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Application of an artificial intelligence-based tool in < sup > 18 < /sup > FFDG PET/CT for the assessment of bone marrow involvement in multiple myeloma
CONCLUSIONS: The automated, volumetric, whole-body PET/CT assessment of the BM metabolic activity in MM is feasible with the herein applied method and correlates with clinically relevant parameters in the disease. This methodology offers a potentially reliable tool in the direction of optimization and standardization of PET/CT interpretation in MM. Based on the present promising findings, the deep learning-based approach will be further evaluated in future prospective studies with larger patient cohorts.PMID:37493665 | DOI:10.1007/s00259-023-06339-5
Source: Molecular Medicine - July 26, 2023 Category: Molecular Biology Authors: Christos Sachpekidis Olof Enqvist Johannes Ul én Annette Kopp-Schneider Leyun Pan Anna Jauch Marina Hajiyianni Lukas John Niels Weinhold Sandra Sauer Hartmut Goldschmidt Lars Edenbrandt Antonia Dimitrakopoulou-Strauss Source Type: research

Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting. Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evaluation of Psychosocial Outcomes of Living Liver Donors in Liver Transplantation
CONCLUSION: The study revealed that gender, marital status, employment status, and education levels were associated with psychosocial outcomes. The financial status was the main factor affecting each psychosocial variable. Financial status needs to be assessed in detail before and after the operation.PMID:35550542 | DOI:10.5152/tjg.2022.21262
Source: The Turkish Journal of Gastroenterology - May 13, 2022 Category: Gastroenterology Authors: Yaprak Sar ıgöl Ordin Arzu Kader Harmanc ı Seren Özgül Karayurt G ülay Aksu Kul Murat K ılıç Cemal Ata Bozoklar Yaman Tokat Source Type: research

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