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Total 50632 results found since Jan 2013.

Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis
This research paper describes a new therapeutic candidate based on a nanoparticle that co-delivers siRNA against human epidermal growth factor receptor type 2 (HER2), trastuzumab, and docetaxel to treat advanced HER2+ breast cancer. The nanotherapeutic is more effective and safer than the free drug counterparts. It inhibits drug-resistant orthotopic and brain-metastatic HER2+ breast tumors in mice. AbstractThe first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires two HER2-targeting antibodies (trastuzumab and pertuzumab) and a taxane (docetaxel or pacli...
Source: Small - January 27, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul, Daniel S. Bejan, William Cruz ‐Muñoz, Moataz Reda, Husam Y. Zaidan, Natnaree Siriwon, Suphalak Marshall, Ruijie Wang, Molly A. Nelson, Justin P. C. Rehwaldt, Joe W. Gray, Kullervo Hynynen, Wassana Yantasee Tags: Research Article Source Type: research

Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy.
Abstract The lack of safe and effective gene delivery strategies remains a bottleneck for cancer gene therapy. Here, we describe the synthesis, characterization, and application of cell-penetrating peptide (CPP)-loaded nanobubbles (NBs), which are characterized by their safety, strong penetrating power and high gene loading capability for gene delivery. An epidermal growth factor receptor (EGFR)-targeted small interfering RNA (siEGFR) was transfected into triple negative breast cancer (TNBC) cells via prepared CPP-NBs synergized with ultrasound-targeted microbubble destruction (UTMD) technology. Fluorescence micro...
Source: Colloids and Surfaces - June 20, 2016 Category: Biotechnology Authors: Jing H, Cheng W, Li S, Wu B, Leng X, Xu S, Tian J Tags: Colloids Surf B Biointerfaces Source Type: research

Catheter-directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute pulmonary embolism
CONCLUSIONS: There is a lack of evidence to support widespread adoption of catheter-based interventional therapies for APE. We identified one small trial showing no clear differences between ultrasound-augmented catheter-directed thrombolysis with alteplase plus systemic heparinisation versus systemic heparinisation alone in all-cause mortality, major and minor haemorrhage rates, recurrent APE and length of hospital stay. Quality of life was not assessed. Multiple small retrospective case series, prospective patient registries and single-arm studies suggest potential benefits of catheter-based treatments, but they provide ...
Source: Cochrane Database of Systematic Reviews - August 8, 2022 Category: General Medicine Authors: John J Harvey Shiwei Huang Raman Uberoi Source Type: research

Stem cell-based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants
CONCLUSIONS: No evidence is currently available to evaluate the benefits and harms of stem cell-based interventions for treatment or prevention of GM-IVH or EoP in preterm infants. We identified three ongoing studies, with a sample size range from 20 to 200. In two studies, autologous cord blood mononuclear cells will be administered to extremely preterm infants via the intravenous route; in one, intracerebroventricular injection of MSCs will be administered to preterm infants up to 34 weeks' gestational age.PMID:36790019 | DOI:10.1002/14651858.CD013201.pub3
Source: Cochrane Database of Systematic Reviews - February 15, 2023 Category: General Medicine Authors: Olga Romantsik Alvaro Moreira Bernard Th ébaud Ulrika Ådén David Ley Matteo Bruschettini Source Type: research

Combined oral contraceptive pill for primary dysmenorrhoea
CONCLUSIONS: OCPs are effective for treating dysmenorrhoea, but they cause irregular bleeding, and probably headache and nausea. Long-term effects were not covered in this review. Continuous use of OCPs was probably more effective than the standard regimen but safety should be ensured with long-term data. Due to lack of data, we are uncertain whether NSAIDs are better than OCPs for treating dysmenorrhoea.PMID:37523477 | DOI:10.1002/14651858.CD002120.pub4
Source: Cochrane Database of Systematic Reviews - July 31, 2023 Category: General Medicine Authors: Jeppe B Schroll Amanda Y Black Cindy Farquhar Innie Chen Source Type: research

GoogleFOAM
The expansion of the FOAM world is a bit like blowing up a balloon. The early stages involved a lot of effort for a small increase in size, but as it gets bigger, the resistance is falling away and expansion is getting faster and faster. Obviously this is a good thing. But it can make it easier for us all to get lost and there is the danger of information overload — indeed, I’ve written a guide to (in)sanity in the age of FOAM that I continually update, the LITFL post on Information Overload. The FOAM world is now impossible to keep up with. We need to be able to find what we want when we need it, according to our ...
Source: Life in the Fast Lane - May 17, 2013 Category: Emergency Medicine Doctors Authors: Chris Nickson Tags: Education Emergency Medicine Featured FOAM FOAMed Intensive Care Search Searchengine Social Media Free Open Access Meducation GoogleFOAM medical education search engine Source Type: blogs

A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy
Ultrason Sonochem. 2022 Dec 9;92:106262. doi: 10.1016/j.ultsonch.2022.106262. Online ahead of print.NO ABSTRACTPMID:36512940 | DOI:10.1016/j.ultsonch.2022.106262
Source: Ultrasonics Sonochemistry - December 13, 2022 Category: Chemistry Authors: Gaigai Li Yan Zhang Jinbo Li Source Type: research

Screening for prostate cancer.
CONCLUSIONS: Prostate cancer screening did not significantly decrease prostate cancer-specific mortality in a combined meta-analysis of five RCTs. Only one study (ERSPC) reported a 21% significant reduction of prostate cancer-specific mortality in a pre-specified subgroup of men aged 55 to 69 years. Pooled data currently demonstrates no significant reduction in prostate cancer-specific and overall mortality. Harms associated with PSA-based screening and subsequent diagnostic evaluations are frequent, and moderate in severity. Overdiagnosis and overtreatment are common and are associated with treatment-related harms. Men sh...
Source: Cochrane Database of Systematic Reviews - March 2, 2013 Category: Journals (General) Authors: Ilic D, Neuberger MM, Djulbegovic M, Dahm P Tags: Cochrane Database Syst Rev Source Type: research

"Ultrasound Obstet Gynecol"ta; +669 new citations
669 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Ultrasound Obstet Gynecol"[ta] These pubmed results were generated on 2016/09/21PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: The Ultrasound Review of Obstetrics and Gynecology - September 21, 2016 Category: Radiology Tags: Report Source Type: research

"Ultrasound Obstet Gynecol"ta; +665 new citations
665 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Ultrasound Obstet Gynecol"[ta] These pubmed results were generated on 2017/08/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: The Ultrasound Review of Obstetrics and Gynecology - August 19, 2017 Category: Radiology Tags: Report Source Type: research

Question 1: Is sedation necessary for MRI in an infant?
Scenario A term infant is noted to have frequent seizures during the first day of postnatal life. There are no specific risk factors for infection or hypoxic ischaemic encephalopathy from the maternal or perinatal history. A sepsis evaluation including lumbar puncture, initial metabolic investigations and a cranial ultrasound prove unsupportive of any specific aetiology for the seizures. A neurology consultation is performed and cerebral MRI of the brain is recommended for further diagnostic evaluation. Is there sufficient evidence that imaging without sedation would provide satisfactory image quality? Structured clinical ...
Source: Archives of Disease in Childhood - September 12, 2013 Category: Pediatrics Authors: Halliday, M., Kelleher, J. Tags: ADC Archimedes, Epilepsy and seizures, Pain (neurology), Child health, Pain (palliative care), Radiology, Other anaesthesia, Clinical diagnostic tests, Radiology (diagnostics) Source Type: research