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Specialty: Cancer & Oncology
Vaccination: Covid Vaccine
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Total 699 results found since Jan 2013.
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 < sup > + < /sup > T cell formation
Sci Immunol. 2023 Sep 29;8(87):eadf7579. doi: 10.1126/sciimmunol.adf7579. Epub 2023 Sep 22.ABSTRACTMitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highli...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fabien Franco Alessio Bevilacqua Ruey-Mei Wu Kung-Chi Kao Chun-Pu Lin Lor ène Rousseau Fu-Ti Peng Yu-Ming Chuang Jhan-Jie Peng Jaeoh Park Yingxi Xu Antonino Cassotta Yi-Ru Yu Daniel E Speiser Federica Sallusto Ping-Chih Ho Source Type: research
Randomized Open-Label Controlled Study of Cancer Vaccine OSE2101 Versus Chemotherapy in HLA-A2-positive Patients with Advanced Non-Small Cell Lung Cancer with Resistance to Immunotherapy: ATALANTE-1
CONCLUSION: In HLA-A2 positive patients with advanced NSCLC and secondary resistance to immunotherapy, OSE2101 increased survival with better safety compared to chemotherapy. Further evaluation in this population is warranted.PMID:37704166 | DOI:10.1016/j.annonc.2023.07.006
Source: Ann Oncol - September 13, 2023 Category: Cancer & Oncology Authors: B Besse E Felip R Garcia Campelo M Cobo C Mascaux A Madroszyk F Cappuzzo W Hilgers G Romano F Denis S Viteri D Debieuvre D Galetta E Baldini None M Razaq G Robinet M Maio A Delmonte B Roch P Masson W Schuette A Zer J Remon D Costantini B Vasseur R Dziadzi Source Type: research
Growing Deficit in New Cancer Diagnoses 2 Years Into the COVID-19 Pandemic: A National Multicenter Study
CONCLUSION: Disruptions in new diagnoses of four common cancers (prostate, lung, bladder, and colorectal) seen early in the COVID-19 pandemic have persisted for 2 years. Although reductions improved from the early pandemic, new reductions during the Delta and Omicron waves demonstrate the continued impact of the COVID-19 pandemic on cancer care.PMID:37695458 | DOI:10.1245/s10434-023-14217-5
Source: Ann Oncol - September 11, 2023 Category: Cancer & Oncology Authors: Brian R Englum Shalini Sahoo Minerva Mayorga-Carlin Hilary Hayssen Tariq Siddiqui Douglas J Turner John D Sorkin Brajesh K Lal Source Type: research
Patient Report on the Impact of Coronavirus Disease 2019 and Living With Lung Cancer
CONCLUSIONS: An integrative patient-reported view on the impact of COVID-19 is important for adequate preparation to ensure undisrupted treatment and allocation of resources.PMID:37663676 | PMC:PMC10472288 | DOI:10.1016/j.jtocrr.2023.100549
Source: Clinical Lung Cancer - September 4, 2023 Category: Cancer & Oncology Authors: Tendai M Chihuri Upal Basu Roy Amy Moore Anne-Marie Baird Tracey L Grant Bellinda L King-Kallimanis Source Type: research
A unique cytotoxic CD4 < sup > + < /sup > T cell-signature defines critical COVID-19
CONCLUSION: Highly activated and cytotoxic CD4+ T-cell responses may contribute to cell-mediated host tissue damage and progression of COVID-19. Induction of these potentially detrimental T-cell responses should be considered when developing and implementing effective COVID-19 control strategies.PMID:37645435 | PMC:PMC10461786 | DOI:10.1002/cti2.1463
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Sarah Baird Caroline L Ashley Felix Marsh-Wakefield Sibel Alca Thomas M Ashhurst Angela L Ferguson Hannah Lukeman Claudio Counoupas Jeffrey J Post Pamela Konecny Adam Bartlett Marianne Martinello Rowena A Bull Andrew Lloyd Alice Grey Owen Hutchings Umaima Source Type: research
Knowledge, attitudes, concern, behaviors, and barriers associated with the readiness to receive seasonal influenza vaccine among healthcare workers in oncology setting during the COVID-19 pandemic
This study examines the knowledge, attitudes, concerns, behaviors, and barriers related to seasonal influenza vaccination among healthcare workers (HCWs) in the oncology setting during the COVID-19 pandemic. The objective is to assess the readiness of HCWs to receive the influenza vaccine. A cross-sectional study was conducted at the King Hussein Cancer Center (KHCC) in Amman, Jordan. HCWs were surveyed using a self-administered web-based questionnaire between October 2021 and November 2021. Among 223 participants, the coverage rates for seasonal influenza vaccination ranged from 65% to 81% during the autumns of 2019 and 2...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Sawsan Mubarak Hadeel AlGhawrie Bayan Qaddumi Source Type: research
COVID-19 Vaccination Effectiveness in the General Population of an Italian Province: Two Years of Follow-Up
Vaccines (Basel). 2023 Aug 4;11(8):1325. doi: 10.3390/vaccines11081325.ABSTRACTWe carried out a cohort study on the overall population of the province of Pescara, Italy, to assess the real-world effectiveness of SARS-CoV-2 vaccination against infection, severe, or lethal COVID-19, two years after the start of the vaccination campaign. We included all the resident or domiciled subjects, and extracted the official demographic, vaccination, COVID-19, hospital and co-pay exemption datasets from 1 January 2021, up to 15 February 2023. Cox proportional hazards analyses were adjusted for gender, age, diabetes, hypertension, COPD,...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Annalisa Rosso Maria Elena Flacco Graziella Soldato Giuseppe Di Martino Cecilia Acuti Martellucci Roberto Carota Marco De Benedictis Graziano Di Marco Rossano Di Luzio Matteo Fiore Antonio Caponetti Lamberto Manzoli Source Type: research
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research
Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency
Nat Commun. 2023 Aug 18;14(1):5032. doi: 10.1038/s41467-023-40758-0.ABSTRACTT-cell immunity is central for control of COVID-19, particularly in patients incapable of mounting antibody responses. CoVac-1 is a peptide-based T-cell activator composed of SARS-CoV-2 epitopes with documented favorable safety profile and efficacy in terms of SARS-CoV-2-specific T-cell response. We here report a Phase I/II open-label trial (NCT04954469) in 54 patients with congenital or acquired B-cell deficiency receiving one subcutaneous CoVac-1 dose. Immunogenicity in terms of CoVac-1-induced T-cell responses and safety are the primary and seco...
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Jonas S Heitmann Claudia Tandler Maddalena Marconato Annika Nelde Timorshah Habibzada Susanne M Rittig Christian M Tegeler Yacine Maringer Simon U Jaeger Monika Denk Marion Richter Melek T Oezbek Karl-Heinz Wiesm üller Jens Bauer Jonas Rieth Marcel Wacke Source Type: research
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research
Understanding Concerns about COVID-19 and Vaccination: Perspectives from Kidney Transplant Recipients
Vaccines (Basel). 2023 Jun 22;11(7):1134. doi: 10.3390/vaccines11071134.ABSTRACTThe COVID-19 pandemic poses a significant risk for immunosuppressed groups such as transplant patients. The purpose of this study was to improve our understanding of the impact of the COVID-19 pandemic on kidney transplant recipients, including their views on COVID-19 vaccination. Semi-structured interviews were conducted from December 2021 to August 2022 with 38 kidney transplant recipients who had an appointment with their transplant care team within the previous 6 months. We used qualitative thematic analysis to characterize the perspectives...
Source: Cancer Control - July 29, 2023 Category: Cancer & Oncology Authors: Sarah R MacEwan Alice A Gaughan Graham N Dixon Ramona G Olvera Willi L Tarver Saurabh Rahurkar Laura J Rush Austin D Schenk Jack Stevens Ann Scheck McAlearney Source Type: research
Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine
Mol Ther Methods Clin Dev. 2023 Jun 27;30:194-207. doi: 10.1016/j.omtm.2023.06.009. eCollection 2023 Sep 14.ABSTRACTBecause of continual generation of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to design the next generation of vaccines to combat the threat posed by SARS-CoV-2 variants. We developed human adenovirus (HAd) vector-based vaccines (HAd-Spike/C5 and HAd-Spike) that express the whole Spike (S) protein of SARS-CoV-2 with or without autophagy-inducing peptide C5 (AIP-C5), respectively. Mice or golden Syrian hamsters immunized intranasally (i.n.) with HAd-Spike/C5 in...
Source: Clinical Lung Cancer - July 28, 2023 Category: Cancer & Oncology Authors: Ekramy E Sayedahmed Marcelo Valdemir Ara újo Taiana Tain á Silva-Pereira Shubhada K Chothe Ahmed Elkashif Marwa Alhashimi Wen-Chien Wang Andrea P Santos Meera Surendran Nair Abhinay Gontu Ruth Nissly Ant ônio Francisco de Souza Filho Mariana Silva Tava Source Type: research
Health Literacy and COVID-19 Vaccination among Cancer Patients in Northeastern Thailand: A Cross-Sectional Study
CONCLUSIONS: The strongest predictor of receiving COVID-19 vaccines was health literacy, which enhances healthcare provider awareness of communicable disease prevention and control for patients with cancer as well as counselling and educating to improve their health literacy. It could influent a higher rate of vaccine uptake among patients with cancer.PMID:37505769 | DOI:10.31557/APJCP.2023.24.7.2375
Source: Cancer Control - July 28, 2023 Category: Cancer & Oncology Authors: Phichet Dapha Surachai Phimha Nakarin Prasit Nopparat Senahad Source Type: research
