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Evidence suggests pandemic came from nature, not a lab, panel says
The acrimonious debate over the origins of the COVID-19 pandemic flared up again this week with a report from an expert panel concluding that SARS-CoV-2 likely spread naturally in a zoonotic jump from an animal to humans—without help from a lab. “Our paper recognizes that there are different possible origins, but the evidence towards zoonosis is overwhelming,” says co-author Danielle Anderson, a virologist at the University of Melbourne. The report, which includes an analysis that found the peer-reviewed literature overwhelmingly supports the zoonotic hypotheses, appeared in the Proceedings of the Nationa...
Source: ScienceNOW - October 10, 2022 Category: Science Source Type: news

Ketogenic Diets for Diabetes and Obesity
To the Editors Although Joshi and colleagues ’ Viewpoint on ketogenic diets for diabetes and obesity makes an important point that enthusiasm for these diets has outstripped evidence, I have 2 concerns. First, the authors fail to call for high-quality research to address this enthusiasm gap. Some of the hype has occurred because there is evi dence that these diets can improve glycemic control in diabetes for a sustained period of time. Our own clinical trial showed statistically (and clinically) significant improvements in glycated hemoglobin levels at 12 months. We recognize, however, that larger trials with longer foll...
Source: JAMA Internal Medicine - December 1, 2019 Category: Internal Medicine Source Type: research

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

Techniques for Studying Decoding of Single Cell Dynamics
Stevan Jeknić1,2†, Takamasa Kudo2,3† and Markus W. Covert1,2,3* 1Department of Bioengineering, Stanford University, Stanford, CA, United States 2Allen Discovery Center for Systems Modeling of Infection, Stanford, CA, United States 3Department of Chemical and Systems Biology, Stanford University, Stanford, CA, United States Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The ...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Can Liver and Diet Impact Alzheimer's Risk?
This research has a variety of interesting implications. For example, it highlights a potential relationship between conditions such as obesity and diabetes and Alzheimer ’s.ByAlzheimer's Reading RoomReduced levels of plasmalogens — a class of lipids created in the liver that are integral to cell membranes in the brain—are associated with an increased risk of Alzheimer ’s Disease, according to new research.Plasmalogens are created in the liver and are dispersed through the blood stream in the form of lipoproteins, which also transport cholesterol and other lipids to and from cells and tissues throughout the body, i...
Source: Alzheimer's Reading Room, The - July 31, 2018 Category: Neurology Tags: alzheimer's risk alzheimers research diabetes diet health lifestyle liver obesity science Source Type: blogs

Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions! Spotlight New Membership certificates are arriving soon! To receive a new certificate, you must verify that your organization’s record is up-to-date. Check out our Membership renewal flyer for more information about NNLM Membership, and instructions on how to complete the renewal process. NIHSeniorHealth is retiring on August 1. Looking for quality alternatives? Check out our recent posting on the MARquee to learn about other NLM and NIH health resources for older adults. National Network of Libraries of Medicine News Ongoing: NNLM...
Source: NN/LM Middle Atlantic Region Blog - July 14, 2017 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news