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Total 408183 results found since Jan 2013.

Development and Validation of a Rapid LC-MS/MS based Method to Quantitate Gabapentin and Buprenorphine in Human Serum
CONCLUSIONS: Concentrations of gabapentin and buprenorphine were determined for 5 authentic human serum samples to further validate the utility of the method and applicable to therapeutic drug monitoring beyond its use as a drug screening assay. Furthermore, new mechanisms for the collision-induced dissociation of gabapentin and buprenorphine have been proposed.PMID:33860565 | DOI:10.1002/rcm.9104
Source: Rapid Communications in Mass Spectrometry : RCM - April 16, 2021 Category: Chemistry Authors: Sarah J Phillips Alison Oliveto Michael J Mancino Howard P Hendrickson Source Type: research

Molecules, Vol. 27, Pages 5211: Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices
Yang The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of developing highly sensitive analytical approaches is undeniable. Liquid chromatography tandem mass spectrometry is the preferable technique for the determination of buprenorphine, methadone and their metabolites in biological matrices including urine, plasma, nails or oral fluids. This research aims to review a critical disc...
Source: Molecules - August 16, 2022 Category: Chemistry Authors: Xiaoyue Shan Chengjian Cao Bingsheng Yang Tags: Review Source Type: research

Enhanced electrochemical biosensing of Buprenorphine opioid drug by highly stabilized magnetic nanocrystals
Publication date: February 2017 Source:Sensors and Actuators B: Chemical, Volume 239 Author(s): Abbas Farmany, Mehdi Shamsara, Hossein Mahdavi Herein, we report the synthesis of a spherically stabilized monodisperse magnetic nanocrystal for drug sensing. An optimized ratio of carbon paste material with the magnetic nanocrystal was used for electrochemical sensing of buprenorphine. The buprenorphine cathodic peak current Ip at CS-MNs/CP electrode was 10 fold higher than that of unmodified CP electrode. CS-MNCs/CP electrode is applicable to determine buprenorphine in the linear range of 0.02–68.0μM with a limit of detect...
Source: Sensors and Actuators B: Chemical - August 8, 2016 Category: Chemistry Source Type: research

Molecules, Vol. 26, Pages 437: High-Performance Liquid Chromatography –Tandem Mass Spectrometry for Buprenorphine Evaluation in Plasma—Application to Pharmacokinetic Studies in Rabbits
Molecules, Vol. 26, Pages 437: High-Performance Liquid Chromatography–Tandem Mass Spectrometry for Buprenorphine Evaluation in Plasma—Application to Pharmacokinetic Studies in Rabbits Molecules doi: 10.3390/molecules26020437 Authors: Marta Tikhomirov Błażej Poźniak Tomasz Śniegocki The precise and reliable determination of buprenorphine concentration is fundamental in certain medical or research applications, particularly in pharmacokinetic studies of this opioid. The main challenge is, however, the development of an analytical method that is sensitive enough, as the detected in vivo concentrations ofte...
Source: Molecules - January 15, 2021 Category: Chemistry Authors: Marta Tikhomirov B łażej Poźniak Tomasz Śniegocki Tags: Article Source Type: research

Molecules, Vol. 26, Pages 437: High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Buprenorphine Evaluation in Plasma —Application to Pharmacokinetic Studies in Rabbits
Molecules, Vol. 26, Pages 437: High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Buprenorphine Evaluation in Plasma—Application to Pharmacokinetic Studies in Rabbits Molecules doi: 10.3390/molecules26020437 Authors: Marta Tikhomirov Błażej Poźniak Tomasz Śniegocki The precise and reliable determination of buprenorphine concentration is fundamental in certain medical or research applications, particularly in pharmacokinetic studies of this opioid. The main challenge is, however, the development of an analytical method that is sensitive enough, as the detected in vivo concentrations often ...
Source: Molecules - January 15, 2021 Category: Chemistry Authors: Marta Tikhomirov B łażej Poźniak Tomasz Śniegocki Tags: Article Source Type: research

Buprenorphine and norbuprenorphine determination in mice plasma and brain by gas chromatography-mass spectrometry.
Abstract A gas chromatography tandem mass spectrometry method for quantification of buprenorphine (BUP) and norbuprenorphine (NBUP) in brain and plasma samples from mice was developed and validated. Analytes were extracted from the brain or plasma by solid phase extraction and quantified within 20 minutes. Calibration was achieved by linear regression with a 1/x weighting factor and d4-buprenorphine internal standard. All products were linear from 1 to 2000 ng/mL with a correlation of determination >0.99. Assay accuracy and precision of back-calculated standards were within ±10%. The lower limit of quantificat...
Source: Analytical Chemistry Insights - March 27, 2014 Category: Chemistry Authors: Chiadmi F, Schlatter J Tags: Anal Chem Insights Source Type: research

Fabrication of an ultrasensitive impedimetric buprenorphine hydrochloride biosensor from computational and experimental angles.
Abstract For the first time, an ultrasensitive impedimetric buprenorphine hydrochloride (BN) biosensor based on immobilization of bovine serum albumin (BSA) onto multi-walled carbon nanotubes (MWCNTs)/glassy carbon electrode (BSA/MWCNTs/GCE) has been developed using initial characterization by computational methods and complementing them by experimental observations. Computational results showed that the BSA hydrophobically binds to MWCNTs which is energetically favorable and leads to spontaneous formation of the stable BSA/MWCNTs nanobiocomposite (bioconjugate). Computational results also showed that the interact...
Source: Talanta - May 1, 2014 Category: Chemistry Authors: Gholivand MB, Jalalvand AR, Goicoechea HC, Skov T Tags: Talanta Source Type: research

Synthesis, biological evaluation and radiosynthesis of buprenorphine-derived phenylazocarboxamides as novel μ-opioid receptor ligands.
Abstract Targeted structural modifications led to a novel type of buprenorphine-derived opioid receptor ligands displaying an improved selectivity profile for the μ-OR subtype. On this basis, it is shown that phenylazocarboxamides may serve as useful bioisosteric replacements for widely occuring cinnamide units, without loss of OR binding affinity or subtype selectivity. The present study further includes functional experiments, pointing to weak partial agonist properties of the novel μ-OR ligands, as well as docking and metabolism experiments. Finally, the unique bifunctional character of phenylazocarboxylates,...
Source: ChemMedChem - May 5, 2020 Category: Chemistry Authors: Krüll J, Fehler SK, Hofmann L, Nebel N, Maschauer S, Prante O, Gmeiner P, Lanig H, Hübner H, Heinrich MR Tags: ChemMedChem Source Type: research

Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential
Canadian Journal of Chemistry, Ahead of Print. Novel 1,2,3-triazole-tethered N-norbuprenorphine derivatives with an OMe or OH group at the C3 position were synthesized alongside with evaluation of their analgesic properties. The analgesic activities of the resulting library were investigated via tail flick test in mice. Our results indicated that 10b and 10e were as effective as the starting compounds 8 and 9 with ED50 equal to 16.59 and 19.44  mg/kg, respectively. To investigate the effect of a methyl group at C3 on biological properties, the most active compounds were O-demethylated and their anti-nociceptive effects we...
Source: Canadian Journal of Chemistry - June 8, 2021 Category: Chemistry Authors: Zahra Hasanpour Peyman Salehi Lennart Bunch Mona Khoramjouy Morteza Bararjanian Dan Staerk Mehrdad Faizi Source Type: research

Buprenorphine
In the crystal structure of a semi-synthetic opioid drug buprenorphine, C29H41NO4 {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclopropylmethyl-3-hydroxy-6-methoxy-4,5-epoxy-6,14-ethanomorphinan-7-yl]-3,3-dimethylbutan-2-ol}, the cyclopropylmethyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hydroxy groups is involved in intramolecular O—H...O hydrogen bond. The other hydroxy group acts as a proton donor in an intermolecular O—H...O interaction that connects molecules into a zigzag chain along the b axis.
Source: Acta Crystallographica Section E - May 3, 2014 Category: Chemistry Authors: Mazurek, J.Hoffmann, M.Fernandez Casares, A.Cox, P.D.Minardi, M.D. Tags: organic compounds Source Type: research

INFERYS Rescoring: boosting peptide identifications and scoring confidence of database search results
Rapid Commun Mass Spectrom. 2021 May 20:e9128. doi: 10.1002/rcm.9128. Online ahead of print.ABSTRACTDatabase search engines for bottom-up proteomics largely ignore peptide fragment ion intensities during the automated scoring of tandem mass spectra against protein databases. Recent advances in deep learning allow the accurate prediction of peptide fragment ion intensities. Using these predictions to calculate additional intensity-based scores help to overcome this drawback. Here, we describe a processing workflow termed INFERYS™ Rescoring for the intensity-based rescoring of Sequest HT search engine results in Thermo Sci...
Source: Rapid Communications in Mass Spectrometry : RCM - May 20, 2021 Category: Chemistry Authors: Daniel P Zolg Siegfried Gessulat Carmen Paschke Michael Graber Magnus Rathke-Kuhnert Florian Seefried Kai Fitzemeier Frank Berg Daniel Lopez-Ferrer David Horn Christoph Henrich Andreas Huhmer Bernard Delanghe Martin Frejno Source Type: research