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What does the historic settlement won by Henrietta Lacks ’s family mean for others?
Last week, the family of Henrietta Lacks settled its lawsuit against the huge biotechnology company Thermo Fisher Scientific over its claim that the company had been “unjustly enriched” by its use of her cells. Lacks was a Black woman who died of cervical cancer in 1951, soon after a doctor took a sample from her tumor without her knowledge or consent and created an immortal cell line, HeLa. No financial payments or other terms of the settlement were disclosed, and no judge ruled on the fundamentals of the unusual claim. But some have nevertheless hailed it as precedent setting. And the family ’ s la...
Source: Science of Aging Knowledge Environment - August 7, 2023 Category: Geriatrics Source Type: research

Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination
This study indicates that CD33/Siglec-3 may serve as a predictor of HIV-1 control and as potential therapeutic tool to improve future cure strategies.FUNDING: Spanish Science and Innovation Ministry (SAF2017-89726-R and PID2020-119710RB-I00), NIH (P01-AI131568), European Commission (GA101057548) and a Grifols research agreement.PMID:37506557 | DOI:10.1016/j.ebiom.2023.104732
Source: Cancer Control - July 28, 2023 Category: Cancer & Oncology Authors: Clara Duran-Castells Anna Prats Bruna Oriol-Tordera Anuska Llano Cristina Galvez Javier Martinez-Picado Ester Ballana Edurne Garcia-Vidal Bonaventura Clotet Jose A Mu ñoz-Moreno Thomas Hanke Jos é Moltó Beatriz Mothe Christian Brander Marta Ruiz-Riol Source Type: research

Head-to-head immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil 9 in women aged 18-26 years in China: a randomised blinded clinical trial
This study aimed to compare the immunogenicity of the E coli-produced HPV 9-valent vaccine Cecolin 9 (against HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) with Gardasil 9.METHODS: This was a randomised, single-blind trial conducted in China. Healthy non-pregnant women aged 18-26 years, who were not breastfeeding and with no HPV vaccination history, were enrolled in the Ganyu Centre for Disease Control and Prevention (Lianyungang City, Jiangsu Province, China). Women were stratified by age (18-22 years and 23-26 years) and randomly assigned (1:1) using a permutated block size of eight to receive three doses of Cecolin 9 or Ga...
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Feng-Cai Zhu Guo-Hua Zhong Wei-Jin Huang Kai Chu Li Zhang Zhao-Feng Bi Kong-Xin Zhu Qi Chen Ting-Quan Zheng Ming-Lei Zhang Sheng Liu Jin-Bo Xu Hong-Xing Pan Guang Sun Feng-Zhu Zheng Qiu-Fen Zhang Xiu-Mei Yi Si-Jie Zhuang Shou-Jie Huang Hui-Rong Pan Ying-Y Source Type: research

Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study
EClinicalMedicine. 2023 Jun 29;61:102044. doi: 10.1016/j.eclinm.2023.102044. eCollection 2023 Jul.ABSTRACTBACKGROUND: The prospective multicentre observational INVIDIa-2 study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving immune checkpoint inhibitors (ICI). In this secondary analysis of the original trial, we aimed to assess the outcomes of patients to immunotherapy based on vaccine administration.METHODS: The original study enrolled patients with advanced solid tumours receiving ICI at 82 Italian Oncology Units from Oct 1, 2019, to Jan 31, 2020. The trial's pri...
Source: Cancer Control - July 12, 2023 Category: Cancer & Oncology Authors: Melissa Bersanelli Elena Verzoni Alessio Cortellini Raffaele Giusti Lorenzo Calvetti Paola Ermacora Marilena Di Napoli Annamaria Catino Valentina Guadalupi Giorgia Guaitoli Vieri Scotti Francesca Mazzoni Antonello Veccia Pamela Francesca Guglielmini Fabia Source Type: research

Immune response after two doses of the BNT162b2 COVID-19 vaccine and risk of SARS-CoV-2 breakthrough infection in Tyrol, Austria: an open-label, observational phase 4 trial
Lancet Microbe. 2023 Jun 21:S2666-5247(23)00107-6. doi: 10.1016/S2666-5247(23)00107-6. Online ahead of print.ABSTRACTBACKGROUND: Correlates of protection could help to assess the extent to which a person is protected from SARS-CoV-2 infection after vaccination (so-called breakthrough infection). We aimed to clarify associations of antibody and T-cell responses after vaccination against COVID-19 with risk of a SARS-CoV-2 breakthrough infection and whether measurement of these responses enhances risk prediction.METHODS: We did an open-label, phase 4 trial in two community centres in the Schwaz district of the Federal State o...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Lisa Seekircher Zolt án Bánki Janine Kimpel Annika R össler Helena Sch äfer Barbara Falkensammer David Bante Lukas Forer Sebastian Sch önherr Shieldvacc-2 Study Group Teresa Harthaller Magdalena Sacher Cornelia Ower Lena Tschiderer Hanno Ulmer Floria Source Type: research

Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8 < sup > + < /sup > T cells in HIV infection
EBioMedicine. 2023 Apr 12;91:104557. doi: 10.1016/j.ebiom.2023.104557. Online ahead of print.ABSTRACTBACKGROUND: CD8+ T cells equipped with a full arsenal of antiviral effector functions are critical for effective immune control of HIV-1. It has nonetheless remained unclear how best to elicit such potent cellular immune responses in the context of immunotherapy or vaccination. HIV-2 has been associated with milder disease manifestations and more commonly elicits functionally replete virus-specific CD8+ T cell responses compared with HIV-1. We aimed to learn from this immunological dichotomy and to develop informed strategi...
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Mariela P Cabral-Piccin Laura Papagno Xavier Lahaye Federico Perdomo-Celis Stevenn Volant Eoghann White Val érie Monceaux Sian Llewellyn-Lacey R émi Fromentin David A Price Nicolas Chomont Nicolas Manel Asier Saez-Cirion Victor Appay Source Type: research

Nationwide introduction of HPV vaccine in Zimbabwe 2018-2019: Experiences with multiple cohort vaccination delivery
PLOS Glob Public Health. 2022 Apr 6;2(4):e0000101. doi: 10.1371/journal.pgph.0000101. eCollection 2022.ABSTRACTThe World Health Organization (WHO) recommends the human papillomavirus (HPV) vaccine for girls aged 9-14 years for cervical cancer prevention and encourages vaccinating multiple cohorts in the first year to maximize impact. The HPV vaccine was introduced nationwide in Zimbabwe in 2018 through a 1-week school-based campaign to multiple cohorts (all girls 10-14 years old), followed by a single cohort (grade 5 girls in school and age 10 girls out-of-school) in 2019. During the 2019 campaign, the multiple cohort's se...
Source: Cancer Control - March 24, 2023 Category: Cancer & Oncology Authors: Julie Garon Carlton Joan Marembo Portia Manangazira Maxwell Rupfutse Adelaide Shearley Egnes Makwabarara Anna Hidle Anagha Loharikar Source Type: research

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Implementing behavioural science informed letter interventions to increase COVID-19 vaccination uptake in uncontactable London residents: a difference-in-difference study in London, UK
This study evaluated the impact of behavioural science-informed (BI) letters on vaccination uptake.METHODS: Unvaccinated residents of the Central London CCG who were deemed uncontactable (through text messaging and phone calls) were identified with the whole systems integrated care database. BI letters were sent to residents in the intervention CCG between May and June, 2021. Three neighbouring CCGs in London with similar non-responder data were used as control groups. A linear difference-in-difference analysis was undertaken to assess change in vaccine uptake rate across all four CCGs. Percentage point change was adjusted...
Source: Cancer Control - March 17, 2023 Category: Cancer & Oncology Authors: Sarah W Huf Lena Woldmann Roberto Fernandez Crespo Kate Grailey Bahram Hassanpourfard Matthew Chisambi Kirstie Black Joe Nguyen Bob Klaber Ara Darzi Source Type: research

A research and development (R & amp;D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy
This report summarizes the major issues and areas of research outlined in the CVR and identifies high-priority milestones. The CVR covers a 6-year timeframe and is organized into five topic areas: virology, immunology, vaccinology, animal and human infection models, and policy and finance. Included in each topic area are key barriers, gaps, strategic goals, milestones, and additional R&D priorities. The roadmap includes 20 goals and 86 R&D milestones, 26 of which are ranked as high priority. By identifying key issues, and milestones for addressing them, the CVR provides a framework to guide funding and research cam...
Source: Cancer Control - March 4, 2023 Category: Cancer & Oncology Authors: Kristine A Moore Tabitha Leighton Julia T Ostrowsky Cory J Anderson Richard N Danila Angela K Ulrich Eve M Lackritz Angela J Mehr Ralph S Baric Norman W Baylor Bruce G Gellin Jennifer L Gordon Florian Krammer Stanley Perlman Helen V Rees Melanie Saville C Source Type: research

Breakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium
This study was partly supported by grants from the National Cancer Institute grant number P30 CA068485 to C-YH, YS, SM, JLW; T32-CA236621 and P30-CA046592 to C.R.F; CTSA 2UL1TR001425-05A1 to TMW-D; ACS/FHI Real-World Data Impact Award, P50 MD017341-01, R21 CA242044-01A1, Susan G. Komen Leadership Grant Hunt to MKA. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/NIH).PMID:36818595 | PMC:PMC9925160 | DOI:10.1016/j.lana.2023.100445
Source: Cancer Control - February 23, 2023 Category: Cancer & Oncology Authors: Toni K Choueiri Chris Labaki Ziad Bakouny Chih-Yuan Hsu Andrew L Schmidt Gilberto de Lima Lopes Clara Hwang Sunny R K Singh Chinmay Jani Lisa B Weissmann Elizabeth A Griffiths Susan Halabi Ulysses Wu Stephanie Berg Timothy E O'Connor Trisha M Wise-Draper Source Type: research

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

End of year message from Cochrane ' s CEO, Catherine Spencer
Dear Cochrane Colleagues, Members and Supporters, Thank you to everyone across our community for your dedication and commitment to Cochrane during 2022. The last few years have at times felt tumultuous, both due to Covid and world events, but also because of the changes we are making to ensure that Cochrane is fit for a future that meets our vision of aworld of better health for all people, where decisions about health and care are informed by high-quality evidence. We are well on our way to creating an evolved impact-driven organisation to support evidence-based health and social care. With your help we are building on ...
Source: Cochrane News and Events - December 20, 2022 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Implementing behavioural science informed letter interventions to increase COVID-19 vaccination uptake in uncontactable London residents: a difference-in-difference study in London, UK
This study evaluated the impact of behavioural science-informed (BI) letters on vaccination uptake.METHODS: Unvaccinated residents of the Central London CCG who were deemed uncontactable (through text messaging and phone calls) were identified with the whole systems integrated care database. BI letters were sent to residents in the intervention CCG between May and June, 2021. Three neighbouring CCGs in London with similar non-responder data were used as control groups. A linear difference-in-difference analysis was undertaken to assess change in vaccine uptake rate across all four CCGs. Percentage point change was adjusted...
Source: Cancer Control - November 30, 2022 Category: Cancer & Oncology Authors: Sarah W Huf Lena Woldmann Roberto Fernandez Crespo Kate Grailey Bahram Hassanpourfard Matthew Chisambi Kirstie Black Joe Nguyen Bob Klaber Ara Darzi Source Type: research

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