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Source: Current Treatment Options in Allergy

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Total 345 results found since Jan 2013.

Food Allergy and Asthma: Is There a Link?
AbstractPurpose of reviewTo describe and understand the links and interactions between food allergy and asthmaRecent findingsFood allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Both conditions are associated with each other in different ways. It has been shown that food allergy is a risk factor of developing asthma. Atopic dermatitis appears to be the common denominator in this interaction. Loss-of-function variants of the filaggrin mutation result in an impaired epidermal barrier function and have been shown to be a risk factor for the development of atop...
Source: Current Treatment Options in Allergy - October 1, 2018 Category: Allergy & Immunology Source Type: research

Component-Resolved and Complementary Tests in the Diagnosis of Occupational Allergy: Advantages and Limitations
Opinion StatementEnhancing the repertoire of in vitro methods together with the development of recombinant technology in the field of allergy diagnosis brought tremendous advances in understanding allergens, allergic reactions, and patients ’ care. This review is focusing not only on component-resolved diagnosis with occupational allergens, complementary methods, their advantages to improve the in vitro diagnosis for occupational allergy but also their limitations. Up to now, the number of occupational asthma sensitizers characterize d on the molecular level and their availability for routine diagnosis is very low. One e...
Source: Current Treatment Options in Allergy - May 6, 2017 Category: Allergy & Immunology Source Type: research

Patients ’ Perspectives and Needs on Novel Food Allergy Treatments in the United States
AbstractPurposeFood allergy management places a daily psychosocial burden on patients and their caregivers. New food allergy treatments may positively impact their lives, but also introduce new stressors. The purpose of this paper is to provide an overview of the current state of the literature regarding patients ’ and caregivers’ food allergy experiences and needs within the United States as well as a set of recommendations regarding how best to proceed with patient-centered development and evaluation of new food allergy treatments.Recent findingsThe first pharmaceutical-grade product for peanut oral immunotherapy was...
Source: Current Treatment Options in Allergy - January 23, 2021 Category: Allergy & Immunology Source Type: research

Risk stratification in beta-lactam allergy
AbstractPurpose of ReviewBeta-lactams (BLs) are among the most commonly prescribed and effective antibiotics. Given the fact that overdiagnosis of penicillin allergy constitutes a major public health problem by increasing health costs and contributing to overall antibiotic resistance, removing BL allergy label is crucial.Recent FindingsDelabeling penicillin allergy as an essential component of antimicrobial stewardship is a hot topic. Despite several clinical risk factors and genetic characteristics proposed to predict BL allergy, it is still unclear what exactly constitutes a risk. Recently, a great deal of interest has b...
Source: Current Treatment Options in Allergy - October 16, 2021 Category: Allergy & Immunology Source Type: research

Do No Harm: Risk vs. Benefit of the Approach to Childhood Food Allergy
Opinion statementThe prevalence of food allergy is rising across much of the world, but the rate of fatal food anaphylaxis appears generally stable. Given the negligible impact on overall mortality risk from fatal food anaphylaxis in children, probable overdiagnosis of food allergy, and the large psychosocial burden caused by this disease, we aim to reassure patients, families, and allergists regarding risk and propose solutions to improve the current approach to childhood food allergy. Data suggests that children labelled food allergic and their parents frequently overestimate their food allergy risk, leading to excessive...
Source: Current Treatment Options in Allergy - October 26, 2022 Category: Allergy & Immunology Source Type: research

Fragrance and Cosmetic Contact Allergy in Children
Opinion statement A consensual definition of childhood must be established concerning contact allergy. Little is known about contact allergy to fragrances and cosmetic products in children. Thus, contact allergy is under-recognized. Fragrances are one of the main causes of allergic contact dermatitis. Recently, French cosmetovigilance has shown that cosmetic contact allergy is frequently diagnosed as allergic contact dermatitis but also in some cases as urticaria. Children have to be tested when they suffer from contact urticaria or eczema, whatever their age. The etiological treatment is always to avoid the alle...
Source: Current Treatment Options in Allergy - September 1, 2014 Category: Allergy & Immunology Source Type: research

Basophil Activation Test in IgE-Mediated Food Allergy: Should We Follow the Flow?
Opinion statement IgE-mediated food allergy constitutes an important and increasing health issue with significant impairment of quality of life and significant morbidity and mortality. It affects children, as well as adolescents, and adults. Correct diagnosis of food allergy relies upon history supplemented by quantification of specific IgE (sIgE) antibodies and/or skin tests. Unfortunately, as these tests do not demonstrate absolute predictive values, controlled oral provocation tests might be needed to confirm/exclude diagnosis. However, it is unlikely oral challenges to enter mainstream application, mainly beca...
Source: Current Treatment Options in Allergy - March 30, 2016 Category: Allergy & Immunology Source Type: research

The Impact of Corticosteroid Allergy
Opinion statement The key to treatment of corticosteroid allergy, especially delayed-type reactions to topical corticosteroids, is in recognizing it as a possible diagnosis. Corticosteroids are among the most important anti-inflammatory agents in a physician’s therapeutic armamentarium; these medications are the cornerstone of treatment for most dermatoses and may be overlooked as the culprit in cases of refractory dermatitis. Clues to possible corticosteroid allergy include persistence or worsening of dermatitis with the use of an appropriate agent or a change in the clinical pattern of disease. Patients may ne...
Source: Current Treatment Options in Allergy - July 8, 2016 Category: Allergy & Immunology Source Type: research

Precision Medicine in the Management of Drug Allergy
AbstractPurpose of studyThe term precision medicine has been developed in the last five or more years to describe the concept of treating patients individually based on a variety of factors. Precision medicine can be applied to the field of drug allergy where phenotypes, endotypes, and biomarkers have been defined.Recent findingsPhenotypes of drug allergy can be based on (1) the mechanism of the underlying reaction; (2) the clinical presentation of the reaction; and (3) the timing of the reaction in regards to exposure to the drug. Endotypes of drug allergy can be defined based on mechanisms, pharmacologic processes, and h...
Source: Current Treatment Options in Allergy - February 15, 2018 Category: Allergy & Immunology Source Type: research

De-labeling Penicillin Allergy in Pediatric Population
AbstractPurpose of review At present, penicillin allergy in children is misdiagnosed, leading to undesirable health consequences; thus, a correct diagnosis is needed. De-labelling penicillin allergy strategies in pediatric population is emerging in order to achieve a correct antimicrobial management.Recent findingsNew protocols, specific for pediatric population, are rising from academic societies in order to improve penicillin allergy management in children, so unnecessary tests are avoided.SummaryThis document aims to provide guidance on how to de-label penicillin allergy in children through a correct diagnosis. The wo...
Source: Current Treatment Options in Allergy - August 5, 2022 Category: Allergy & Immunology Source Type: research

Early Introduction of Foods for Food Allergy Prevention
Opinion statement The identification of food allergy prevention strategies has become an important public health issue given the increase in hospital presentations for food allergic reactions in young children. In particular, there has been an increasing interest in whether the timing of introduction of solids (particularly allergenic solids such as egg and peanuts) plays a role in development of early-onset food allergy. To date, research in the area has primarily been limited to observational birth cohort studies, which have generated data to suggest that delayed introduction of allergenic solids may actually i...
Source: Current Treatment Options in Allergy - June 1, 2014 Category: Allergy & Immunology Source Type: research

The Economic Burden of Food Allergy: What We Know and What We Need to Learn
AbstractPurpose of ReviewFood allergy management and treatment require dietary modification, are associated with significant burdens, and affect food choices and behaviours. Emerging therapies, such as oral immunotherapy (OIT), provide a glimmer of hope for those living with the condition. Some burdens have received substantial focus, whereas many knowledge gaps on the significance of other impacts, including economic burden, remain.Recent FindingsEvidence from many countries, but disproportionately from the United States, supports that food allergy carries significant healthcare and societal costs. Early introduction for ...
Source: Current Treatment Options in Allergy - April 28, 2022 Category: Allergy & Immunology Source Type: research

Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes
AbstractPurpose of reviewIn the recent years, more cases of poultry meat allergy, both IgE- or non-IgE-mediated, are being reported. Patients have varied clinical reactivity at various levels of sensitivity to different meat preparations. The lack of validated biomarkers renders accurate diagnosis challenging. In this review, we aim to provide an overview of the current status of poultry meat allergy along with a description on the allergens implicated.Recent findingsPoultry meat allergy occurs as a result of cross-reactions with known allergens of egg yolk or bird feathers or as genuine IgE-mediated sensitivity to allerge...
Source: Current Treatment Options in Allergy - June 27, 2022 Category: Allergy & Immunology Source Type: research

The Potential of Anti-IgE in Food Allergy Therapy
Opinion statement Food allergy is an inappropriate immune response to certain food components. With its increasing prevalence over the past two decades, and potentially fatal consequences, food allergy has become a formidable public health issue. There is currently no effective therapy to treat food allergy. Patients are compelled to resort to strict avoidance of allergenic foods, and they must have quick access to emergency care in the event of accidental exposure. Clearly, there is an urgent need for treatment options. Allergen-specific and allergen-nonspecific therapeutic measures are being actively explored t...
Source: Current Treatment Options in Allergy - June 1, 2014 Category: Allergy & Immunology Source Type: research