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Disproportionality analysis of reported drug adverse events to assess a potential safety signal for pentavalent vaccine in 2019 in El Salvador
Vaccine. 2021 Jul 15:S0264-410X(21)00869-0. doi: 10.1016/j.vaccine.2021.07.010. Online ahead of print.ABSTRACTDetection and surveillance of vaccine safety hazards is a public health staple. In the post-marketing phase, when vaccines are used in mass, it is crucial to monitor potential signals of adverse reactions that may have been missed in the pre-marketing phase. We analysed spontaneous reports of drug adverse events in El Salvador to assess a potential safety signal related to an increase in febrile seizures following the pentavalent (diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae Type B) vacci...
Source: Vaccine - July 19, 2021 Category: Allergy & Immunology Authors: Miguel Elas Nora Villatoro Lorenzo Pezzoli Source Type: research

Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00384-4. doi: 10.1016/j.vaccine.2021.03.078. Online ahead of print.ABSTRACTFor batch release of legacy vaccines such as DTaP, in vivo potency release assays are required. We quantified the variability of in vivo potency release assays for four DTaP (Diphtheria, Tetanus, acellular Pertussis) products of different manufacturers. With their large CV (Coefficients of Variance) ranging from 16% to 132%, these in vivo assays are of limited value to ensure their potency is consistent and similar to the clinical batches used for the marketing authorisation. Our data show that, although individual ...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Coen A L Stalpers Irene A Retmana Jeroen L A Pennings Rob J Vandebriel Coenraad F M Hendriksen Arnoud M Akkermans Marcel H N Hoefnagel Source Type: research

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Review of vaccination in pregnancy to prevent pertussis in early infancy.
Abstract Maternal pertussis vaccination has been introduced in several countries to protect infants from birth until routine infant vaccination takes place. This review assesses existing evidence on the effectiveness and safety of immunization in pregnancy. The search was finalized in April 2017 and was based on searches using several databases. The selection criteria included any experimental or observational study reporting on the immunogenicity, effectiveness or safety of vaccination with a pertussis-containing vaccine in pregnant women and their infants. Following de-duplication and exclusions, we identified 8...
Source: Journal of Medical Microbiology - September 17, 2018 Category: Microbiology Authors: Campbell H, Gupta S, Dolan GP, Kapadia SJ, Kumar Singh A, Andrews N, Amirthalingam G Tags: J Med Microbiol Source Type: research

Diversity of Secretion Systems Associated with Virulence Characteristics of the Classical Bordetellae.
Abstract Secretion systems are key virulence factors, modulating interactions between pathogens and host's immune response. Six potential secretion systems (T1SS-T6SS) have been discussed in classical bordetellae, respiratory commensals/pathogens of mammals. The prototypical Bordetella bronchiseptica strain RB50 genome seems to contain all six, while two human-restricted subspecies, B. parapertussis and B. pertussis, have lost different subsets of these. This implicates secretion systems in the divergent evolutionary histories that have led to their success in different niches. Based on our prior work demonstratin...
Source: Microbiology - October 9, 2015 Category: Microbiology Authors: Park J, Zhang Y, Chen C, Dudley EG, Harvill ET Tags: Microbiology Source Type: research