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Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research

Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates
Vaccine. 2023 Aug 8:S0264-410X(23)00913-1. doi: 10.1016/j.vaccine.2023.07.067. Online ahead of print.ABSTRACTDevelopment of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding C...
Source: Vaccine - August 10, 2023 Category: Allergy & Immunology Authors: Melanie J Shears Felicia N Watson Brad C Stone Irene Cruz Talavera Chaitra Parthiban Jokichi Matsubara Natasha Kc B Kim Lee Sim Stephen L Hoffman Sean C Murphy Source Type: research

The immunity modulation of transforming growth factor- β in malaria and other pathological process
Int Immunopharmacol. 2023 Jul 17;122:110658. doi: 10.1016/j.intimp.2023.110658. Online ahead of print.ABSTRACTThe main causative agent of malaria in humans is Plasmodium falciparum, which is spread through biting Anopheles mosquitoes. Immunoregulation in the host involving the pleiotropic cytokine transforming growth factor-β (TGF-β) has a vital role in controlling the immune response to P. falciparum infection. Based on a search of the published literature, this study investigated the correlation between malaria and immune cells, specifically the role of TGF-β in the immune response. The studies analyzed showed that, w...
Source: International Immunopharmacology - July 19, 2023 Category: Allergy & Immunology Authors: Shuang Wu Qing Nie Shuang Tan Guoyan Liao Yinyi Lv Caohua Lv Guang Chen Shuangchun Liu Source Type: research

Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review
ConclusionSeveral challenges need to be addressed to ensure the success of vaccination programs. From the acceptability perspective, issues such as inadequate community engagement, concerns about side effects, and issues with the delivery and quality of healthcare services can affect the acceptance of the vaccine. From the feasibility standpoint, factors such as lack of transportation or long distances to healthcare facilities and the perception of completion of the vaccination calendar can affect the feasibility of the vaccine. Lastly, the availability of the vaccine is also a major concern as it may not be readily availa...
Source: Immunity, Inflammation and Disease - June 14, 2023 Category: Allergy & Immunology Authors: Hassan Mumtaz, Abdullah Nadeem, Wajeeha Bilal, Farrukh Ansar, Saira Saleem, Qaisar Ali Khan, Tamara Tango, Christopher Farkouh, Naod F. Belay, Ravina Verma, Matthew Farkouh, Muhammad Saqib Tags: REVIEW ARTICLE Source Type: research

Clinical evaluation of commercial SARS-CoV-2 serological assays in a malaria endemic setting
J Immunol Methods. 2023 May 11:113488. doi: 10.1016/j.jim.2023.113488. Online ahead of print.ABSTRACTThe levels of immune response to SARS-CoV-2 infection or vaccination are poorly understood in African populations and is complicated by cross-reactivity to endemic pathogens as well as differences in host responsiveness. To begin to determine the best approach to minimize false positive antibody levels to SARS-CoV-2 in an African population, we evaluated three commercial assays, namely Bio-Rad Platelia SARS-CoV-2 Total Antibody (Platelia), Quanterix Simoa Semi-Quantitative SARS-CoV-2 IgG Antibody Test (anti-Spike), and the ...
Source: Journal of Immunological Methods - May 13, 2023 Category: Allergy & Immunology Authors: Djeneba Dabitao Kathryn Shaw-Saliba Drissa S Konate Helene C Highbarger Perrine Lallemand Ibrahim Sanogo Tauseef Rehman Mamadou Wague Nadie Coulibaly Bourahima Kone Bocar Baya Seidina A S Diakite Seydou Samake Esther Akpa Moctar Tounkara Sylvain Laverdure Source Type: research

Extending the range of Plasmodium falciparum transmission blocking antibodies
Vaccine. 2023 Apr 24:S0264-410X(23)00453-X. doi: 10.1016/j.vaccine.2023.04.042. Online ahead of print.ABSTRACTRecent work demonstrating that asymptomatic carriers of P. falciparum parasites make up a large part of the infectious reservoir highlights the need for an effective malaria vaccine. Given the historical challenges of vaccine development, multiple parasite stages have been targeted, including the sexual stages required for transmission. Using flow cytometry to efficiently screen for P. falciparum gamete/zygote surface reactivity, we identified 82 antibodies that bound live P. falciparum gametes/zygotes. Ten antibod...
Source: Vaccine - April 26, 2023 Category: Allergy & Immunology Authors: Lacy M Simons Patricia Ferrer Nita Gombakomba Knashka Underwood Raul Herrera David L Narum Gaspar Canepa Festus Acquah Linda Amoah Patrick E Duffy Carolina Barillas-Mury Carole Long Shwu-Maan Lee Emily Locke Kazutoyo Miura Kim C Williamson Source Type: research

Modelling the relative cost-effectiveness of the RTS,S/AS01 malaria vaccine compared to investment in vector control or chemoprophylaxis
CONCLUSIONS: Use of RTS,S results in reductions in malaria cases and deaths even when layered upon existing interventions. When comparing relative cost-effectiveness, scale up of ITNs, introduction of SMC, and switching to new technology nets should be prioritized in eligible settings.PMID:37080831 | DOI:10.1016/j.vaccine.2023.04.011
Source: Vaccine - April 18, 2023 Category: Allergy & Immunology Authors: Hillary M Topazian Nora Schmit Ines Gerard-Ursin Giovanni D Charles Hayley Thompson Azra C Ghani Peter Winskill Source Type: research

Systematic Review of Safety of RTS,S with AS01 and AS02 Adjuvant Systems Using Data from Randomized Controlled Trials in Infants, Children, and Adults
CONCLUSION: Most of the adverse events observed from RTS,S/AS01 and RTS,S/AS02 malaria vaccines were reported in the control group and shared by other vaccines. Hence, the authors concluded that both RTS,S/AS01 and RTS,S/AS02 malaria vaccines are safe.PMID:36941908 | PMC:PMC10024506 | DOI:10.2147/CPAA.S400155
Source: Clinical Pharmacology: Advances and Applications - March 21, 2023 Category: Allergy & Immunology Authors: Wubetu Yihunie Bekalu Kebede Bantayehu Addis Tegegne Melese Getachew Dehnnet Abebe Yibeltal Aschale Habtamu Belew Bereket Bahiru Source Type: research

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