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Specialty: Molecular Biology
Procedure: Transplants
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Total 1335 results found since Jan 2013.
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Myocardial perfusion scintigraphy in the assessment of cardiovascular risk in adult liver transplantation
CONCLUSIONS: MPS is a safe and reliable technique for cardiovascular assessment of patients who are candidates for liver transplantation, given the low rate of false negatives during follow-up.PMID:37726078 | DOI:10.1016/j.remnie.2023.09.001
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: C Guti érrez-Villamil C Zuluaga-Arbelaez G Hern ández N Hern ández-Hidalgo V Mar ín-Oyaga Source Type: research
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
CONCLUSIONS: Our study demonstrated that IX prevents obesity and enhances glucose metabolism by inhibiting dietary fat absorption. This mechanism is linked to suppressing pancreatic lipase activity and shifts in microbial composition, notably an increase in A. muciniphila. These highlight new treatment strategies for preventing metabolic syndrome by boosting the gut microbiota with food components.PMID:37709134 | DOI:10.1016/j.molmet.2023.101797
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yoshiyuki Watanabe Shiho Fujisaka Yoshitomo Morinaga Shiro Watanabe Allah Nawaz Hideki Hatta Tomonobu Kado Ayumi Nishimura Muhammad Bilal Muhammad Rahil Aslam Keiko Honda Yoshimi Nakagawa Samir Softic Kenichi Hirabayashi Takashi Nakagawa Yoshinori Nagai K Source Type: research
Macrophage colony-stimulating factor as a weapon against cytomegalovirus
EMBO Mol Med. 2023 Sep 12:e18319. doi: 10.15252/emmm.202318319. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection is one of the severe opportunistic infections faced by severely immunocompromised patients. High viral loads cause tissue-invasive disease and expose to death or various indirect effects. Substantial progress was made in monitoring active infection, and antiviral drugs were developed. However, dose-limiting toxicities and genotypic resistance limit therapeutic efficacy and vaccine development is hampered by the complex biology of the virus. In this issue of EMBO Molecular Medicine, Kandalla et al (2...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Eric Solary Source Type: research
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
Clinical usage of dental stem cells and their derived extracellular vesicles
Prog Mol Biol Transl Sci. 2023;199:297-326. doi: 10.1016/bs.pmbts.2023.03.005. Epub 2023 Jul 26.ABSTRACTStem cell-based therapies remain at the forefront of tissue engineering and regenerative medicine because stem cells are a unique cell source with enormous potential to treat incurable diseases and even extend lifespans. The search for the best stem cell candidates continues to evolve and in recent years, dental stem cells have received significant attention due to their easy accessibility, high plasticity, and multipotential properties. Dental stem cells have been the subject of extensive research in both animal models ...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Yinghong Zhou Tian Xu Cong Wang Pingping Han Sa šo Ivanovski Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
Prog Mol Biol Transl Sci. 2023;199:155-178. doi: 10.1016/bs.pmbts.2023.02.009. Epub 2023 Jul 26.ABSTRACTAs a metabolic organ, the liver plays a variety of roles, including detoxification. It has been difficult to obtain stable supplies of hepatocytes for transplantation and for accurate hepatotoxicity determination in drug discovery research. Human pluripotent stem cells, capable of unlimited self-renewal, may be a promising source of hepatocytes. In order to develop a stable supply of embryonic stem cell (ESC)-derived hepatocytes, we have purified human ESC-derived hepatic progenitor cells with exposure to cytocidal purom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Saeko Akiyama Noriaki Saku Shoko Miyata Kenta Ite Hidenori Nonaka Masashi Toyoda Akihide Kamiya Tohru Kiyono Tohru Kimura Mureo Kasahara Akihiro Umezawa Source Type: research
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
Clinical usage of dental stem cells and their derived extracellular vesicles
Prog Mol Biol Transl Sci. 2023;199:297-326. doi: 10.1016/bs.pmbts.2023.03.005. Epub 2023 Jul 26.ABSTRACTStem cell-based therapies remain at the forefront of tissue engineering and regenerative medicine because stem cells are a unique cell source with enormous potential to treat incurable diseases and even extend lifespans. The search for the best stem cell candidates continues to evolve and in recent years, dental stem cells have received significant attention due to their easy accessibility, high plasticity, and multipotential properties. Dental stem cells have been the subject of extensive research in both animal models ...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Yinghong Zhou Tian Xu Cong Wang Pingping Han Sa šo Ivanovski Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
Prog Mol Biol Transl Sci. 2023;199:155-178. doi: 10.1016/bs.pmbts.2023.02.009. Epub 2023 Jul 26.ABSTRACTAs a metabolic organ, the liver plays a variety of roles, including detoxification. It has been difficult to obtain stable supplies of hepatocytes for transplantation and for accurate hepatotoxicity determination in drug discovery research. Human pluripotent stem cells, capable of unlimited self-renewal, may be a promising source of hepatocytes. In order to develop a stable supply of embryonic stem cell (ESC)-derived hepatocytes, we have purified human ESC-derived hepatic progenitor cells with exposure to cytocidal purom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Saeko Akiyama Noriaki Saku Shoko Miyata Kenta Ite Hidenori Nonaka Masashi Toyoda Akihide Kamiya Tohru Kiyono Tohru Kimura Mureo Kasahara Akihiro Umezawa Source Type: research
The role of regulatory T cells in the pathogenesis of acute kidney injury
In this study, we found significant differences in the IME between AKI and Non-AKI, including differences in Tregs cells and activation levels of biologically significant signalling pathways. Tregs were associated with lower activity of signalling pathways such as inflammatory response, inflammatory molecule secretion, immune activation, glycolysis.PMID:37667551 | DOI:10.1111/jcmm.17771
Source: J Cell Mol Med - September 5, 2023 Category: Molecular Biology Authors: Xiaoyou Liu Jianmin Hu Guorong Liao Ding Liu Song Zhou Jie Zhang Jun Liao Zefeng Guo Yuzhu Li Siqiang Yang Shichao Li Hua Chen Ying Guo Min Li Lipei Fan Liuyang Li Ming Zhao Yongguang Liu Source Type: research
