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Determination of cefuroxime in breast milk by LC-MS/MS using SALLME technique
In this study, we aimed to develop the LC-MS/MS method using salt-assisted liquid-liquid micro-extraction (SALLME) for the determination of cefuroxime in breast milk. The method was validated according to the European Medicines Agency (EMA) guidelines. Cefuroxime and the internal standard cefixime were extracted from plasma by a SALLME technique. The results obtained from the entire validation study are at an acceptable level according to the EMA criteria. The calibration curve of cefuroxime was between 25 and 1000 ng/ml, with correlation coefficients of >0.99. The lower limit of quantitation was 25 ng/ml for cefuroxime...
Source: Biomedical Chromatography : BMC - September 12, 2023 Category: Biomedical Science Authors: Aykut Kul Olcay Sagirli Source Type: research

Sodium content targets for pre-packaged foods, China: a quantitative study and proposal
CONCLUSION: This study provides the scientific rationale for government policy on setting targets for food sodium content in China. Simultaneous action on discretionary salt use should also be taken.PMID:37397173 | PMC:PMC10300770 | DOI:10.2471/BLT.23.289992
Source: Bulletin of the World Health Organization - July 3, 2023 Category: International Medicine & Public Health Authors: Puhong Zhang Jiguo Zhang Yuan Li Le Dong Feng J He Mhairi Brown Simone Pettigrew Jacqui Webster Rain Yamamoto Chizuru Nishida Aidong Liu Xiaoguang Yang Bing Zhang Gangqiang Ding Huijun Wang Source Type: research

Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
Br J Nutr. 2023 Mar 13:1-43. doi: 10.1017/S000711452300051X. Online ahead of print.ABSTRACTVegan and vegetarian diets are widely supported and adopted, but individuals following such diets remain at greater risk of iodine deficiency. This systematic review and meta-analysis was conducted to assess the iodine intake and status in adults following a vegan or vegetarian diet in the modern day. A systematic review and quality assessment were conducted from October 2020-December 2022 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analysis of Observational Studies in Epidemiolog...
Source: The British Journal of Nutrition - March 13, 2023 Category: Nutrition Authors: Elizabeth Eveleigh Lisa Coneyworth Simon Welham Source Type: research

Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis
CONCLUSIONS: There is currently insufficient evidence to determine the effect of ataluren as a therapy for people with CF with class I mutations. One trial reported favourable results for ataluren in a post hoc subgroup analysis of participants not receiving chronic inhaled aminoglycosides, but these were not reproduced in the later trial, suggesting that the earlier results may have occurred by chance. Future trials should carefully assess for adverse events, notably renal impairment, and consider the possibility of drug interactions. Cross-over trials should be avoided, given the potential for the treatment to change the...
Source: Cochrane Database of Systematic Reviews - March 3, 2023 Category: General Medicine Authors: Aisha A Aslam Ian P Sinha Kevin W Southern Source Type: research

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