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Nutrition: Antidoxidants
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Total 4780 results found since Jan 2013.
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Cell Mol Immunol. 2023 Sep 22. doi: 10.1038/s41423-023-01084-z. Online ahead of print.ABSTRACTInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases. Here, we show that V-set and transmembrane domain-containing 1 (VSTM1) is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1 (Gal1) is essential for maintaining neutrophil viability mediated by downregulated reactive...
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C Tsokos Minghong Jiang Xuan Zhang Source Type: research
Catechin hydrate ameliorates cerulein ‑induced chronic pancreatitis via the inactivation of TGF‑β/Smad2 signaling
Mol Med Rep. 2023 Nov;28(5):208. doi: 10.3892/mmr.2023.13095. Epub 2023 Sep 21.ABSTRACTChronic pancreatitis (CP) is a pancreatic inflammatory disease associated with histological changes, including fibrosis, acinar cell loss and immune cell infiltration, and leads to damage of the pancreas, which results in pain, weight loss and loss of pancreas function. Catechin or catechin hydrate (CH) has antioxidant, anticancer and immune‑regulatory effects. However, unlike other catechins, the antifibrotic effects of (+)‑CH have not been widely studied in many diseases, including CP. Therefore, the anti‑fibrotic effects of (+)â...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Bitna Kweon Dong-Uk Kim Jin-Young Oh Sung-Joo Park Gi-Sang Bae Source Type: research
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL < sup > Pro < /sup >
RSC Med Chem. 2023 Jan 3;14(9):1667-1697. doi: 10.1039/d2md00394e. eCollection 2023 Sep 19.ABSTRACTA novel class of bioactive complexes (1-3) [MII(L)2(bpy)], where, L = 2-(4-morpholinobenzylideneamino)phenol, bpy = 2,2'-bipyridine, MII = Mn (1), Co (2) or Ni (3), were assigned to octahedral geometry based on analytical and spectral measurements. Gel electrophoresis showed that complex (2) demonstrated significant DNA cleavage activity compared to the other complexes under the action of oxidation agent (H2O2). The DNA binding constant properties measured by various techniques were in the following sequence: (2) > (3) >...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Karunganathan Sakthikumar Bienfait Kabuyaya Isamura Rui Werner Ma çedo Krause Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
CONCLUSION: The intellectual disability of moderate type (MID) was associated with abnormal changes in the levels of essential mineral elements and adipokines and increased levels of cellular oxidative stress. Thus, evaluating plasma mineral elements and adipokines levels could be a potential diagnostic parameter for diagnosing MID.PMID:37730529 | PMC:PMC10512604 | DOI:10.1186/s12860-023-00490-5
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Ahmad H Alghadir Sami A Gabr Amir Iqbal Source Type: research
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Alth...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasan G ündoğar Hakan Özdemir Zeynep Deniz Şahin İnan Source Type: research
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1 α- and NLRP3-derived IL-1β secretion in macrophages
This study demonstrated that resveratrol significantly improved the symptoms of acute gouty arthritis and its potential mechanism may be IL-1β reduction via HIF-1α modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.PMID:37715438 | DOI:10.14715/cmb/2023.69.7.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yamen Wang Wei Li Tianhan Zhang Runmei Wang Tao Wang Qingyun Xie Meng Wei Source Type: research
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Alth...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasan G ündoğar Hakan Özdemir Zeynep Deniz Şahin İnan Source Type: research
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1 α- and NLRP3-derived IL-1β secretion in macrophages
This study demonstrated that resveratrol significantly improved the symptoms of acute gouty arthritis and its potential mechanism may be IL-1β reduction via HIF-1α modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.PMID:37715438 | DOI:10.14715/cmb/2023.69.7.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yamen Wang Wei Li Tianhan Zhang Runmei Wang Tao Wang Qingyun Xie Meng Wei Source Type: research
