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A closer look: ultrastructural evaluation of high-risk progression IgA nephropathy
Ultrastruct Pathol. 2023 Sep 12:1-9. doi: 10.1080/01913123.2023.2256836. Online ahead of print.ABSTRACTThis retrospective, cross-sectional study sought to examine the ultrastructural characteristics of glomerular lesions using Transmission Electron Microscopy (TEM) in IgA nephropathy (IgAN) and their relationship with the high risk of progression phenotype defined by KDIGO guideline as proteinuria ≥1 g/24 hours despite 3 months of optimized supportive care. We analyzed 81 IgAN patients (median age 41 years, 67% male, eGFR 43.8 mL/min, proteinuria 1.04 g/day); 42 (52%) of them had high risk of progression. There were no d...
Source: Ultrastructural Pathology - September 13, 2023 Category: Pathology Authors: George Terinte-Balcan Gabriel Stefan Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: The American Journal of Pathology - September 13, 2023 Category: Pathology Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: Am J Pathol - September 13, 2023 Category: Pathology Source Type: research
A closer look: ultrastructural evaluation of high-risk progression IgA nephropathy
Ultrastruct Pathol. 2023 Sep 12:1-9. doi: 10.1080/01913123.2023.2256836. Online ahead of print.ABSTRACTThis retrospective, cross-sectional study sought to examine the ultrastructural characteristics of glomerular lesions using Transmission Electron Microscopy (TEM) in IgA nephropathy (IgAN) and their relationship with the high risk of progression phenotype defined by KDIGO guideline as proteinuria ≥1 g/24 hours despite 3 months of optimized supportive care. We analyzed 81 IgAN patients (median age 41 years, 67% male, eGFR 43.8 mL/min, proteinuria 1.04 g/day); 42 (52%) of them had high risk of progression. There were no d...
Source: Ultrastructural Pathology - September 13, 2023 Category: Pathology Authors: George Terinte-Balcan Gabriel Stefan Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: The American Journal of Pathology - September 13, 2023 Category: Pathology Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: The American Journal of Pathology - September 13, 2023 Category: Pathology Source Type: research
A closer look: ultrastructural evaluation of high-risk progression IgA nephropathy
Ultrastruct Pathol. 2023 Sep 12:1-9. doi: 10.1080/01913123.2023.2256836. Online ahead of print.ABSTRACTThis retrospective, cross-sectional study sought to examine the ultrastructural characteristics of glomerular lesions using Transmission Electron Microscopy (TEM) in IgA nephropathy (IgAN) and their relationship with the high risk of progression phenotype defined by KDIGO guideline as proteinuria ≥1 g/24 hours despite 3 months of optimized supportive care. We analyzed 81 IgAN patients (median age 41 years, 67% male, eGFR 43.8 mL/min, proteinuria 1.04 g/day); 42 (52%) of them had high risk of progression. There were no d...
Source: Ultrastructural Pathology - September 13, 2023 Category: Pathology Authors: George Terinte-Balcan Gabriel Stefan Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: Am J Pathol - September 13, 2023 Category: Pathology Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
This Month in AJP
Am J Pathol. 2023 Sep 11:S0002-9440(23)00318-8. doi: 10.1016/j.ajpath.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37704096 | DOI:10.1016/j.ajpath.2023.09.001
Source: Am J Pathol - September 13, 2023 Category: Pathology Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
