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Activation of TREK-1 (K < sub > 2P < /sub > 2.1) Potassium Channels Protects Against Influenza A-Induced Lung Injury
Am J Physiol Lung Cell Mol Physiol. 2022 Nov 21. doi: 10.1152/ajplung.00116.2022. Online ahead of print.ABSTRACTInfluenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in 300,000-650,000 deaths. Preventive vaccination programs and antiviral medications represent the mainstay of therapy, but with unacceptably high morbidity and mortality rates new targeted therapeutic approaches are urgently needed. Since inflammatory processes are commonly associated with measurable changes in cell membrane potential (Em), we investigated whether Em hyperpolarization via TREK-1 (K2P2.1) K+ channel activa...
Source: Am J Physiol Lung Ce... - November 21, 2022 Category: Respiratory Medicine Authors: Tatiana Zyrianova Benjamin Lopez Kathlyn Zou Charles Gu Dayna Pham Sriharsha Talapaneni Christopher M Waters Riccardo Olcese Andreas Schwingshackl Source Type: research

Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all. Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs