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Specialty: Infectious Diseases
Vaccination: Veterinary Vaccinations
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Total 648 results found since Jan 2013.
Burdening Perspectives and Treatment Modalities of Monkeypox: A Central Dogma
Infect Disord Drug Targets. 2023 Aug 25. doi: 10.2174/1871526523666230825164222. Online ahead of print.ABSTRACTThe monkeypox virus (MPXV), belonging to the genus Orthopoxvirus, is responsible for causing the zoonotic illness known as Monkeypox. The virus was initially identified during an outbreak at a Danish Zoo in 1958 and has since been found to infect various mammal species worldwide. While African squirrels and other rodents are believed to be the primary hosts, determining the natural host has proven challenging. While MPXV can be studied using different animal models in laboratory settings, understanding its natural...
Source: Infectious Disorders Drug Targets - September 12, 2023 Category: Infectious Diseases Authors: Shivang Dhoundiyal Md Aftab Alam Awaneet Kaur Sandesh Varshney Source Type: research
Boosting of vaginal HSV-2-specific B and T cell responses by intravaginal therapeutic immunization results in diminished recurrent HSV-2 disease
In this study, a therapeutic vaccine given intravaginally resulted in significantly better protection against HSV-2 disease than immunization with the same vaccine by a conventional route. Immunization by the intravaginal route resulted in greater stimulation of vaginal-resident, virus-specific cells that produced antibody and produced immune molecules to rapidly clear virus.PMID:37655939 | DOI:10.1128/jvi.00669-23
Source: Herpes - September 1, 2023 Category: Infectious Diseases Authors: Nigel Bourne Celeste A Keith Aaron L Miller Richard B Pyles Gary Cohen Gregg N Milligan Source Type: research
Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Kenneth Lundstrom Source Type: research
ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Viruses. 2023 Jul 18;15(7):1570. doi: 10.3390/v15071570.ABSTRACTHerpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, vir...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Maria Korom Hong Wang Kaelin M Bernier Brian J Geiss Lynda A Morrison Source Type: research
The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice
In this study, we evaluated an immunotherapy protocol in a murine model by combining recombinant (r)LiHyp1 (a hypothetical amastigote-specific Leishmania protein protective against Leishmania infantum infection), with monophosphoryl-lipid A (MPLA) as adjuvant and amphotericin B (AmpB) as reference antileishmanial drug. We used this protocol to treat L. infantum infected-BALB/c mice, and parasitological, immunological and toxicological evaluations were performed at 1 and 30 days after treatment. Results showed that mice treated with rLiHyp1/MPLA/AmpB presented the lowest parasite burden in all organs evaluated, when both a ...
Source: Acta Tropica - July 15, 2023 Category: Infectious Diseases Authors: Daniela P Lage V ívian T Martins Danniele L Vale Camila S Freitas Breno L Pimenta Gabriel J L Moreira Fernanda F Ramos Isabela A G Pereira Raquel S Bandeira Marcelo M de Jesus Fernanda Ludolf Grasiele S V Tavares Miguel A Ch ávez-Fumagalli Bruno M Roatt Source Type: research
The Oncolytic herpes simplex virus type-1 (HSV-1) vaccine strain VC2 causes intratumor infiltration of functionally active T cells and inhibition of tumor metastasis and pro-tumor genes VEGF and PDL1 expression in the 4T1/Balb/c mouse model of stage four breast cancer
Conclusion: These results show that VC2 therapy can improve anti-tumor response associated with a better control of tumor metastasis. improve T cell responses and reduce pro-tumor biomarker gene transcription. VC2 holds promise for further development as an oncolytic and immunotherapeutic approach to treat breast and other cancers.PMID:37388243 | PMC:PMC10303929 | DOI:10.3389/fmolb.2023.1199068
Source: Herpes - June 30, 2023 Category: Infectious Diseases Authors: Rafiq Nabi Farhana Musarrat Jose Cesar Menk P Lima Ingeborg M Langohr Vladimir N Chouljenko Konstantin G Kousoulas Source Type: research
Challenges in the treatment and prevention of Monkeypox infection; a comprehensive review
Acta Trop. 2023 Jun 3:106960. doi: 10.1016/j.actatropica.2023.106960. Online ahead of print.ABSTRACTHuman monkeypox (HMPX) is a zoonotic disease, literally meaning that it can be passed on from animals (non-primate) to human (primate). All the reported and recorded cases have been traced back either to international travel or import of African animals. In the Unites states, sporadic monkeypox cases have been reported in specific over the past 50 years, starting its first identification in the Democratic Republic of the Congo (D.R.C.) in 1970. Due to its extreme versatility, this disease poses threat as a serious public hea...
Source: Acta Tropica - June 5, 2023 Category: Infectious Diseases Authors: Jennifer Nyame Saranya Punniyakotti Kanav Khera Rashmi Saxena Pal Nithya Varadarajan Prachi Sharma Source Type: research
