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Breast Cancer in Geriatric Patients: Current Landscape and Future Prospects
Clin Interv Aging. 2022 Sep 28;17:1445-1460. doi: 10.2147/CIA.S365497. eCollection 2022.ABSTRACTBreast cancer is the most common cancer diagnosed among women worldwide and more than half are diagnosed above the age of 60 years. Life expectancy is increasing and the number of breast cancer cases diagnosed among older women are expected to increase. Undertreatment, mostly due to unjustifiable fears of advanced-age and associated comorbidities, is commonly practiced in this group of patients who are under-represented in clinical trials and their management is not properly addressed in clinical practice guidelines. With modern...
Source: Clinical Breast Cancer - October 6, 2022 Category: Cancer & Oncology Authors: Hikmat Abdel-Razeq Fawzi Abu Rous Fawzi Abuhijla Nayef Abdel-Razeq Sarah Edaily Source Type: research

Outcome analysis of primary breast cancer patients who declined adjuvant chemotherapy-results from the prospective multi-center BRENDA II study
CONCLUSION: The prospective BRENDA II study demonstrates benefit in RFS by guideline adherence in adjuvant breast cancer treatment, indicating prospectively the value of internationally validated guidelines in breast cancer care.PMID:35178667 | DOI:10.1007/s12282-021-01321-1
Source: Breast Cancer - February 18, 2022 Category: Cancer & Oncology Authors: Elena Leinert Lukas Schwentner Wolfgang Janni Achim W öckel Saskia-L Herbert Daniel Herr Thorsten K ühn Felix Flock Ricardo Felberbaum Rolf Kreienberg Visnja Fink Davut Dayan Kristina Ernst Susanne Singer BRENDA study group Source Type: research

Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus).
CONCLUSIONS: Primary endocrine therapy should only be offered to women with oestrogen receptor (ER)-positive tumours who are unfit for surgery, at increased risk of serious surgical or anaesthetic complications if subjected to surgery, or who refuse surgery. In a cohort of women with significant co-morbid disease and ER-positive tumours it is possible that primary endocrine therapy may be a superior option to surgery. Trials are needed to evaluate the clinical effectiveness of aromatase inhibitors as primary therapy for an infirm older population with ER-positive tumours. PMID: 24838672 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 16, 2014 Category: Journals (General) Authors: Morgan J, Wyld L, Collins KA, Reed MW Tags: Cochrane Database Syst Rev Source Type: research