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Therapy: Stem Cell Therapy
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Lipocalin 2 induces self-limited inhibition of osteoblast differentiation of mesenchymal stem cells
CONCLUSION: Lcn2 is essential for normal osteogenic differentiation of MSCs, but its overexpression and excessive secretion in aging induce self-limited inhibition of osteogenic differentiation of MSCs.PMID:37712270 | PMC:PMC10505573 | DOI:10.12122/j.issn.1673-4254.2023.08.10
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Chen S Li Y Zhang W Yang T Wang Source Type: research
Cis-regulatory arbitrators of regeneration
Cell Stem Cell. 2023 Sep 6:S1934-5909(23)00295-3. doi: 10.1016/j.stem.2023.08.012. Online ahead of print.ABSTRACTMammals favor healing with scaring over functional tissue regeneration.1 In this issue of Cell Stem Cell, Mack et al. use "super-healer" mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.2.PMID:37714155 | DOI:10.1016/j.stem.2023.08.012
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Piotr Konieczny Shruti Naik Source Type: research
Metformin inhibits self-renewal of colorectal cancer stem cells by inhibiting mitochondrial oxidative phosphorylation
CONCLUSION: Metformin reduces mitochondrial oxidative phosphorylation and ROS levels by inhibiting mitochondrial complex Ⅰ, thereby suppressing Wnt signaling pathway to reduce selfrenewal ability of colorectal CSCs.PMID:37712263 | PMC:PMC10505579 | DOI:10.12122/j.issn.1673-4254.2023.08.03
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: C Yan S Liu Q Song Y Hu Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Hypoxic Mesenchymal Stem Cells Promote Diabetic Wound Healing in Rats by Increasing VEGF Secretion
Biomed Environ Sci. 2023 Aug 20;36(8):756-759. doi: 10.3967/bes2023.100.NO ABSTRACTPMID:37711087 | DOI:10.3967/bes2023.100
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Su Jing Zhuang Xu Yan Sun Meng Luo Zhong Wang Xue Juan Zhang Zong Sheng Gao Jian Liu Xin Ran Liu Shi Ze Liu Xiao Peng Jia Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Hypoxic Mesenchymal Stem Cells Promote Diabetic Wound Healing in Rats by Increasing VEGF Secretion
Biomed Environ Sci. 2023 Aug 20;36(8):756-759. doi: 10.3967/bes2023.100.NO ABSTRACTPMID:37711087 | DOI:10.3967/bes2023.100
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Su Jing Zhuang Xu Yan Sun Meng Luo Zhong Wang Xue Juan Zhang Zong Sheng Gao Jian Liu Xin Ran Liu Shi Ze Liu Xiao Peng Jia Source Type: research
Cis-regulatory arbitrators of regeneration
Cell Stem Cell. 2023 Sep 6:S1934-5909(23)00295-3. doi: 10.1016/j.stem.2023.08.012. Online ahead of print.ABSTRACTMammals favor healing with scaring over functional tissue regeneration.1 In this issue of Cell Stem Cell, Mack et al. use "super-healer" mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.2.PMID:37714155 | DOI:10.1016/j.stem.2023.08.012
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Piotr Konieczny Shruti Naik Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Lipocalin 2 induces self-limited inhibition of osteoblast differentiation of mesenchymal stem cells
CONCLUSION: Lcn2 is essential for normal osteogenic differentiation of MSCs, but its overexpression and excessive secretion in aging induce self-limited inhibition of osteogenic differentiation of MSCs.PMID:37712270 | PMC:PMC10505573 | DOI:10.12122/j.issn.1673-4254.2023.08.10
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Chen S Li Y Zhang W Yang T Wang Source Type: research
Metformin inhibits self-renewal of colorectal cancer stem cells by inhibiting mitochondrial oxidative phosphorylation
CONCLUSION: Metformin reduces mitochondrial oxidative phosphorylation and ROS levels by inhibiting mitochondrial complex Ⅰ, thereby suppressing Wnt signaling pathway to reduce selfrenewal ability of colorectal CSCs.PMID:37712263 | PMC:PMC10505579 | DOI:10.12122/j.issn.1673-4254.2023.08.03
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: C Yan S Liu Q Song Y Hu Source Type: research
Cancer Stem Cells in Carcinogenesis and Potential Role in Pancreatic Cancer
Curr Stem Cell Res Ther. 2023 Sep 14. doi: 10.2174/1574888X19666230914103420. Online ahead of print.ABSTRACTA poor prognosis is associated with pancreatic cancer because of resistance during treatment and early distant metastases. The discovery of cancer stem cells has opened up novel avenues for research into the biology and treatment of cancer. Many investigations have pointed out the role of these types of stem cells in the oncogenesis and progression of hematologic and solid malignancies, specifically. Due to the existence of cancer stem cells in the proliferation and preservation of pancreatic tumors, such malignancie...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Rishav Sharma Rishabha Malviya Source Type: research
Cis-regulatory arbitrators of regeneration
Cell Stem Cell. 2023 Sep 6:S1934-5909(23)00295-3. doi: 10.1016/j.stem.2023.08.012. Online ahead of print.ABSTRACTMammals favor healing with scaring over functional tissue regeneration.1 In this issue of Cell Stem Cell, Mack et al. use "super-healer" mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.2.PMID:37714155 | DOI:10.1016/j.stem.2023.08.012
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Piotr Konieczny Shruti Naik Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
