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Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan
J Microbiol Immunol Infect. 2023 Jul 20:S1684-1182(23)00123-8. doi: 10.1016/j.jmii.2023.07.004. Online ahead of print.ABSTRACTTen years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.PMID:37517964 | DOI:10.1016/j.jmii.2023.07.004
Source: Journal of Microbiology, Immunology, and Infection - July 30, 2023 Category: Microbiology Authors: Mitsuyo Kawaguchiya Noriko Urushibara Meiji Soe Aung Nobuhide Ohashi Rika Takamatsu Sho Tsutida Masahiko Ito Nobumichi Kobayashi Source Type: research

Serotypes and antimicrobial resistance of < em > Streptococcus pneumoniae < /em > in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay
Conclusion. A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.PMID:37289483 | DOI:10.1099/jmm.0.001700
Source: Journal of Medical Microbiology - June 8, 2023 Category: Microbiology Authors: Mar ía Eugenia León Margarita Samudio An íbal Kawabata Minako Nagai Liliana Rojas Noem í Zárate Juan Irala Myrian Leguizam ón Gloria G ómez Juana Ortellado Raquel Blasco Rossana Franco Gustavo Chamorro Source Type: research

Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines
Trends Microbiol. 2023 Mar 18:S0966-842X(23)00059-8. doi: 10.1016/j.tim.2023.02.011. Online ahead of print.ABSTRACTNeisseria meningitidis is a human-adapted pathogen that causes meningitis and sepsis worldwide. N. meningitidis factor H-binding protein (fHbp) provides a mechanism for immune evasion by binding human complement factor H (CFH) to protect it from complement-mediated killing. Here, we discuss features of fHbp which enable it to engage human CFH (hCFH), and the regulation of fHbp expression. Studies of host susceptibility and bacterial genome-wide association studies (GWAS) highlight the importance of the interac...
Source: Trends in Microbiology - March 20, 2023 Category: Microbiology Authors: Wearn-Xin Yee Grace Barnes Hayley Lavender Christoph M Tang Source Type: research

Microbiological and clinical characteristics of Streptococcus pneumoniae serotype 3 infection and risk factors for severe outcome: A multicenter observational study
CONCLUSIONS: Serotype 3 infection showed a high mortality rate, especially in patients with older ages and comorbidities. Although the incidence rates decreased during the COVID-19 pandemic, serotype 3 remained as an important cause of infection after the implementation of PCV13. Developing a more effective vaccine against serotype 3 and monitoring the antimicrobial-resistant sequence types are necessary.PMID:36774315 | DOI:10.1016/j.jmii.2023.01.013
Source: Journal of Microbiology, Immunology, and Infection - February 11, 2023 Category: Microbiology Authors: Merve Arslan Aydin Rajendra Prasad Janapatla Chyi-Liang Chen Hsin-Chieh Li Lin-Hui Su Cheng-Hsun Chiu Source Type: research

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