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Vaccination: Veterinary Vaccinations
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Total 16 results found since Jan 2013.
An Advax-CpG55.2 ™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge
Vaccine. 2023 Jun 19:S0264-410X(23)00748-X. doi: 10.1016/j.vaccine.2023.06.063. Online ahead of print.ABSTRACTTraditional protein-based vaccine approaches to COVID-19 were overshadowed by the new mRNA and adenoviral vector vaccine approaches which were first to receive marketing authorization. The current study tested for the first time in repurposed aged (median 15.4 years) cynomolgus macaques, a novel Advax-CpG55.2™ adjuvanted recombinant extracellular domain spike protein trimer antigen for immunogenicity, protection and safety. Nine animals received two intramuscular injections 10 days apart of recombinant spike prot...
Source: Vaccine - June 24, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo Lei Li Greiciely Andr é King Ho Leong Elizabeth W Howerth Anne G Bebin-Blackwell Ted M Ross Nikolai Petrovsky Source Type: research
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
August 04, 2022 Edition-----The war seems to grind on sadly and Pres. Biden is having a second round with COVID as unprecedented weather happens all over the US. It all feels rather like ‘the end of days’!In the UK we see an increasing chance of a third female PM being elected as the country seems to be struggling. We do need to remember however the UK remains a significant power with nuclear weapons and home-grown nuclear submarines!In OZ we have had last week working out how to progress the First Nations ‘Voice’ as we wrap up the 1st session of Parliament for the new Government. Comments welcome on how you think ...
Source: Australian Health Information Technology - August 4, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
The contribution of field efficacy studies to the evaluation of applications for veterinary vaccines evaluated through the European Union centralised authorisation procedure
Biologicals. 2021 Apr 8:S1045-1056(21)00024-5. doi: 10.1016/j.biologicals.2021.03.001. Online ahead of print.ABSTRACTTo examine the contribution that field efficacy studies made to the assessment of marketing authorisation (MA) applications, a retrospective analysis was conducted for 100 veterinary vaccines that had been evaluated by the European Medicines Agency (EMA) between 1996 and 2017. For 52 veterinary vaccines, scrutiny of the European Public Assessment Report (EPAR) and/or the summary of product characteristics (SPC) identified objective evidence that field efficacy studies made an important or substantial impact ...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 12, 2021 Category: Biotechnology Authors: David Mackay Cristina Martin Jimenez Faye Ioannou Martin Ilott Source Type: research
Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00384-4. doi: 10.1016/j.vaccine.2021.03.078. Online ahead of print.ABSTRACTFor batch release of legacy vaccines such as DTaP, in vivo potency release assays are required. We quantified the variability of in vivo potency release assays for four DTaP (Diphtheria, Tetanus, acellular Pertussis) products of different manufacturers. With their large CV (Coefficients of Variance) ranging from 16% to 132%, these in vivo assays are of limited value to ensure their potency is consistent and similar to the clinical batches used for the marketing authorisation. Our data show that, although individual ...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Coen A L Stalpers Irene A Retmana Jeroen L A Pennings Rob J Vandebriel Coenraad F M Hendriksen Arnoud M Akkermans Marcel H N Hoefnagel Source Type: research
Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit.
Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Revisiting A & P Learning Outcomes | Episode 54
Host Kevin Patton previews the newly revised HAPS Learning Outcomes for A&P, discussing the goals of the revision and samples a few of the changes. Why is noon a good time to get your flu shot? Are there neurons that actively erase memories? Vaping: why A&P teachers need to keep up with the news.00:42 | Timing of Vaccinations02:36 | Sponsored by HAPS03:04 | Neurons That Erase Memory08:22 | Sponsored by AAA08:47 | Vaping13:45 | Sponsored by HAPI Online Graduate Program14:28 | Revisiting the HAPS Learning Outcomes for A&P41:43 | Staying ConnectedIf you cannot see or activate the audio pla...
Source: The A and P Professor - October 20, 2019 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Mysterious Company Claims to Sell Sneeze-Filled Tissues for $80. Is It Real?
The package appeared one day, unbidden, on the desk of a TIME writer. Inside was a slick white box that housed a petri dish sealed with gold tape. In the dish was a crumpled tissue—and inside the tissue were, allegedly, the germs of a sick person who had sneezed into it.
Vaev Tissue, the only product of a new startup based in Los Angeles, costs $79.99, according to the company’s website. Its sole purpose is to give the user a cold virus. “We believe using a tissue that carries a human sneeze is safer than needles or pills,” read the note that came with the product, written by the founder of the comp...
Source: TIME: Health - January 18, 2019 Category: Consumer Health News Authors: Mandy Oaklander Tags: Uncategorized public health Source Type: news
Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
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Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
