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Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic
Biomed Pharmacother. 2023 Aug 3;165:115254. doi: 10.1016/j.biopha.2023.115254. Online ahead of print.ABSTRACTDespite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack of clear guidelines on the use of methotrexate during vaccination. Significant progress was made during the COVID-19 pandemic due to the dynamic development of research on vaccines, including patients with autoimmune inf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 5, 2023 Category: Drugs & Pharmacology Authors: Jakub Wro ński Marzena Ciechomska Ewa Kuca-Warnawin Source Type: research

Biomaterial-based delivery platforms for transdermal immunotherapy
Biomed Pharmacother. 2023 Jun 27;165:115048. doi: 10.1016/j.biopha.2023.115048. Online ahead of print.ABSTRACTNowadays, immunotherapy is one of the most essential treatments for various diseases and a broad spectrum of disorders are assumed to be treated by altering the function of the immune system. For this reason, immunotherapy has attracted a great deal of attention and numerous studies on different approaches for immunotherapies have been investigated, using multiple biomaterials and carriers, from nanoparticles (NPs) to microneedles (MNs). In this review, the immunotherapy strategies, biomaterials, devices, and disea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 29, 2023 Category: Drugs & Pharmacology Authors: Mohammad Dahri Nima Beheshtizadeh Nasrin Seyedpour Amin Nakhostin-Ansari Faezeh Aghajani Simin Seyedpour Moein Masjedi Fatemeh Farjadian Reza Maleki Khosro Adibkia Source Type: research

The impacts of the COVID-19 pandemic on patients with viral hepatitis B infection: follow-up, compliance with antiviral treatment, and vaccine preferences
CONCLUSIONS: It was reported that elimination programs and interventions for HBV infection decreased or stopped because of the COVID-19 pandemic. In the present study, no newly diagnosed case of HBV infection was detected. Most of the patients had their follow-up visits disrupted. There were no patients who could not receive antiviral treatment, the vaccination rate of the patients was high, and the vaccines were well tolerated.PMID:37318505 | DOI:10.26355/eurrev_202306_32650
Source: Pharmacological Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: B Ozdemir A Altunsoy E Akinci R Guner Source Type: research

Hepatitis A seroprevalence and demographic risk factors in the susceptible population: a cross-sectional study
CONCLUSIONS: Socioeconomic development and immunization programs have altered HAV seroprevalence patterns. Planning catch-up vaccinations, especially in adolescents and young adults (born in 1994-2011) with low seropositivity and ensuring the continuity of hygiene and sanitation practices are important to protect the susceptible population.PMID:37318467 | DOI:10.26355/eurrev_202306_32610
Source: Pharmacological Reviews - June 15, 2023 Category: Drugs & Pharmacology Authors: E F Karasahin O Karasahin Source Type: research

Is the use of Tenofovir Dipivoxil fumarate effective and safe in preventing vertical transmission in pregnant women with chronic HBV with high viral load?
CONCLUSIONS: It has been observed that the use of TDF, which has a strong efficacy and high barrier, in the second and/or third trimester of pregnancy reduces transmission rates without causing side effects in both the mother and the newborn, thereby preventing vertical transmission of viral hepatitis B from the mother to child.PMID:36930508 | DOI:10.26355/eurrev_202303_31580
Source: Pharmacological Reviews - March 17, 2023 Category: Drugs & Pharmacology Authors: H Aladag M Aladag Source Type: research

Dissolving Microneedle Arrays as a Hepatitis B Vaccine Delivery System Adjuvanted by APC-Targeted Poly (Lactic-co-Glycolic Acid) (PLGA) Nanoparticles
This study verifies the feasibility of soluble composited microneedles administration in hepatitis B immunization, and provides new ideas for the development and application of non-injectable vaccine delivery systems.PMID:36697935 | DOI:10.1208/s12249-022-02473-9
Source: AAPS PharmSciTech - January 25, 2023 Category: Drugs & Pharmacology Authors: Xiaoling Zheng Jiahuan Zhu Caihong Zheng Zeng Tan Zhonghua Ji Jin Tao Yunchun Zhao Zhuwa Ji Ying Hu Source Type: research

Seroconversion following Heplisav-B, hepatitis B vaccine (recombinant), adjuvanted, in patients with end-stage renal disease at an urban safety net hospital
CONCLUSION: Patients with ESRD who received three 20-μg doses of recombinant HBV vaccine had a seroconversion rate of 83%, representing a similar seroconversion rate and fewer doses of vaccine as compared to the standard HBV vaccine regimen for patients with ESRD.PMID:36681904 | DOI:10.1093/ajhp/zxad022
Source: American Journal of Health-System Pharmacy : AJHP - January 22, 2023 Category: Drugs & Pharmacology Authors: Connor Walsh Kathryn McDaniel Lindsey Lindsey Sarah Johnson Ted Walton Source Type: research

Aquasomes: Advanced vesicular-based nanocarrier systems
CONCLUSION: In the near future, aquasomes based nano-drug delivery systems can be a fascinating field for research in nanotechnology.PMID:35909274 | DOI:10.2174/1381612828666220728112741
Source: Current Pharmaceutical Design - August 1, 2022 Category: Drugs & Pharmacology Authors: Samruddhi Kulkarni Bala Prabhakar Pravin Shende Source Type: research

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