the first time. The in-situ modification with GA adding showed great beneficial effect for BC/GA synthesis. Both the product (BC or BC/GA) yield and the product (BC or BC/GA) production per sugars consumption increased greatly by the in-situ modification when compared with the fermentation without GA adding (2.90 g/L vs. 0.91 g/L, and 0.461 g/g vs. 0.138 g/g). It is hypothesized that the combination of BC and GA is the main mechanism for the beneficial effect of the in-situ modificat...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Huai-Peng Jia Xiao-Lin Wang Zhuo-Wei Liu Yi Wu Jing Gao Yong Hu Yun Chen Chao Huang Source Type: research
Investigation on the inhibition mechanism and binding behavior of paeonol to tyrosinase and its anti-browning property by multi-spectroscopic and molecular docking methods
In this study, the inhibition mechanism and binding behavior of paeonol to tyrosinase and its anti-browning property were investigated using multi-spectroscopic and molecular docking methods. Activity assay and kinetic results confirmed paeonol as a reversible mixed-type tyrosinase inhibitor. Results of the mechanistic studies were clarified using fluorescence quenching, synchronous fluorescence, CD spectra and 3D fluorescence, and showed that the binding of paeonol to tyrosinase might change the chromophore microenvironment and conformation of tyrosinase to inhibit enzyme catalytic activity. Molecular docking results reve...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiaofeng Min Li Lu Xuetao Xu Yi Wen Xi Zheng Source Type: research
Genome-wide identification, evolution and expression of TGF- β signaling pathway members in mandarin fish (Siniperca chuatsi)
Int J Biol Macromol. 2023 Sep 16:126949. doi: 10.1016/j.ijbiomac.2023.126949. Online ahead of print.ABSTRACTMembers of the transforming growth factor β (TGF-β) signaling pathway regulate diverse cellular biological processes in embryonic and tissue development. We took mandarin fish (Siniperca chuatsi) as the research object to identify all members of the TGF-β signaling pathway, measure their expression pattern in the key period post hatching, and further explore their possible role in the process of sex regulation. Herein, we identified eighty-three TGF-β signaling pathway members and located them on chromosomes base...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Shiyan Liu Chong Han Jingjun Huang Meihui Li Jiayu Yang Guifeng Li Haoran Lin Shuisheng Li Yong Zhang Source Type: research
Fabrication of Ru loaded MgB < sub > 2 < /sub > with guar gum hybrid for photocatalytic degradation of crystal violet
Int J Biol Macromol. 2023 Sep 16:126948. doi: 10.1016/j.ijbiomac.2023.126948. Online ahead of print.ABSTRACTToday, dyes/pigment-based materials are confronting a serious issue in harming marine ecology. Annihilate these serious water pollutants using photoactive 2D nanohybrid catalysts showed promising comparativeness over available photocatalysts. In the present work, a facile route to decorate Ruthenium (Ru) on 2D MgB2 flower-like nanostructures was developed via ecofriendly guar gum biopolymer substantial template (MgB2/GG@Ru NFS) and its photocatalytic performance was reported. Synthesis of MgB2@Ru, MgB2/GG@Ru NFS and ...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Ramasubba Reddy Palem Chinna Bathula Ganesh Shimoga Soo-Hong Lee Ayman A Ghfar Sankar Sekar Hyun-Seok Kim Young-Soo Seo Iqra Rabani Source Type: research
Mammalian odorant-binding proteins are prone to form amorphous aggregates and amyloid fibrils
Int J Biol Macromol. 2023 Sep 16:126872. doi: 10.1016/j.ijbiomac.2023.126872. Online ahead of print.ABSTRACTOdorant-binding proteins are involved in perceiving smell by capturing odorants within the protein's β-barrel. On the example of bovine odorant-binding protein (bOBP), the structural organization of such proteins and their ability to bind ligands under various conditions in vitro were examined. We found a tendency of bOBP to form oligomers and small amorphous aggregates without disturbing the integrity of protein monomers at physiological conditions. Changes in environmental parameters (increased temperature and pH)...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Olga V Stepanenko Anna I Sulatskaya Maksim I Sulatsky Ekaterina V Mikhailova Irina M Kuznetsova Konstantin K Turoverov Olesya V Stepanenko Source Type: research
Carboxymethyl konjac glucomannan-chitosan complex nanogels stabilized emulsions incorporated into alginate as microcapsule matrix for intestinal-targeted delivery of probiotics: In vivo and in vitro studies
In this study, we developed a novel delivery system using carboxymethyl konjac glucomannan-chitosan (CMKGM-CS) nanogels stabilized single and double emulsion incorporated into alginate hydrogel as microcapsule matrix for intestinal-targeted delivery of probiotics. Through in vitro experiments, it was demonstrated that alginate hydrogel provided favorable biocompatible growth conditions for the proliferation of Lactobacillus reuteri (LR). The alginate hydrogel containing single (ASE) or double emulsions (ACG) enhanced the resistance of LR to various adverse environments. Simulated gastrointestinal digestion experiments reve...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiaoqing Ding Danlei Li Yibin Xu Yuanyuan Wang Shuang Liang Lingyu Xie Weiqiang Yu Xiuan Zhan Aikun Fu Source Type: research
Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications
In this study, porous bacterial levan-based sponges containing cannabis oil (Lev@CBDs) were prepared and fully characterized. The sponges exhibited a suitable swelling ratio, proper water vapor transmission rate, sufficient thermal stability, desired mechanical properties, and good antioxidant and anti-inflammatory properties. The obtained Lev@CBD materials were evaluated in terms of their interaction with proteins, human serum albumin and fibrinogen, of which fibrinogen revealed the highest binding effect. Moreover, the obtained biomaterials exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas ae...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Dorota Chelminiak-Dudkiewicz Miloslav Machacek Jolanta Dlugaszewska Magdalena Wujak Aleksander Smolarkiewicz-Wyczachowski Szymon Bocian Kinga Mylkie T Goslinski Michal P Marszall Marta Ziegler-Borowska Source Type: research
