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Total 62 results found since Jan 2013.

Biotechnology in India - An Analysis of Biotechnology Industry Research Assistance Council (BIRAC)-Supported Projects
Chembiochem. 2023 Sep 5:e202300302. doi: 10.1002/cbic.202300302. Online ahead of print.ABSTRACTA comprehensive analysis of 2.165 projects funded by India's Department of Biotechnology since 2005 through private-public partnerships, and as of 2012 through the 'Biotechnology Industry Research Assistance Council (BIRAC)' until BIRAC's tenth anniversary end of March 2022 reveals details of the science and technology underpinning past and current biotechnology research and development projects in the country. They are led by human healthcare projects (74,9% overall), of which medical technology (58,7%) and therapeutics (24,5%) ...
Source: Chembiochem - September 5, 2023 Category: Biochemistry Authors: Edmond Differding Source Type: research

Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A research and development (R & amp;D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy
This report summarizes the major issues and areas of research outlined in the CVR and identifies high-priority milestones. The CVR covers a 6-year timeframe and is organized into five topic areas: virology, immunology, vaccinology, animal and human infection models, and policy and finance. Included in each topic area are key barriers, gaps, strategic goals, milestones, and additional R&D priorities. The roadmap includes 20 goals and 86 R&D milestones, 26 of which are ranked as high priority. By identifying key issues, and milestones for addressing them, the CVR provides a framework to guide funding and research cam...
Source: Vaccine - March 4, 2023 Category: Allergy & Immunology Authors: Kristine A Moore Tabitha Leighton Julia T Ostrowsky Cory J Anderson Richard N Danila Angela K Ulrich Eve M Lackritz Angela J Mehr Ralph S Baric Norman W Baylor Bruce G Gellin Jennifer L Gordon Florian Krammer Stanley Perlman Helen V Rees Melanie Saville C Source Type: research

News at a glance: Science moonshot, UC student strike, and an x-ray boost
LUNAR SCIENCE Science probes head for Moon orbit After years of delay, NASA’s Space Launch System (SLS) rocketed toward the Moon last week, and data indicate its scientific payloads are working as planned. The rocket is the agency’s most powerful since the Apollo-era Saturn V, and the launch marks the first orbital flight on a NASA rocket since the retirement of the Space Shuttle in 2011. The uncrewed mission, which will take the Orion capsule on a 26-day journey past the Moon and back, is the first in Artemis, NASA’s plan to return astronauts to the surface of the Moon by 2025. At an estimated $4 bill...
Source: Science of Aging Knowledge Environment - November 22, 2022 Category: Geriatrics Source Type: research

Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The battle against malaria in Africa has stalled. Can research in Mozambique explain why?
.news-article__hero--featured .parallax__element{ object-position: 45% 50%; -o-object-position: 45% 50%; } .news-article__figure.inset { float: right !important; width: 33%; margin: 0.5rem 0 0.5rem 1rem; } @media (min-width: 576px) { .news-article__figure.inset { width: 25%; margin: 0.5rem 0 0.5rem 2rem; } } @media (min-width: 768px) { .news-article__figure.inset { width: 40%; margin: 0.5rem 0 0.5rem 1rem; } } Moisés Mapanga, a burly man of 49, is the bait. At 6 p.m. on a mid-April evening, he climbs into an orange tent outside his one-room house in Matutuíne, a hot, swampy district near Maputo, the cap...
Source: Science of Aging Knowledge Environment - September 8, 2022 Category: Geriatrics Source Type: research

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
August 04, 2022 Edition-----The war seems to grind on sadly and Pres. Biden is having a second round with COVID as unprecedented weather happens all over the US. It all feels rather like ‘the end of days’!In the UK we see an increasing chance of a third female PM being elected as the country seems to be struggling. We do need to remember however the UK remains a significant power with nuclear weapons and home-grown nuclear submarines!In OZ we have had last week working out how to progress the First Nations ‘Voice’ as we wrap up the 1st session of Parliament for the new Government. Comments welcome on how you think ...
Source: Australian Health Information Technology - August 4, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

News at a glance: Webb telescope dinged, U.S.-Russia research paused, and NASA ’s UFO study
Table of contents A version of this story appeared in Science, Vol 376, Issue 6599. Download PDF ASTRONOMY Star mapper provides Milky Way portrait he European Space Agency’s Gaia satellite has now mapped almost 2 billion of the Milky Way’s stars, logging their positions, speeds, temperatures, and other parameters—and allowing astronomers to chart the Galaxy’s structure and evolution. Last week, operators released the third major trove of data, including lists of 800,000 binary stars, 10 million variable stars, and, within the Solar System, 156,000...
Source: Science of Aging Knowledge Environment - June 16, 2022 Category: Geriatrics Source Type: research

A gaps-and-needs analysis of vaccine R & amp;D in Europe: Recommendations to improve the research infrastructure
Biologicals. 2022 Feb 26:S1045-1056(22)00017-3. doi: 10.1016/j.biologicals.2022.02.003. Online ahead of print.ABSTRACTThe COVID-19 pandemic has brought into sharp focus the importance of strategies supporting vaccine development. During the pandemic, TRANSVAC, the European vaccine-research-infrastructure initiative, undertook an in-depth consultation of stakeholders to identify how best to position and sustain a European vaccine R&D infrastructure. The consultation included an online survey incorporating a gaps-and-needs analysis, follow-up interviews and focus-group meetings. Between October 2020 and June 2021, 53 org...
Source: Biologicals : Journal of the International Association of Biological Standardization - March 2, 2022 Category: Biotechnology Authors: Stefan Jungbluth Hilde Depraetere Monika Slezak Dennis Christensen Norbert Stockhofe Laurent Beloeil Source Type: research