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Cancer: Squamous Cell Carcinoma
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Total 19037 results found since Jan 2013.
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma
This study aimed to investigate the function of miR-5189-3p in laryngeal squamous cell carcinoma (LSCC) and explore its underlying mechanisms. qRT-PCR was designed to determine the expression levels of miR-5189-3p and eukaryotic translation initiation factor 5A2 (EIF5A2), while CCK-8 assay was performed to measure the effects of miR-5189-3p on cell proliferation. Transwell assay was performed to evaluate cell invasion as well as migration, and wound healing assay was applied to demonstrate cell migratory ability. Target gene prediction and luciferase reporter assay were developed to screen the possible target gene of miR-5...
Source: Biochemical Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Dan Lou Qiaojing Jia Haizhong Zhang Jingmiao Wang Lisha Liu Zhichang Liu Xiaofang Jia Jianxing Wang Chunguang Shan Source Type: research
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research
Non eosinophilic chronic stricturing esophagitis: lessons from thirty eight cases
CONCLUSION: The management of non-eosinophilic chronic stricturing esophagitis is challenging, because of a low contribution of esophageal biopsies and the refractory nature of the strictures. In our experience, a dermatological evaluation helped in 55% of cases to introduce a systemic treatment, leading to limit the use of endoscopic dilatation. Endoscopic follow-up is needed, considering the significant risk of esophageal squamous cell carcinoma.PMID:37657720 | DOI:10.1016/j.clinre.2023.102202
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Flavius-Stefan Marin Antoine Assaf Sarra Oumrani Vannina Seta Marianne Gaudric Fr édéric Beuvon Arthur Belle Romain Coriat Nicolas Dupin Stanislas Chaussade Maximilien Barret Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes
This study revealed that the previously observed hypermethylation of HPV(+) HNSCC is due solely to the IMU subtype, illustrating the importance of fine-scale subtype analysis in such a heterogeneous disease. Particularly, IMU has significantly higher methylation of transposable elements, which can be tested as a prognosis biomarker in future translational studies.PMID:37654626 | PMC:PMC10467604 | DOI:10.1158/2767-9764.CRC-23-0009
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Tingting Qin Shiting Li Leanne E Henry Elysia Chou Raymond G Cavalcante Bailey F Garb Nisha J D'Silva Laura S Rozek Maureen A Sartor Source Type: research
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Clinical Lung Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research
MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma
This study aimed to investigate the function of miR-5189-3p in laryngeal squamous cell carcinoma (LSCC) and explore its underlying mechanisms. qRT-PCR was designed to determine the expression levels of miR-5189-3p and eukaryotic translation initiation factor 5A2 (EIF5A2), while CCK-8 assay was performed to measure the effects of miR-5189-3p on cell proliferation. Transwell assay was performed to evaluate cell invasion as well as migration, and wound healing assay was applied to demonstrate cell migratory ability. Target gene prediction and luciferase reporter assay were developed to screen the possible target gene of miR-5...
Source: Biochemical Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Dan Lou Qiaojing Jia Haizhong Zhang Jingmiao Wang Lisha Liu Zhichang Liu Xiaofang Jia Jianxing Wang Chunguang Shan Source Type: research
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation. 2022 Oct 31;18(10):884-887. doi: 10.6026/97320630018884. eCollection 2022.ABSTRACTOral Squamous Cell Carcinoma comprises nearly 90% of all Oral cancers. Recent studies on Oral Squamous Cell Carcinoma are done with a focus on identification of factors that affect the outcome of treatment, one of which is vitamin D levels. The aim of this study was to evaluate vitamin D3 levels in patients with Oral Squamous Cell Carcinoma and Normal Population with saliva as a biomarker. The study sample comprised of 40 subjects, of whom 20 were patients diagnosed with OSCC and 20 healthy subjects. The salivary samples obtai...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Sandra Sagar Pratibha Raman S Gheena R Abilasha Reshma Poothakulath Krishnan J Selvaraj Source Type: research
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
