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Specialty: Virology
Vaccination: Hepatitis Vaccine
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Total 63 results found since Jan 2013.
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies
Antiviral Res. 2023 Jul 12:105670. doi: 10.1016/j.antiviral.2023.105670. Online ahead of print.ABSTRACTThe hepatitis E virus (HEV) is a major cause of hepatitis, with an estimated 3.3 million symptomatic cases annually. There is no HEV-specific treatment besides the off-label use of ribavirin and a vaccine is only available in China and Pakistan. To aid the development of therapeutic and preventive strategies, there is a need for convenient HEV infection models in small laboratory animals. To this end, we make use of the rat hepatitis E virus. Human infections with this virus have been reported in recent years, making it a...
Source: Antiviral Research - July 14, 2023 Category: Virology Authors: Xin Zhang Niels Cremers Stijn Hendrickx Yannick Debing Tania Roskams Lotte Coelmont Johan Neyts Suzanne J F Kaptein Source Type: research
Knob domain of Fiber 2 protein provides full protection against fowl adenovirus serotype 4
Virus Res. 2023 Apr 9:199113. doi: 10.1016/j.virusres.2023.199113. Online ahead of print.ABSTRACTHighly pathogenic fowl adenovirus serotype 4 (FAdV-4) is an acute infectious disease with severe economic impact, causing chicken hepatitis hydropericardium syndrome (HHS) and high mortality. In the present study, we evaluated the immunogenicity of the recombinant Fiber2-knob protein (F2-Knob) as an FAdV-4 candidate subunit vaccine in 14-day-old SPF chickens. The knob domain is the functional region of the viral surface protein Fiber2. The protein was expressed in Escherichia coli and was administered a single immunization with...
Source: Virus Research - April 11, 2023 Category: Virology Authors: Yapeng Song Zhenchao Zhao Lin Liu Yifei Li Wenming Gao Xiaonan Song Xinsheng Li Source Type: research
TWiV 998: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics...
Source: This Week in Virology - MP3 Edition - April 8, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 995: Viral origin stories
TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid. Click arrow to play Download TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • More evidence for SARS-CoV-2 s...
Source: This Week in Virology - MP3 Edition - March 26, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Human adenovirus type 7 virus-like particle vaccine induces Dendritic cell maturation through the TLR4/NF- κB pathway and is highly immunogenic
In this study, we designed a virus-like particle vaccine expressing the epitopes of hexon and penton of adenovirus type 7 with hepatitis B core protein (HBc) as the vector to induce high-level humoral and cellular immune responses. To evaluate the effectiveness of the vaccine, we first detected the expression of molecular markers on the surface of antigen presenting cells and the secretion of proinflammatory cytokines in vitro. We then measured the levels of neutralizing antibodies and T cell activation in vivo. The results showed that the HAdv-7 virus-like particles (VLPs) recombinant subunit vaccine could activate the in...
Source: Antiviral Research - February 22, 2023 Category: Virology Authors: Yiquan Li Zhiru Xiu Shanzhi Li Yilong Zhu Yaru Li Renshuang Zhao Yue Li Xia Yang Chenchen Ge Nan Li Ningyi Jin Chao Shang Xiao Li Jicheng Han Source Type: research
Therapies against chronic hepatitis B infections: The times they are a-changin', but the changing is slow!
Antiviral Res. 2023 Jan 2:105515. doi: 10.1016/j.antiviral.2022.105515. Online ahead of print.ABSTRACTAs a tribute to Dr Mike Bray, the following review of literature will concepts, but will also contain my personal views, and in this respect could be more considered as a bioassay. Even though a cost-effective and excellent prophylactic vaccine exists since many years to protect against hepatitis B virus (HBV) infection, academic-researcher/drug-developers/stakeholders are still busy with the R&D of novel therapies that could eventually have an impact on its worldwide incidence. The Taiwanese experience have univocally...
Source: Antiviral Research - January 5, 2023 Category: Virology Authors: David Durantel Source Type: research
