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A Review of Intravenous Minocycline for Treatment of Multidrug-Resistant Acinetobacter Infections
Options for treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections are extremely limited. Minocycline intravenous is active against many MDR strains of Acinetobacter, and Clinical and Laboratory Standards Institute breakpoints exist to guide interpretation of minocycline susceptibility results with Acinetobacter. In addition, minocycline intravenous holds a US Food and Drug Administration indication for treatment of infections caused by Acinetobacter. There is an accumulating amount of literature reporting successful use of minocycline intravenous for treatment of serious MDR Acinetobacter infections, pa...
Source: Clinical Infectious Diseases - November 4, 2014 Category: Infectious Diseases Authors: Ritchie, D. J., Garavaglia-Wilson, A. Tags: MINOCYCLINE FOR THE TREATMENT OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII Source Type: research

Update on Acinetobacter Species: Mechanisms of Antimicrobial Resistance and Contemporary In Vitro Activity of Minocycline and Other Treatment Options
In this report, we summarized some of the characteristics of the tetracycline class, and quantified the minocycline activity against contemporary (2007–2011) isolates and its potential therapeutic role against a collection of 5477 A. baumannii and other relevant gram-negative organisms when compared directly with tetracycline, doxycycline, and other broad-spectrum antimicrobial agents. Acinetobacter baumannii strains were highly resistant to all agents tested, with the exception of minocycline (79.1% susceptible) and colistin (98.8% susceptible). Minocycline (minimum inhibitory concentration that inhibits 50% and 90%...
Source: Clinical Infectious Diseases - November 4, 2014 Category: Infectious Diseases Authors: Castanheira, M., Mendes, R. E., Jones, R. N. Tags: MINOCYCLINE FOR THE TREATMENT OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII Source Type: research

Epidemiological situation, laboratory capacity and preparedness for carbapenem-resistant Acinetobacter baumannii in Europe, 2019.
ter baumannii capacity survey group Abstract To update information on the epidemiological situation and national capacity for detection, surveillance and containment of carbapenem-resistant Acinetobacter baumannii (CRAb) in Europe, we performed a survey in 37 countries. Nine countries reported regional or inter-regional spread and seven an endemic situation. Laboratories with a reference function, surveillance systems, and a national containment plan for CRAb existed in 30, 23 and eight countries, respectively. A pan-European molecular survey would provide in-depth understanding of the CRAb epidemiology. PMID...
Source: Euro Surveill - November 1, 2020 Category: Infectious Diseases Authors: Lötsch F, Albiger B, Monnet DL, Struelens MJ, Seifert H, Kohlenberg A, European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) carbapenem-resistant Acinetobacter baumannii capacity survey group, EURGen-Net carbapenem-resistant Acinetoba Tags: Euro Surveill Source Type: research

GSE73193 Characterization of two Acinetobacter baumannii rifampin-spontaneous mutants lacking twitching motility
Contributors : Jes ús Aranda Rodríguez ; Jordi Barbé GarcíaSeries Type : Expression profiling by arrayOrganism : Acinetobacter baumannii ; Acinetobacter baumannii ATCC 17978Transcriptional profiling of A. baumannii ATCC 17978 comparing two spontaneous rpoB mutants (Rif5 and Rif 8) with the wild-type parental strain
Source: GEO: Gene Expression Omnibus - June 12, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Acinetobacter baumannii Acinetobacter baumannii ATCC 17978 Source Type: research

GSE89248 Expression data for Acinetobacter baumannii strain AYE and its isogenic protein kinase mutant
Contributors : Vijaya B Srinivasan ; Govindan RajamohanSeries Type : Expression profiling by arrayOrganism : Acinetobacter baumannii ; Acinetobacter baumannii AYETotal RNA isolated from mid-log-grown cultures of A. baumannii and mutant strain in three independent times. Expression profile of A. baumannii and its protein kinase muatant was compared.
Source: GEO: Gene Expression Omnibus - November 10, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Acinetobacter baumannii Acinetobacter baumannii AYE Source Type: research

GSE89247 Expression data for Acinetobacter baumannii strain AYE and its isogenic bacterial tyrosine kinase (byk) mutant
Contributors : Vijaya B Srinivasan ; Govindan RajamohanSeries Type : Expression profiling by arrayOrganism : Acinetobacter baumannii ; Acinetobacter baumannii AYETotal RNA isolated from mid-log-grown cultures of A. baumannii and mutant strain in three independent times. Expression profile of A. baumannii and its byk mutant was compared.
Source: GEO: Gene Expression Omnibus - November 10, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Acinetobacter baumannii Acinetobacter baumannii AYE Source Type: research

GSE96746 RNA-Seq of Benzalkonium Chloride Treated and Untreated Acinetobacter baumannii
Contributors : Bryan W Davies ; Gregory A KnaufSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiThe goal of this RNA-Seq study was to determine Acinetobacter baumannii's transcriptiional response to sub-MIC concentrations of benzalkonium chloride in Acinetobacter baumannii. This RNA-seq data was then utilized to aide in the determination of the sub-MIC mechanism of action for benzalkonium chloride.
Source: GEO: Gene Expression Omnibus - January 23, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research

GSE173396 The abaI/abaR quorum sensing system effects pathogenicity in Acinetobacter baumannii
Contributors : Xiaoyu Sun ; Zhaohui Ni ; Fan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumannii ATCC 17978Acinetobacter baumannii is a Gram-negative pathogen that has emerged as one of the most troublesome pathogens for health care institutions globally. Bacterial quorum sensing (QS) is a process of cell-to-cell communication that relies on the production, secretion and detection of autoinducer (AI) signals to share information about cell density and regulate gene expression accordingly. The molecular and genetic basis of Acinetobacter baumannii virulence remains poorly und...
Source: GEO: Gene Expression Omnibus - April 28, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii ATCC 17978 Source Type: research

GSE181900 Next Generation Sequencing Facilitates Quantitative Analysis of E. coli K-12 LE392, P. putida KT2440, and Acinetobacter baylyi ADP1 Transcriptomes under various antidepressant exposure
Contributors : Ji Lu ; Jianhua Guo ; Pengbo DingSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baylyi ; Escherichia coli ; Pseudomonas putidaThe goals of this study are to use Next-generation sequencing (NGS)to detect bacterial mRNA profiles of E. coli K-12 LE392, P. putida KT2440 and Acinetobacter baylyi ADP1 in response to various antidepressant concentrations for 2 h, in triplicate, using Illumina HiSeq 2500.The NGS QC toolkit (version 2.3.3) was used to treat the raw sequence reads to trim the 3 ’-end residual adaptors and primers, and the ambiguous characters in the reads we...
Source: GEO: Gene Expression Omnibus - August 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baylyi Escherichia coli Pseudomonas putida Source Type: research

GSE218219 Transcriptomic investigation of the modes of action of polymyxins and colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii
Contributors : Xingchen Bian ; Mengyao Li ; Xiaofen Liu ; Yan Zhu ; Jian Li ; Phillip J Bergen ; Wanzhen Li ; Xin Li ; Meiqing Feng ; Jing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiCarbapenem-resistant Acinetobacter baumannii (CRAB) is a Priority 1 (Critical) pathogen urgently requiring new antibiotics. Polymyxins are a last-line option against CRAB-associated infections. This transcriptomic study utilized a CRAB strain to investigate mechanisms of bacterial killing with polymyxin B, colistin, colistin B and colistin/sulbactam combination therapy. After 4 h of 2 ...
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research

GSE100582 Mucin Acts as a Nutrient Source and a Signal for the Differential Expression of Genes Coding for Cellular Processes and Virulence Factors in Acinetobacter baumannii
Contributors : Brock A Arivett ; Emily J Ohneck ; Luis A ActisSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiThe capacity of Acinetobacter baumannii to persist and cause infections depends on its interaction with abiotic and biotic surfaces, including those found on medical devices and host mucosal surfaces. However, the extracellular stimuli affecting these interactions are poorly understood. Based on our previous observations, we hypothesized that mucin, a glycoprotein secreted by lung epithelial cells, particularly during respiratory infections, significantly alters A. ...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research

GSE96745 Tn-Seq of Benzalkonium Chloride Treated and Untreated Acinetobacter baumannii
Contributors : Bryan W Davies ; Gregory A KnaufSeries Type : OtherOrganism : Acinetobacter baumanniiThe goal of this Tn-Seq study was to determine important determinants of Acinetobacter baumannii tolerance of sub-MIC concentrations of benzalkonium chloride. This Tn-seq data was then utilized to aide in the determination of the sub-MIC mechanism of action for benzalkonium chloride.
Source: GEO: Gene Expression Omnibus - January 23, 2018 Category: Genetics & Stem Cells Tags: Other Acinetobacter baumannii Source Type: research

GSE107964 Transcriptomic analysis of paired patient isolates of Acinetobacter baumannii following failed colistin treatment
Contributors : D Deveson Lucas ; J D Boyce ; D PowellSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiColistin is a crucial last-line drug used for the treatment of life-threatening infections caused by multi-drug resistant strains of the Gram-negative bacteria, Acinetobacter baumannii. However, colistin resistant A.  baumannii isolates can be isolated following failed colistin therapy. Resistance is most often mediated by the addition of phosphoethanolamine (pEtN) to lipid A by PmrC, following missense mutations in the pmrCAB operon encoding PmrC and the two-component sign...
Source: GEO: Gene Expression Omnibus - February 19, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research

GSE103244 The primary transcriptome of Acinetobacter baumannii ATCC 17978
Contributors : Carsten Kr öger ; Andrew D CameronSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiTranscriptomics by RNA-seq provides unparalleled insight into bacterial gene expression networks, enabling a deeper understanding of the regulation of pathogenicity, mechanisms of antimicrobial resistance, metabolism, and other cellular processes. Here we present the transcriptome architecture of Acinetobacter baumannii ATCC 17978, a species emerging as a leading cause of antimicrobial resistant nosocomial infections. Differential RNA-seq (dRNA-seq) examination of model strain ...
Source: GEO: Gene Expression Omnibus - June 25, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research

GSE111383 Characterizing Acinetobacter baumannii desiccation tolerance.
Contributors : Bryan Davies ; Xun WangSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiDesiccation tolerance has been implicated as an important characteristic that potentiates the spread of the bacterial pathogen Acinetobacter baumannii through hospitals on dry surfaces. Despite the potential importance of this stress response, scarce information is available describing the underlying mechanisms of A. baumannii desiccation tolerance. Here we characterize the factors influencing desiccation survival of A. baumannii. At the macroscale level, we find that desiccation tolerance...
Source: GEO: Gene Expression Omnibus - October 27, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research