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Google ’s AI Lab, DeepMind, Offers ‘Gift to Humanity’ with Protein Structure Solution
Matt Higgins and his team of researchers at the University of Oxford had a problem. For years, they had been studying the parasite that spreads malaria, a disease that still kills hundreds of thousands of people every year. They had identified an important protein on the surface of the parasite as a focal point for a potential future vaccine. They knew its underlying chemical code. But the protein’s all-important 3D structure was eluding them. That shape was the key to developing the right vaccine to slide in and block the parasite from infecting human cells. [time-brightcove not-tgx=”true”] The team&rsqu...
Source: TIME: Science - July 28, 2022 Category: Science Authors: Billy Perrigo Tags: Uncategorized Artificial Intelligence biztech2030 Source Type: news

Lack of plasmodium surface-protein blocks mosquito infection
A previously unknown feature of the malaria parasite development has just been released by an international research team. Their study has shown that, contrary to what has been assumed so far, a Plasmodium surface-protein plays an essential role at a stage of its life cycle that occurs not in the body of the host, but in the guts of the Anopheles mosquito. The finding has consequences for the search for vaccines or drugs that could alleviate the suffering caused by malaria. By 2015, 214 million people were affected by the parasite, especially in Africa.
Source: ScienceDaily Headlines - November 9, 2016 Category: Science Source Type: news

Finding the Origin of Human Disease
We're still trying to eradicate diseases that have plagued humans for centuries. References to malaria, for instance, have been found in recorded history in 2700 BC China. Riaan Rifkin, a prehistoric archaeologist, together with geneticists at the University of Pretoria, South Africa gets down to the root of origins of human disease pathogens in sub-Saharan Africa, the cradle of mankind. He and his team are trying to pin down the origins of human disease and establish a sub-Saharan African disease baseline that precedes the exodus of Homo sapiens from Africa 65000 years ago and, perhaps, to also assist in the discovery of ...
Source: Science - The Huffington Post - May 18, 2016 Category: Science Source Type: news

World's First Malaria Vaccine Delayed as WHO Experts Urge Caution
The decision is likely to delay a possible broad roll-out of the shot for between three and five years -- Read more on ScientificAmerican.com
Source: Scientific American - Official RSS Feed - October 26, 2015 Category: Science Tags: Health Medicine Pharmaceuticals Public Health The Body Wellness Source Type: research

In Case You Missed It:
The first 3-D–-printed drug, a malaria vaccine approval and more! / Top news from around the world -- Read more on ScientificAmerican.com
Source: Scientific American - Official RSS Feed - September 20, 2015 Category: Science Tags: Advances The Sciences Source Type: research

In Case You Missed It--Top News from around the World
The first 3-D–-printed drug, a malaria vaccine approval and more! -- Read more on ScientificAmerican.com
Source: Scientific American - Official RSS Feed - September 20, 2015 Category: Science Tags: Advances The Sciences Source Type: research

New malaria vaccine candidates identified
Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children.
Source: ScienceDaily Headlines - July 30, 2014 Category: Science Source Type: news

TREM2 controls malaria liver stage infection Medical Sciences
Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for mechanisms underlying natural host resistance to infection and identified triggering receptor expressed on myeloid cells 2 (TREM2) and MHC class II molecules as determinants of...
Source: Proceedings of the National Academy of Sciences - November 26, 2013 Category: Science Authors: Goncalves, L. A., Rodrigues–Duarte, L., Rodo, J., Vieira de Moraes, L., Marques, I., Penha–Goncalves, C. Tags: Biological Sciences Source Type: research

Zapped Malaria Parasite Raises Vaccine Hopes
A malaria vaccine has become the first to provide 100% protection against the disease, confounding critics and far surpassing any other experimental malaria vaccine tested. It will now be tested further in clinical trials in Africa. [More]
Source: Scientific American - Official RSS Feed - August 8, 2013 Category: Science Tags: Health,Infectious Diseases,Biotechnology,Biotechnology,Health,Society & Policy Source Type: research