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A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis
Innate Immun. 2021 Apr;27(3):266-274. doi: 10.1177/17534259211007538.ABSTRACTDespite the dramatic increase in antimicrobial resistance, there is a dearth of antibiotics in development and few pharmaceutical companies working in the field. Further, any new antibiotics are likely to have a short shelf life. Ab-based interventions offer alternatives that are not likely to be circumvented by the widely prevalent antibiotic resistance genes. Bovine colostrum (BC)-the first milk after parturition, rich in nutrients and immune components-promotes gut integrity and modulates the gut microbiome. We developed a hyperimmune BC (HBC) ...
Source: Innate Immunity - April 16, 2021 Category: Allergy & Immunology Authors: Alan S Cross Steven M Opal John E Palardy Surekha Shridhar Scott M Baliban Alison J Scott Abdullah B Chahin Robert K Ernst Source Type: research

Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating th...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research