Filtered By:
Specialty: Drugs & Pharmacology
Therapy: Stem Cell Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1884 results found since Jan 2013.
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells
In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.PMID:37729956 | DOI:10.1016/j.ejps.2023.106586
Source: European Journal of Pharmaceutical Sciences - September 20, 2023 Category: Drugs & Pharmacology Authors: Queenie Fernandes Lubna Therachiyil Abdul Q Khan Takwa Bedhiafi Hesham M Korashy Ajaz A Bhat Shahab Uddin Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
Phenylethanoid glycosides derived from Cistanche deserticola promote neurological functions and the proliferation of neural stem cells for improving ischemic stroke
This study aims to investigate whether PhGs treatment improves the stroke and its potential mechanisms. Adult male C57BL/6 J mice were administrated PhGs once daily for 7 days after MCAO surgery. The neurological score, and catwalk were evaluated on Day 1, 3 and 7 after ischemic stroke. Furthermore, triphenyl-2,3,5-tetrazoliumchloride (TTC) and hematoxylin-eosin (H&E) staining were used for evaluating the infarct volume and neuronal restoration. The effects of PhGs on NSCs proliferation were investigated in vitro and in vivo. Western blot was used to detect the proteins of Wnt/β-catenin signaling pathway. This study f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Jingjing Liu Yanyan Wang Qinyuan Li Tao Liu Xu Liu Han Zhang Zhifei Fu Yifan Dai Haiyuan Yang Yu Wang Ying Wang Source Type: research
Current progress in engineered and nano-engineered mesenchymal stem cells for cancer: From mechanisms to therapy
Biomed Pharmacother. 2023 Sep 14;167:115505. doi: 10.1016/j.biopha.2023.115505. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs), as self-renewing multipotent stromal cells, have been considered promising agents for cancer treatment. A large number of studies have demonstrated the valuable properties of MSC-based treatment, such as low immunogenicity and intrinsic tumor-trophic migratory properties. To enhance the potency of MSCs for therapeutic purposes, equipping MSCs with targeted delivery functions using genetic engineering is highly beneficial. Genetically engineered MSCs can express tumor suppressor agents...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Forough Shams Bahareh Pourjabbar Nader Hashemi Navid Farahmandian Ali Golchin Ghader Nuoroozi Azam Rahimpour Source Type: research
Therapeutic potential of mesenchymal stem cell-derived exosomal miR-296-5p and miR-337-3p in age-related erectile dysfunction via regulating PTEN/PI3K/AKT pathway
Biomed Pharmacother. 2023 Sep 7;167:115449. doi: 10.1016/j.biopha.2023.115449. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are viewed as an increasingly promising treatment for age-related erectile dysfunction (AED). Owing to the limitations of injecting living cells, the injection of exosomes appears to be a more plausible option. However, whether MSC-derived exosomes (MSC-Exos) improve AED and their potential mechanism remains unknown. MSC-Exos were prepared and injected intracavernously into aged rats to determine their effects on AED. Masson's trichrome staining was used to ascertain the changes in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2023 Category: Drugs & Pharmacology Authors: Kefan Li Ruiyu Li Zongyong Zhao Chen Feng Shuai Liu Qiang Fu Source Type: research
Application of 3D- printed hydrogels in wound healing and regenerative medicine
Biomed Pharmacother. 2023 Sep 6;167:115416. doi: 10.1016/j.biopha.2023.115416. Online ahead of print.ABSTRACTHydrogels are three-dimensional polymer networks with hydrophilic properties. The modifiable properties of hydrogels and the structure resembling living tissue allow their versatile application. Therefore, increasing attention is focused on the use of hydrogels as bioinks for three-dimensional (3D) printing in tissue engineering. Bioprinting involves the fabrication of complex structures from several types of materials, cells, and bioactive compounds. Stem cells (SC), such as mesenchymal stromal cells (MSCs) are fre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 8, 2023 Category: Drugs & Pharmacology Authors: Milena Deptu ła Ma łgorzata Zawrzykraj Justyna Sawicka Adrianna Banach-Kope ć Robert Tylingo Micha ł Pikuła Source Type: research
Infectious complications among patients receiving ibrutinib for the treatment of hematological malignancies
CONCLUSION: Serious infection and IFI rates are high but similar to those previously described. Risk factors for serious infection included allo-HSCT and corticosteroid use. Targeted antimicrobial prophylaxis should be evaluated in prospective studies in patients on ibrutinib to reduce serious infections and IFI.PMID:37675967 | DOI:10.1093/ajhp/zxad210
Source: American Journal of Health-System Pharmacy : AJHP - September 7, 2023 Category: Drugs & Pharmacology Authors: Kenneth Tham Stacy Prelewicz Sara deHoll Deborah M Stephens Carlos A Gomez Source Type: research
New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: a review
Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7653-7664. doi: 10.26355/eurrev_202308_33419.ABSTRACTBone regeneration following surgery, trauma, or any other condition is an autologous process that can fail, necessitating the requirement of novel procedures and materials. Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in spine surgery, orthopedics, and dentistry are facing many challenges and posing clinical concerns. A PubMed, MEDLINE, and Scopus review was carried out to identify all studies dealing with bone regenerative approaches in dent...
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: N Montemurro E Pierozzi A M Inchingolo B Pahwa A De Carlo A Palermo R Scarola G Dipalma M Corsalini A D Inchingolo F Inchingolo B Rapone Source Type: research
The clinical outcomes of intra-articular injection of human umbilical cord blood-derived mesenchymal stem cells vs. bone marrow aspirate concentrate in cartilage regeneration: a systematic review
CONCLUSIONS: This systematic review presents evidence that compared with BMAC injection, intra-articular hUCB-MSCs can induce significantly better tissue repair at 1 year after surgery, as assessed by the ICRS grade. Although there is only short-term follow-up evidence and a lack of histochemical evidence, our systematic review supports the recommendation to use hUCB-MSCs as the source of pluripotent stem cells for treating ICRS III cartilage lesions.PMID:37667930 | DOI:10.26355/eurrev_202308_33405
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: P-F Wang J Xing Source Type: research
New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: a review
Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7653-7664. doi: 10.26355/eurrev_202308_33419.ABSTRACTBone regeneration following surgery, trauma, or any other condition is an autologous process that can fail, necessitating the requirement of novel procedures and materials. Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in spine surgery, orthopedics, and dentistry are facing many challenges and posing clinical concerns. A PubMed, MEDLINE, and Scopus review was carried out to identify all studies dealing with bone regenerative approaches in dent...
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: N Montemurro E Pierozzi A M Inchingolo B Pahwa A De Carlo A Palermo R Scarola G Dipalma M Corsalini A D Inchingolo F Inchingolo B Rapone Source Type: research
The clinical outcomes of intra-articular injection of human umbilical cord blood-derived mesenchymal stem cells vs. bone marrow aspirate concentrate in cartilage regeneration: a systematic review
CONCLUSIONS: This systematic review presents evidence that compared with BMAC injection, intra-articular hUCB-MSCs can induce significantly better tissue repair at 1 year after surgery, as assessed by the ICRS grade. Although there is only short-term follow-up evidence and a lack of histochemical evidence, our systematic review supports the recommendation to use hUCB-MSCs as the source of pluripotent stem cells for treating ICRS III cartilage lesions.PMID:37667930 | DOI:10.26355/eurrev_202308_33405
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: P-F Wang J Xing Source Type: research
