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Total 259 results found since Jan 2013.
Effects and mechanism of Kedaling tablets for atherosclerosis treatment based on network pharmacology, molecular docking and experimental study
CONCLUSIONS: KDL attenuated AS in ApoE-/- mice, which was associated with a suppression of inflammatory signalling through the TNF and TGF-β pathways.PMID:37657772 | DOI:10.1016/j.jep.2023.117108
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Hongzheng Li Wenwen Yang Weiyi Cao Zikai Yu Guoyuan Zhang Linzi Long Hao Guo Hua Qu Changgeng Fu Keji Chen Source Type: research
The role of cepharanthine as an anti-atherosclerotic agent in rats
Pak J Pharm Sci. 2023 Jul;36(4):1073-1077.ABSTRACTThis investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established: a high-fat high sucrose diet (HFHS), HFHS supplemented with intraperitoneal cepharanthine (HFHS-C) or oral atorvastatin (HFHS-A) from the 8th week, and a normal-fat diet (NFD). The study aimed to evaluate diet and drug impact on aortic histopathological changes over 16 weeks. Our results revealed significant atherosclerosis...
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: - Adnan Iqbal - Rahila Najam - Saira Saeed Khan - Sumera Imran - Muhammad Osama - Anosh Tahir - Muhammad Imran - Bilal Jawed - Zeeshan Ahmed - Azfar Athar Ishaqui Source Type: research
Xinmaikang-mediated mitophagy attenuates atherosclerosis via the PINK1/Parkin signaling pathway
CONCLUSION: The study shows that XMK is effective against AS by mediating macrophage mitophagy via the PINK1/Parkin signaling pathway. For the treatment of AS and drug discovery, it provides an experimental basis and target.PMID:37572567 | DOI:10.1016/j.phymed.2023.154955
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Yanhong Cao Xin Chen Fuqiang Pan Mingyang Wang Haowen Zhuang Jiangna Chen Lu Lu Lingjun Wang Ting Wang Source Type: research
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: European Journal of Pharmacology - August 3, 2023 Category: Drugs & Pharmacology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research
Combined with multiplex and network analysis to reveal the key genes and mechanisms of nonalcoholic fatty liver disease
CONCLUSIONS: In conclusion, our study constructed the NAFLD gene regulatory network of C57BL/6J mice for the first time and jointly analyzed the Mus musculus samples and Homo sapiens samples. It provides new insights for identifying potential biomarkers and valuable therapeutic clues, and puts forward a new method for web-based research. These findings may provide potential targets for early diagnosis, effective therapy and prognostic markers of NAFLD.PMID:37523974 | DOI:10.1016/j.intimp.2023.110708
Source: International Immunopharmacology - July 31, 2023 Category: Allergy & Immunology Authors: Zhao Yang Xuebing Han Keyu Wang Jun Fang Zheng Wang Gang Liu Source Type: research
Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model
This study aimed to explore the intervention effect of Chuanxiong-Chishao herb pair(CX-CS) on a myocardial infarction-atherosclerosis(MI-AS) mouse model and investigate its effect on the expression profile of circular RNAs(circRNAs)/long non-coding RNAs(lncRNAs) in ischemic myocardium and aorta. Sixty male ApoE~(-/-) mice were randomly assigned to a model group, high-, medium-, and low-dose CX-CS groups(7.8, 3.9, and 1.95 g·kg~(-1)), and a positive drug group(metoprolol 26 mg·kg~(-1) and simvastatin 5.2 mg·kg~(-1)), with 12 mice in each group. Male C57BL/6J mice were assigned to the sham group. The mice in the model gro...
Source: Atherosclerosis - July 20, 2023 Category: Cardiology Authors: Rong Yuan Zi-Han Li Mei-Wen Huang Peng-Qi Li Yu Miao Hui Mo Li Zeng Zhen-Yu Ju Qi-Qi Xin Wei-Hong Cong Source Type: research
Synthesis, characterization and hypolipidemic effects of urazine derivatives on rat: Study of molecular modeling and enzyme inhibition
Bioorg Chem. 2023 Jun 16;139:106681. doi: 10.1016/j.bioorg.2023.106681. Online ahead of print.ABSTRACTThe prevalence of hyperlipidemia has increased dramatically worldwide. It is a major public health threat, characterized by the presence of an abnormal lipid profile, primarily with elevated serum total cholesterol (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) levels, and reduced high-density lipoprotein (HDL) level. Genetic factors, dietary and lifestyle habits play important roles in hyperlipidemia. It can increase the risk of chronic metabolic disorders, such as obesity, cardiovascular disease...
Source: Bioorganic Chemistry - June 29, 2023 Category: Chemistry Authors: Faramarz Jalili Cyrus Jalili Ali R Jalalvand Nader Salari Ali Pourmotabbed Hadi Adibi Source Type: research
Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells
CONCLUSION: These data establish a novel mechanism by which a pathogenic missense variant in a smooth muscle-specific contractile protein predisposes to atherosclerosis in individuals without hypercholesterolemia or other risk factors. The results emphasize the role of increased intracellular cholesterol levels in driving SMC phenotypic modulation and atherosclerotic plaque burden.PMID:37377039 | DOI:10.1093/eurheartj/ehad373
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Kaveeta Kaw Abhijnan Chattopadhyay Pujun Guan Jiyuan Chen Suravi Majumder Xue-Yan Duan Shuangtao Ma Chen Zhang Callie S Kwartler Dianna M Milewicz Source Type: research
Pleiotropic effects of Salacia reticulata and Simvastatin on oxidative stress and insulin resistance in a rat model
CONCLUSIONS: The present study confirms that SR/SVS may be a new and promising remedial approach because of its beneficial effects on the pathophysiological processes of obesity and related metabolic disorders.PMID:37290186 | DOI:10.1016/j.biopha.2023.114960
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 8, 2023 Category: Drugs & Pharmacology Authors: Sudhakara Gujjala Manjunatha Bangeppagari Venkata Lakshmi Narasimha Prasad Devarakonda Ramesh Bellamkonda Ramu Bhadramraju Srinivasan Kameswaran Rajendran Ramaswamy Saralakumari Desireddy Source Type: research
