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Total 191 results found since Jan 2013.
Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy
Cell Mol Immunol. 2023 Sep 5. doi: 10.1038/s41423-023-01080-3. Online ahead of print.ABSTRACTSolid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to developing severe COVID-19. Here, we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients (n = 136) treated with different ISDs. We demonstrate that a combination of a calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and prednisone (Pred) treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response. Such defects have clinical consequences bec...
Source: Cellular and Molecular Immunology - September 4, 2023 Category: Molecular Biology Authors: Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Source Type: research
Immune responses and safety of COVID-19 vaccination in atypical hemolytic uremic syndrome patients in Taiwan
Vaccine. 2023 Aug 25:S0264-410X(23)00952-0. doi: 10.1016/j.vaccine.2023.08.020. Online ahead of print.ABSTRACTAtypical hemolytic uremic syndrome is a rare, life-threatening disorder which can be triggered by COVID 19 infection and COVID 19 vaccination then induce multiple organ failure. Our study is the first to evaluate immune responses to COVID-19 vaccination and safety in a cohort of patients in a local single-center study in Taiwan.. Results indicate that vaccines effectively shield aHUS patients from severe COVID-19 complications without significant safety concerns. A double booster dose for the third vaccine is essen...
Source: Vaccine - August 27, 2023 Category: Allergy & Immunology Authors: I-Ru Chen Guei-Jane Wang Po-Ren Hsueh Chia-Hui Chou Long-Bin Jeng Hui-Ju Lin Huang-Jiun Liao Ping-Chin Lai Jan-Gowth Chang Chiu-Ching Huang Source Type: research
Identification of neutralizing epitopes on the D/A domain of the E2 glycoprotein of classical swine fever virus
Virus Res. 2023 Aug 24:199209. doi: 10.1016/j.virusres.2023.199209. Online ahead of print.ABSTRACTClassical swine fever virus (CSFV) shares high antigenic homology with other members of the genus Pestivirus. Because several pestivirus species can also infect swine, eliciting cross-reactive antibodies, it is important to define CSFV-specific epitopes for the differential diagnosis of classical swine fever (CSF) by serology. For this purpose, epitope mapping of seven monoclonal antibodies (mAbs), recognizing sites on the D/A domain of glycoprotein E2, was performed using recombinant expressed antigenic domains and mutants of...
Source: Virus Research - August 26, 2023 Category: Virology Authors: Yu-Liang Huang Denise Meyer Alexander Postel Kuo-Jung Tsai Hsin-Meng Liu Chia-Huei Yang Yu-Chun Huang Hui-Wen Chang Ming-Chung Deng Fun-In Wang Paul Becher Helen Crooke Chia-Yi Chang Source Type: research
