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Nutrition: Iron
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Total 938 results found since Jan 2013.
Impact of ferroptosis on preeclampsia: A review
Biomed Pharmacother. 2023 Sep 18;167:115466. doi: 10.1016/j.biopha.2023.115466. Online ahead of print.ABSTRACTPreeclampsia (PE) is usually associated with the accumulation of reactive oxygen species (ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid peroxidation-induced iron-dependent cell death distinct from traditional apoptosis, necroptosis, and pyroptosis and most likely contributes considerable to PE pathogenesis. At approximately 10-12 weeks of gestation, trophoblasts create an environment rich in oxygen and iron. In patients with PE, ferroptosis-related genes such as HIF1 an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Yuping Shan Chengcheng Guan Jingli Wang Weihong Qi Aiping Chen Shiguo Liu Source Type: research
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
In this study, we investigated the therapeutic effects of fisetin against fibrotic kidney disease and the underlying mechanisms. We established adenine diet-induced and unilateral ureteral obstruction (UUO)-induced CKD models in adult male mice. The two types of mice were administered fisetin (50 or 100 mg·kg-1·d-1, i.g.) for 3 weeks or 7 days, respectively. At the end of the experiments, the mice were euthanized, and blood and kidneys were gathered for analyzes. We showed that fisetin administration significantly ameliorated tubular injury, inflammation, and tubulointerstitial fibrosis in the two types of CKD mice. In m...
Source: Acta Pharmacologica Sinica - September 11, 2023 Category: Drugs & Pharmacology Authors: Bo Wang Li-Na Yang Le-Tian Yang Yan Liang Fan Guo Ping Fu Liang Ma Source Type: research
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment
In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity. The SOR-SIM combination exhibited a synergistic effect in MDA-MB-231, A549, and HeLa cells, with calculated CI values of ~ 0.66, 0.53, and 0.59, respectively. Furthermore, co-treatment with ferrostatin-1 resulted in a concentration-dependent increase in the IC50 values. Additionally, SOR + SIM demonstrated a significant reduction in GSH levels, an increase in MDA levels, and mitochondrial membrane depolar...
Source: AAPS PharmSciTech - September 11, 2023 Category: Drugs & Pharmacology Authors: Kaushik Kuche Vivek Yadav Meet Patel Rohan Ghadi Sanyog Jain Source Type: research
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
In this study, we investigated the therapeutic effects of fisetin against fibrotic kidney disease and the underlying mechanisms. We established adenine diet-induced and unilateral ureteral obstruction (UUO)-induced CKD models in adult male mice. The two types of mice were administered fisetin (50 or 100 mg·kg-1·d-1, i.g.) for 3 weeks or 7 days, respectively. At the end of the experiments, the mice were euthanized, and blood and kidneys were gathered for analyzes. We showed that fisetin administration significantly ameliorated tubular injury, inflammation, and tubulointerstitial fibrosis in the two types of CKD mice. In m...
Source: Acta Pharmacologica Sinica - September 11, 2023 Category: Drugs & Pharmacology Authors: Bo Wang Li-Na Yang Le-Tian Yang Yan Liang Fan Guo Ping Fu Liang Ma Source Type: research
Rosiglitazone inhibits acyl-CoA synthetase long-chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury
This study aimed to investigate the role of ACSL4 in SBI via the ferroptosis pathway. Ninety male Sprague-Dawley rats were examined using a model of SBI. Subsequently, the inhibitory effect of rosiglitazone on ACSL4 was assessed via western blot, real-time polymerase chain reaction (PCR), immunofluorescence, fluoro-jade C staining, Perl's staining, ROS assay, and neurological scoring. The results showed that compared with the Sham group, the protein levels of ACSL4 and transferrin were significantly increased after SBI. Administration of rosiglitazone significantly reduced neuronal necrosis, iron deposition, brain water co...
Source: Clinical and Experimental Pharmacology and Physiology - September 7, 2023 Category: Drugs & Pharmacology Authors: Jinchao Shen Min Qian Muyao Wu Jiafeng Tang Yating Gong Jie Li Jinfen Ji Baoqi Dang Source Type: research
Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes
In conclusion, our findings demonstrate that induction of adipocyte inflammation disrupts iron homeostasis, resulting in adipocyte iron overload.PMID:37677967 | DOI:10.1016/j.biopha.2023.115428
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: N úria Oliveras-Cañellas Jessica Latorre Elena Santos-Gonz ález Aina Lluch Francisco Ortega Jordi Mayneris-Perxachs Jos é-Manuel Fernández-Real Jos é María Moreno-Navarrete Source Type: research
Rosiglitazone inhibits acyl-CoA synthetase long-chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury
This study aimed to investigate the role of ACSL4 in SBI via the ferroptosis pathway. Ninety male Sprague-Dawley rats were examined using a model of SBI. Subsequently, the inhibitory effect of rosiglitazone on ACSL4 was assessed via western blot, real-time polymerase chain reaction (PCR), immunofluorescence, fluoro-jade C staining, Perl's staining, ROS assay, and neurological scoring. The results showed that compared with the Sham group, the protein levels of ACSL4 and transferrin were significantly increased after SBI. Administration of rosiglitazone significantly reduced neuronal necrosis, iron deposition, brain water co...
Source: Clinical and Experimental Pharmacology and Physiology - September 7, 2023 Category: Drugs & Pharmacology Authors: Jinchao Shen Min Qian Muyao Wu Jiafeng Tang Yating Gong Jie Li Jinfen Ji Baoqi Dang Source Type: research
Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes
In conclusion, our findings demonstrate that induction of adipocyte inflammation disrupts iron homeostasis, resulting in adipocyte iron overload.PMID:37677967 | DOI:10.1016/j.biopha.2023.115428
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: N úria Oliveras-Cañellas Jessica Latorre Elena Santos-Gonz ález Aina Lluch Francisco Ortega Jordi Mayneris-Perxachs Jos é-Manuel Fernández-Real Jos é María Moreno-Navarrete Source Type: research
Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research
Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease
In this study, we investigated the involvement of α-synuclein and iron in the process of cell senescence in a mouse model of PD. In order to overexpress α-syn-A53T in the substantia nigra pars compacta (SNpc), human α-syn-A53T was microinjected into both sides of the SNpc in mice. We found that overexpression of α-syn-A53T for one week induced significant pro-inflammatory senescence-associated secretory phenotype (SASP), increased cell senescence-related proteins (β-gal, p16, p21, H2A.X and γ-H2A.X), mitochondrial dysfunction accompanied by dysregulation of iron-related proteins (L-ferritin, H-ferritin, DMT1, IRP1 an...
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Qing-Qing Shen Xian-Hui Jv Xi-Zhen Ma Chong Li Lin Liu Wen-Ting Jia Le Qu Lei-Lei Chen Jun-Xia Xie Source Type: research
Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research
Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease
In this study, we investigated the involvement of α-synuclein and iron in the process of cell senescence in a mouse model of PD. In order to overexpress α-syn-A53T in the substantia nigra pars compacta (SNpc), human α-syn-A53T was microinjected into both sides of the SNpc in mice. We found that overexpression of α-syn-A53T for one week induced significant pro-inflammatory senescence-associated secretory phenotype (SASP), increased cell senescence-related proteins (β-gal, p16, p21, H2A.X and γ-H2A.X), mitochondrial dysfunction accompanied by dysregulation of iron-related proteins (L-ferritin, H-ferritin, DMT1, IRP1 an...
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Qing-Qing Shen Xian-Hui Jv Xi-Zhen Ma Chong Li Lin Liu Wen-Ting Jia Le Qu Lei-Lei Chen Jun-Xia Xie Source Type: research
Recent advances of ferroptosis in tumor: From biological function to clinical application
Biomed Pharmacother. 2023 Sep 2;166:115419. doi: 10.1016/j.biopha.2023.115419. Online ahead of print.ABSTRACTFerroptosis is a recently recognized form of cell death with distinct features in terms of morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death, ferroptosis is characterized by iron dependence, reactive oxygen species accumulation and lipid peroxidation. Recent studies have demonstrated that selective autophagy plays a vital role in the induction of ferroptosis, including ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy. Emerging evidence has indicated the invo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2023 Category: Drugs & Pharmacology Authors: Shunfeng Hu Yurou Chu Xiangxiang Zhou Xin Wang Source Type: research
