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Total 419 results found since Jan 2013.

Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy
Diabetes Metab J. 2023 Sep 6. doi: 10.4093/dmj.2023.0018. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes. The lifetime prevalence of DPN is thought to be >50%, and 15%-25% of patients with diabetes experience neuropathic pain, referred to as "painful DPN." Appropriate treatment of painful DPN is important because this pain contributes to a poor quality of life by causing sleep disturbance, anxiety, and depression. The basic principle for the management of painful DPN is to control hyperglycemia and other modifiable risk factors, but these...
Source: Diabetes and Metabolism Journal - September 6, 2023 Category: Endocrinology Authors: Han Na Jang Tae Jung Oh Source Type: research

Gene Therapy Targets Chronic Pain
Scientists at New York University have developed a gene therapy for chronic pain. The technology works by targeting the NaV1.7 sodium ion channel present on neurons, which is an important component of the pain response. The researchers encoded a vers...
Source: Medgadget - August 25, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine Pain Management chronic pain nyu Source Type: blogs

Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations
Curr Pain Headache Rep. 2023 Aug 16. doi: 10.1007/s11916-023-01151-0. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Although the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to minimize migraine symptoms. It is important to understand the role of these medications as options for migraine treatment and the varied mechanisms by which symptoms can be addressed. In the present investigation, the role of non-CGRP antagonist/non-triptan options for migraine disease therapy is reviewed, including NSAIDs, ß-blockers, calcium channel blockers, antidepressants, and ...
Source: Pain Physician - August 16, 2023 Category: Anesthesiology Authors: Ellen E Ingram Brooke E Bocklud Sarah C Corley Mallory A Granier Elisa E Neuchat Shahab Ahmadzadeh Sahar Shekoohi Alan D Kaye Source Type: research

Vasodilators For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion In summary, vasodilators play a pivotal role in managing cardiovascular conditions, including hypertension, which is rapidly becoming a global health concern. By expanding the body’s blood vessels, these unique medications can improve blood flow and decrease the pressure exerted by the heart, thereby providing relief to numerous patients worldwide. Their applications are diverse, extending beyond hypertension to conditions like angina, heart failure, and even erectile dysfunction. However, these medications should be taken carefully and always under the supervision of a doctor due to the potent...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

A man in his 70s with weakness and syncope
DiscussionBrugada Type 1 ECG changes are associated with sudden cardiac death (SCD) and the occurrence of ventricular dysrhythmias. Patients that develop a Type 1 pattern without any precipitating or provoking factors have a risk of SCD of 0.5-0.8% per year. In patients that only have this pattern induced by a sodium channel blocking agent have a lower rate of SCD (0 - 0.35% per year)[1]. Drugs that have been associated with Brugada ECG patterns include tricyclic antidepressants, anesthetics, cocaine, methadone, antihistamines, electrolyte derangements, and even tramadol. [2]. Our patient had a Brugada Type ...
Source: Dr. Smith's ECG Blog - July 22, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

Blood Pressure Meds vs Blood Thinners: What ’ s The Difference?
Conclusion In conclusion, while blood pressure medicines and blood thinners are both crucial to heart health, their roles and mechanisms of action are notably distinct. Blood pressure medication works primarily on the vascular system, aiding in reducing blood pressure by relaxing blood vessels or altering the heart’s function. On the other hand, blood thinners target the blood itself, working to prevent the formation of potentially dangerous blood clots. Throughout this article, one thing becomes undeniably clear: the importance of regular consultations with your healthcare provider. When it comes to managing m...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Inpatient Management of Decompensated Cirrhosis
In this clinical-pearl-packed session, Dr. Suchita Shah Sata from Duke University Hospital in Durham, N.C., recaps the breadth of knowledge needed by hospitalists to manage this complex patient population. Outlining the objectives of the talk, Dr. Sata describes the pathophysiology of cirrhosis and how this leads to the complications that are seen in the decompensated state, suggests a framework for evaluating the etiologies of decompensated cirrhosis, and applies current evidence to delineate best practices in inpatient management of common complications of cirrhosis. Reviewing the pathophysiology of decompensated cirrhos...
Source: The Hospitalist - July 5, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Liver Disease Source Type: research

Pharmacologic Management of Cancer-Related Pain in Pregnant Patients
The objective of this review is to provide clinicians with an understanding of pain experienced by pregnant patients with cancer and medications that may be used to help manage cancer-related pain. Nociceptive pain results from damage to somatic or visceral tissues that may be directly caused by cancer. This type of pain can be managed in pregnant patients using acetaminophen and/or nonsteroidal antiinflammatory drugs as first-line agents. In nociceptive pain not managed by non-opioid analgesics, buprenorphine is recommended for those requiring chronic opioids to help manage their pain. Neuropathic pain that results from d...
Source: Drugs - June 22, 2023 Category: Drugs & Pharmacology Source Type: research

Can You Try Cryotherapy With Hypertension?
Conclusion Returning to our original query: Can you try cryotherapy with hypertension? The answer is nuanced—it’s a cautious ‘maybe.’ While some research suggests a transient increase in blood pressure, it’s paramount to consult your healthcare provider and closely monitor your response to the treatment. After all, when it comes to managing health conditions, no stone should be left unturned. Read also: Can You Practice Tai Chi With Hypertension? Reference Cardiovascular and autonomic responses to whole-body cryostimulation in essential hypertension. https://pubmed.ncbi.nlm.nih.gov/25108050/
Source: The EMT Spot - June 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs