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Specialty: Cytology
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Total 78700 results found since Jan 2013.
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM
Cell Mol Life Sci. 2023 Sep 20;80(10):295. doi: 10.1007/s00018-023-04939-w.ABSTRACTRecently, the localization of amyloid precursor protein (APP) into reversible nanoscale supramolecular assembly or "nanodomains" has been highlighted as crucial towards understanding the onset of the molecular pathology of Alzheimer's disease (AD). Surface expression of APP is regulated by proteins interacting with it, controlling its retention and lateral trafficking on the synaptic membrane. Here, we evaluated the involvement of a key risk factor for AD, PICALM, as a critical regulator of nanoscale dynamics of APP. Although it was enriched...
Source: Cellular and Molecular Life Sciences : CMLS - September 19, 2023 Category: Cytology Authors: Vivek Belapurkar H S Mahadeva Swamy Nivedita Singh Shekhar Kedia Subba Rao Gangi Setty Mini Jose Deepak Nair Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis
CONCLUSION: SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis. These findings not only advance our understanding of the molecular mechanisms driving TKI resistance, but also offer novel alternative strategies for the treatment of lung cancer.PMID:37725242 | DOI:10.1007/s00432-023-05416-4
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Fang Huang Jian Cui Jingxuan Wan Xue Yuan Yuanzhe Zhu Xiangxiang Wu Wei Zuo Tiantian Zhao Source Type: research
Featured immune characteristics of COVID-19 and systemic lupus erythematosus revealed by multidimensional integrated analyses
CONCLUSIONS: Our results demonstrate the immune response differences and immune characteristic similarities, such as the cytokine storm, between COVID-19 and SLE, which might pivotally function in the pathogenesis of the two diseases and provide potential intervention targets for both diseases.PMID:37725104 | DOI:10.1007/s00011-023-01791-3
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Xingwang Zhao Mengjie Zhang Yuying Jia Wenying Liu Shifei Li Cuie Gao Lian Zhang Bing Ni Zhihua Ruan Rui Dong Source Type: research
Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases
CONCLUSION: Understanding these mechanisms will contribute to a deeper understanding of the link between neuronal pyroptosis and neurodegenerative diseases, and hold significant implications for the treatment and prevention of neurodegenerative diseases.PMID:37725102 | DOI:10.1007/s00011-023-01790-4
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Ying-Hao Han Xiao-Dong Liu Mei-Hua Jin Hu-Nan Sun Taeho Kwon Source Type: research
A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research
Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
Open Med (Wars). 2023 Sep 12;18(1):20230756. doi: 10.1515/med-2023-0756. eCollection 2023.ABSTRACTHepatocellular carcinoma (HCC) is a frequently diagnosed malignancy with a high mortality rate. Cisplatin (CDDP) is a widely applied anti-cancer drug. However, a large population of liver cancer patients developed CDDP resistance. The polypyrimidine tract binding protein (PTBP1) is an RNA-binding protein involving in progressions of diverse cancers. Here we report PTBP1 was significantly upregulated in liver tumors and cell lines. Silencing PTBP1 effectively sensitized HCC cells to CDDP. From the established CDDP-resistant HCC...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Ruimin Tian Yanfei Li Xiaojie Shen Ying Li Source Type: research
Chronic periodontitis induces the proliferation of pancreatic β-cells to cause hyperinsulinemia in a rat model
CONCLUSION: Our study results link CP-induced hyperinsulinemia with changes in islets, such as islet hyperplasia and compensatory β-cell proliferation, by using a CP rat model.PMID:37723987 | DOI:10.1111/jre.13185
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Leilei Ye Yingtao Lv Qianqi Wu Yiyan Chen Xueyang Zhang Yuan Su Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Efficacy of prompt administration of cryoprecipitate in severe postpartum hemorrhage of preeclampsia patients
CONCLUSION: Prompt replenishment of coagulation factors using CRYO to patients with PE who experience severe PPH could decrease further bleeding.PMID:37723942 | DOI:10.1111/jog.15792
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Keisuke Nakajima Tatsuya Fujii Takayuki Iriyama Mari Ichinose Masatake Toshimitsu Seisuke Sayama Takahiro Seyama Keiichi Kumasawa Toshiyuki Ikeda Yutaka Osuga Source Type: research
Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Said J Cifuentes Maribella Domenech Source Type: research
Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
CONCLUSION: Exosome therapy activates the JNK signaling activation pathway as well as up-regulates Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell death.PMID:37723631 | DOI:10.2174/1574888X19666230918102826
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Ying-Hsien Kao Chih-Yang Chang Yu-Chun Lin Po-Han Chen Po-Huang Lee Huoy-Rou Chang Wen-Yu Chang Yo-Chen Chang Shen-Fa Wun Cheuk-Kwan Sun Source Type: research
Correction
Autophagy. 2023 Sep 19:1. doi: 10.1080/15548627.2023.2260140. Online ahead of print.NO ABSTRACTPMID:37725507 | DOI:10.1080/15548627.2023.2260140
Source: Autophagy - September 19, 2023 Category: Cytology Source Type: research
Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development
Autophagy. 2023 Sep 18. doi: 10.1080/15548627.2023.2259214. Online ahead of print.ABSTRACTColitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic inflammation is considered as the most critical contributor to the development and progression of CAC, with the degree and persistence of the inflammatory response being the primary drivers of CAC progression in individuals with IBD. Macroautophagy/autophagy, which is a cellular process that aids in preserving the intestinal mucosal barrier and regulating intest...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Xuanhong Jin Liangkun You Jincheng Qiao Weidong Han Hongming Pan Source Type: research
