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Specialty: Allergy & Immunology
Procedure: Liver Transplant
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Total 234 results found since Jan 2013.
Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges
J Autoimmun. 2023 Sep 8:103109. doi: 10.1016/j.jaut.2023.103109. Online ahead of print.ABSTRACTAutoimmune diseases (AIDs) are a series of immune-mediated lethal diseases featured by over-activated immune cells attacking healthy self-tissues and organs due to the loss of immune tolerance, which always causes severe irreversible systematical organ damage and threatens human health heavily. To date, there are still no definitive cures for the treatment of AIDs due to their pathogenesis has not been clearly understood. Besides, the current clinical treatments of AIDs majorly rely on glucocorticoids and immune suppressors, whic...
Source: Journal of Autoimmunity - September 10, 2023 Category: Allergy & Immunology Authors: Xiaomin Liu Mei Liu Ming Zhao Ping Li Changxing Gao Xinyu Fan Guangyan Cai Qianjin Lu Xiangmei Chen Source Type: research
Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase
This study provides a novel and effective potential drug with few side effects for easing liver IRI.PMID:37690240 | DOI:10.1016/j.intimp.2023.110809
Source: International Immunopharmacology - September 10, 2023 Category: Allergy & Immunology Authors: Jiansen Lu Wen Hou Shuang Yang Decheng Chen Fei Wang Lei Liu Zhongyang Shen Source Type: research
Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4 < sup > + < /sup > T cells after liver transplantation in rat
In conclusion, the autophagy inducer RAPA improved the mCAP-induced ferroptosis in CD4+ T cells. Our results support the concept of ferroptosis as an autophagy-dependent cell death and suggest that the combination of ferroptosis inducers and autophagy inducers is a new research direction for improving immunosuppressive regimens after liver transplantation.PMID:37625370 | DOI:10.1016/j.intimp.2023.110810
Source: International Immunopharmacology - August 25, 2023 Category: Allergy & Immunology Authors: Hao Wang Ruining Yang Zhenglu Wang Lei Cao Dejun Kong Qian Sun Sei Yoshida Jiashu Ren Tao Chen Jinliang Duan Jianing Lu Zhongyang Shen Hong Zheng Source Type: research
CSF-1R+ Macrophages Control the Gut Microbiome-enhanced Liver Invariant NKT Function through IL-18
In this study, we found that altering the gut microbiome by oral vancomycin increases liver invariant NKT (iNKT) cell function. Enhanced iNKT cytokine production and activation marker expression were observed in vancomycin-treated mice following both Ag-specific and Ag-independent in vivo iNKT stimulations, with a more prominent effect in the liver than in the spleen. Fecal transplantation studies demonstrated that the iNKT functional regulation is mediated by altering the gut microbiome but uncoupled from the modulation of iNKT cell population size. Interestingly, when stimulated in vitro, iNKT cells from vancomycin-treat...
Source: Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Chi Ma Justin McCallen John C McVey Rajiv Trehan Kylynda Bauer Qianfei Zhang Benjamin Ruf Sophie Wang Chunwei Walter Lai Giorgio Trinchieri Jay A Berzofsky Firouzeh Korangy Tim F Greten Source Type: research
Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4 < sup > + < /sup > T cells after liver transplantation in rat
In conclusion, the autophagy inducer RAPA improved the mCAP-induced ferroptosis in CD4+ T cells. Our results support the concept of ferroptosis as an autophagy-dependent cell death and suggest that the combination of ferroptosis inducers and autophagy inducers is a new research direction for improving immunosuppressive regimens after liver transplantation.PMID:37625370 | DOI:10.1016/j.intimp.2023.110810
Source: International Immunopharmacology - August 25, 2023 Category: Allergy & Immunology Authors: Hao Wang Ruining Yang Zhenglu Wang Lei Cao Dejun Kong Qian Sun Sei Yoshida Jiashu Ren Tao Chen Jinliang Duan Jianing Lu Zhongyang Shen Hong Zheng Source Type: research
Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF- κB/SMAD-4 pathways
This study aimed to evaluate the protective effect of zafirlukast (ZFK) on IR-induced hepatic injury and investigate its relevant protective mechanism. Thirty-two male Wistar albino rats were randomly allocated to four groups: sham, IRI, ZFK, and ZFK + IR groups. ZFK was administered orally in a dose of 80 mg/kg/day for 10 consecutive days. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL) levels, and gamma glutamyl transferase (GGT) activity were estimated. Liver tissues were used to assess oxidative stress biomarkers including malondialdehyde (MDA), myeloperoxidase (MPO), nitri...
Source: International Immunopharmacology - July 7, 2023 Category: Allergy & Immunology Authors: Heba M Mahmoud Deiaa E Elsayed Abouzed Amira M Abo-Youssef Ramadan A M Hemeida Source Type: research
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis
Int Immunopharmacol. 2023 Jun 20;121:110505. doi: 10.1016/j.intimp.2023.110505. Online ahead of print.ABSTRACT5-lipoxygenase (encoded by ALOX5) plays an important role in immune regulation. Zileuton is currently the only approved ALOX5 inhibitor. However, the mechanisms of ALOX5 and Zileuton in progression of pancreatic cancer remain unclear. Therefore, we investigated the effects of Zileuton on tumor-associated macrophage M2 polarization and pancreatic cancer invasion and metastasis, both in vivo and in vitro. In bulk RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) analyses, we found a significant asso...
Source: International Immunopharmacology - June 22, 2023 Category: Allergy & Immunology Authors: Wei-Min Hu Si-Qing Liu Kong-Fan Zhu Wei Li Zhi-Jian Yang Qiang Yang Zhong-Chao Zhu Jian Chang Source Type: research
Withaferin-A alleviates acute graft versus host disease without compromising graft versus leukemia effect
In conclusion, our study demonstrates the utility of WA for the prevention and treatment of aGvHD, which should be further evaluated in a clinical setting.PMID:37311352 | DOI:10.1016/j.intimp.2023.110437
Source: International Immunopharmacology - June 13, 2023 Category: Allergy & Immunology Authors: Saurabh Kumar Gupta Dievya Gohil Deepshikha Dutta Girish Ch Panigrahi Puja Gupta Kajal Dalvi Twinkle Khanka Subhash Yadav Rajiv Kumar Kaushal Akanksha Chichra Sachin Punatar Anant Gokarn Sumeet Mirgh Nishant Jindal Lingaraj Nayak Prashant R Tembhare Syed Source Type: research
Luteolin attenuates acute liver allograft rejection in rats by inhibiting T cell proliferation and regulating T cell subsets
In this study, a rat liver transplantation model was constructed to investigate the effect of LUT on acute rejection of organ allografts. We found that LUT significantly protected the structure and function of liver grafts, prolonged recipient rat survival, ameliorated T cell infiltration, and downregulated proinflammatory cytokines. Moreover, LUT inhibited the proliferation of CD4+ T cells and Th cell differentiation but increased the proportion of Tregs, which is the key to its immunosuppressive effect. In vitro, LUT also significantly inhibited CD4+ T cell proliferation and Th1 differentiation. There may be important im...
Source: International Immunopharmacology - June 8, 2023 Category: Allergy & Immunology Authors: Hao Wang Chenxuan Li Zhiwei Xiong Ting Li Source Type: research
