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Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine
The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
Source: Journal of Critical Care - November 3, 2017 Category: Intensive Care Authors: Mohd Basri Mat Nor, Guy A. Richards, Steve McGloughlin, Pravin R. Amin Source Type: research

SCCM Pod-208 PCCM: Hematopoietic Stem Cell Transplant in Children
Margaret Parker, MD, FCCM, speaks with Christine N. Duncan, MD
Source: SCCM PodCast - iCritical Care - March 7, 2013 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

Outcome of Patients with Interstitial Lung Disease Treated with Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.
CONCLUSIONS: ECMO is a lifesaving option for patients with interstitial lung disease and acute respiratory failure provided they are candidates for lung transplantation. ECMO is not able to reverse the poor prognosis in patients that do not qualify for lung transplantation. PMID: 26492547 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 22, 2015 Category: Respiratory Medicine Authors: Trudzinski FC, Kaestner F, Schäfers HJ, Fähndrich S, Seiler F, Böhmer P, Linn O, Kaiser R, Haake H, Langer F, Bals R, Wilkens H, Lepper PM Tags: Am J Respir Crit Care Med Source Type: research

Pediatric Palliative Care and End of Life Outcomes for Pediatric Hematopoietic Stem Cell Transplant Recipients Who Do Not Survive
Hematopoietic Stem Cell Transplant (HSCT) is intensive therapy delivered with curative intent, offering the possibility of cure for life-threatening conditions but with risk of serious complications and death. Whether pediatric palliative care (PPC) consultation is associated with differences in patterns of end of life (EOL) care for children who undergo HSCT and do not survive is unknown.
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Christina Ullrich, Leslie Lehmann, Wendy B. London, Dongjing Guo, Madhumitha Sridharan, Joanne Wolfe Tags: Supportive Care and Nutrition Source Type: research

SCCM Pod-208 PCCM: Hematopoietic Stem Cell Transplant in Children
Margaret Parker, MD, FCCM, speaks with Christine N. Duncan, MD
Source: SCCM PodCast - iCritical Care - March 7, 2013 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

Intensive care management of acute-on-chronic liver failure
AbstractAcute-on-chronic liver failure (ACLF) is a clinical syndrome defined by an acute deterioration of the liver function associated with extrahepatic organ failures requiring intensive care support and associated with a high short-term mortality. ACLF has emerged as a major cause of mortality in patients with cirrhosis and chronic liver disease. ACLF has a unique pathophysiology in which systemic inflammation plays a key role; this provides the basis of novel therapies, several of which are now in clinical trials. Intensive care unit (ICU) therapy parallels that applied in the general ICU population in some organ failu...
Source: Intensive Care Medicine - August 8, 2023 Category: Intensive Care Source Type: research

Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation.
Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation. Am J Respir Crit Care Med. 2013 Jan 10; Authors: Diamond JM, Lee JC, Kawut SM, Shah RJ, Localio AR, Bellamy S, Lederer DJ, Cantu E, Kohl BA, Lama VN, Bhorade S, Crespo M, Demissie E, Sonnett J, Wille K, Orens J, Shah AS, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Ware LB, Palmer SM, Christie JD, for the Lung Transplant Outcomes Group Abstract RATIONALE: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting...
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Diamond JM, Lee JC, Kawut SM, Shah RJ, Localio AR, Bellamy S, Lederer DJ, Cantu E, Kohl BA, Lama VN, Bhorade S, Crespo M, Demissie E, Sonnett J, Wille K, Orens J, Shah AS, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Ware LB, Palmer SM, Christie JD, for th Tags: Am J Respir Crit Care Med Source Type: research

Interferon Gamma Release Assays in the Diagnosis of Latent Tuberculosis Infection Among Immunocompromised Adults.
Abstract Immunocompromised persons with latent tuberculosis infection are at increased risk for tuberculosis reactivation compared to the general population. Tuberculin skin test, the traditional assay for diagnosing LTBI (latent tuberculosis infection), has reduced accuracy in immunocompromised patients. Interferon-gamma release assays (IGRAs) are in vitro blood tests that measure T-cell release of interferon-gamma following stimulation by antigens unique to Mycobacterium tuberculosis. Here we review the data for the use of QuantiFERON-TB Gold In-Tube (QFT-GIT) and T-SPOT.TB, the two currently available IGRAs, in...
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2012 Category: Respiratory Medicine Authors: Redelman-Sidi G, Sepkowitz KA Tags: Am J Respir Crit Care Med Source Type: research

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis.
CONCLUSIONS: Cell death is rare in sepsis-induced cardiac dysfunction but cardiomyocyte injury occurs. Renal tubular injury is common in sepsis but present focally; most renal tubular cells appeared normal. The degree of cell injury and death does not account for severity of sepsis-induced organ dysfunction. PMID: 23348975 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 24, 2013 Category: Respiratory Medicine Authors: Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS Tags: Am J Respir Crit Care Med Source Type: research

Interaction Between Pseudomonas and CXC Chemokines Increases Risk of BOS and Death in Lung Transplantation.
Conclusions Our model demonstrates that common post-transplantation events drive movement from one post-transplantation State to another and influence outcomes differently dependent upon when after transplantation they occur. Furthermore, pseudomonas and the ELR+ CXC chemokines may interact to negatively influence lung transplant outcomes. PMID: 23328531 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Gregson AL, Wang X, Weigt SS, Palchevskiy V, Lynch JP, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA Tags: Am J Respir Crit Care Med Source Type: research

Re-Establishment of Recipient-Associated Microbiota in the Lung Allograft is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome.
CONCLUSIONS: Re-colonization of the allograft by Pseudomonas in CF individuals is not associated with BOS. In general, re-establishment of pre-transplant lung populations in the allograft appears to have a protective effect against BOS, whereas de novo acquisition of microbial populations often belonging to the same genera may increase the risk of BOS. PMID: 23328523 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Willner DL, Hugenholtz P, Yerkovich ST, Tan ME, Daly JN, Lachner N, Hopkins PM, Chambers DC Tags: Am J Respir Crit Care Med Source Type: research

Anaesthesia and intensive care for patients with transmissible diseases
Abstract: Transmissible diseases are a global problem. As the population ages, and as therapies improve, the anaesthetist is increasingly likely to come into contact with affected patients both for surgery and in the intensive care unit (ICU). In this article we outline the epidemiology, clinical features and current treatments of the common blood-borne viruses: hepatitis B and C, and human immunodeficiency and the prion-mediated Creutzfeldt–Jakob disease. We have highlighted the relevance to anaesthetic practice: perioperative and critical care management and the important issue of needlestick injuries. Despite advan...
Source: Anaesthesia and intensive care medicine - February 1, 2013 Category: Anesthesiology Authors: Nicola J. Snook, Muhammad A. Sharafat Tags: Blood Source Type: research

The Use of Lung Allografts from Brain Death Donors After Cardiopulmonary Arrest and Resuscitation.
CONCLUSION: There is no evidence of inferior outcomes following lung transplant from brain death donors who have had a period of cardiac arrest provided that good lung function is preserved and the donor is otherwise deemed acceptable for transplantation. Potential expansion of the donor pool to include cardiac arrest as the cause of brain death requires further study. PMID: 23777361 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 18, 2013 Category: Respiratory Medicine Authors: Castleberry AW, Worni M, Osho AA, Snyder LD, Palmer SM, Pietrobon RS, Davis RD, Hartwig MG Tags: Am J Respir Crit Care Med Source Type: research

Harnessing natural killer cells to protect lung transplants from acute rejection.
PMID: 23767901 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - June 15, 2013 Category: Respiratory Medicine Authors: Shilling RA Tags: Am J Respir Crit Care Med Source Type: research