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A quality improvement study: Optimizing pneumococcal vaccination rates in children with cochlear implants
This study aimed to examine the pneumococcal immunization status and rate of invasive pneumococcal disease in children with cochlear implants at a tertiary paediatric hospital over a 12-year period. Additionally, the impacts of vaccination reminders and a dedicated immunization clinic on pneumococcal vaccination rates were assessed. This quality improvement study included 200 children who had received a cochlear implant through the Children's Hearing Implant Program at a tertiary paediatric hospital servicing the state of Western Australia. The majority of children (88%) were not up to date with additionally recommended pn...
Source: Vaccine - June 19, 2022 Category: Allergy & Immunology Authors: S Tay A C Bowen C C Blyth P Clifford R Clack T Ford H Herbert J Kuthubutheen F Mascaro A O'Mahoney S Rodrigues T Tran A J Campbell Source Type: research

Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study
This study is registered with ClinicalTrials.gov, NCT04089436, and is now complete.FINDINGS: Between July 28, 2014, and Dec 31, 2017, 664 children with encephalitis were enrolled. Median age was 4·3 years (1·8-8·8), 295 (44%) children were female, and 369 (56%) were male. A confirmed or probable cause of encephalitis was identified in 425 (64%) patients: 216 (33%) of 664 cases were due to Japanese encephalitis virus, 27 (4%) were due to dengue virus, 26 (4%) were due to influenza virus, 24 (4%) were due to herpes simplex virus 1, 18 (3%) were due to Mycobacterium tuberculosis, 17 (3%) were due to Streptococcus pneumonia...
Source: Herpes - June 17, 2022 Category: Infectious Diseases Authors: Jean David Pommier Chris Gorman Yoann Crabol Kevin Bleakley Heng Sothy Ky Santy Huong Thi Thu Tran Lam Van Nguyen Em Bunnakea Chaw Su Hlaing Aye Mya Min Aye Julien Cappelle Magali Herrant Patrice Piola Bruno Rosset Veronique Chevalier Arnaud Tarantola Mey Source Type: research

A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
We report a case of Bordetella bronchiseptica pneumonia in a 67-year-old immunocompromised host. His past medical history included multiple myeloma treated with autologous bone marrow transplant followed by a chimeric antigen receptor cell therapy for relapse. He was admitted with unrelenting diarrhea due to HHV-6 pancolitis. During the hospital course he developed high-grade fever (102.3°F), cough and respiratory failure requiring mechanical ventilation. Chest imaging demonstrated bilateral opacities most pronounced at lung bases and worsening mediastinal lymphadenopathy. Bronchoalveolar lavage cultures grew Bordetella b...
Source: Respiratory Care - June 2, 2022 Category: Respiratory Medicine Authors: Lipisha Agarwal Harpreet Singh Chinmay Jani Peymaan Banankhah Mohammed Abdalla Jonathan S Kurman Rose A Franco Source Type: research

Post immunization COVID-19 disease
J Family Med Prim Care. 2022 Apr;11(4):1555-1557. doi: 10.4103/jfmpc.jfmpc_1975_21. Epub 2022 Mar 18.ABSTRACTOne hundred and two patients reported to peripheral hospital, of these 73 (77%) and 23 (95%) suffered from COVID-19 disease, were immunized as per availability of Covishield 78 (77%) and Covaxin 24 (23%), respectively. Of these, three died (3%). Inflammatory markers were raised in Covishield vs. Covaxin 26 (36%) vs. 7 (31%), 46 (63%) vs. 8 (35%), 57 (78%) vs. 14 (61%), 29 (40%) vs. (73%), C-reactive proteins and serum ferritin, and positive for COVID-19 antigen and RTPCR and COVID-19 pneumonia, respectively. Irrespe...
Source: Primary Care - May 6, 2022 Category: Primary Care Authors: Himmatrao S Bawaskar Pramodini H Bawaskar Source Type: research

Effectiveness of adenovirus type 5 vectored and inactivated COVID-19 vaccines against symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the B.1.617.2 (Delta) variant: Evidence from an outbreak in Yunnan, China, 2021
Vaccine. 2022 Apr 1:S0264-410X(22)00386-3. doi: 10.1016/j.vaccine.2022.03.067. Online ahead of print.ABSTRACTBACKGROUND: In partial response to the coronavirus disease 2019 (COVID-19) pandemic, countries around the world are conducting large-scale vaccination campaigns. Real-world estimates of vaccine effectiveness (VE) against the B.1.617.2 (Delta) variant are still limited. An outbreak in Ruili city of Chinaprovided an opportunity to evaluate VE against the Delta variant of two types of COVID-19 vaccines in use in China and globally - inactivated (CoronaVac and BBIBP-CorV) and adenovirus type 5 vectored (Convidecia) vacc...
Source: Vaccine - April 11, 2022 Category: Allergy & Immunology Authors: Chao Ma Weiwei Sun Tingting Tang Manhong Jia Yonghua Liu Yongfang Wan Jizhou Han Lance Rodewald Junhong Li Yudan Song Yamin Wang Dan Wu Fuzhen Wang Hui Zheng Lin Tang George F Gao Zundong Yin Zhijie An Source Type: research

Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study
Vaccine. 2022 Mar 26:S0264-410X(22)00359-0. doi: 10.1016/j.vaccine.2022.03.048. Online ahead of print.ABSTRACTWe used an indirect cohort analysis in children under 5 years-old from 2002 to 2018 to examine vaccine effectiveness (VE) of the 7-valent pneumococcal conjugate vaccine (PCV) (3 + 1 doses in most regions) and the 13-valent PCV (2 + 1 doses in all regions) against invasive pneumococcal disease (IPD) caused by vaccine serotypes in children in Canada. Cases were identified from the Canadian Immunization Monitoring Program ACTive (IMPACT), a national active surveillance network of 12 tertiary care pediatric hospitals t...
Source: Vaccine - March 30, 2022 Category: Allergy & Immunology Authors: Leah J Ricketson Julie A Bettinger Manish Sadarangani Scott A Halperin James D Kellner Canadian Immunization Monitoring Program, Active (IMPACT) Investigators Source Type: research

Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Therapeutic potential of highly diluted antibodies in antibiotic-resistant infection
Eur J Pharm Sci. 2022 Mar 3:106161. doi: 10.1016/j.ejps.2022.106161. Online ahead of print.ABSTRACTKlebsiella pneumoniae is one of the main causes of hospital-acquired infections. Its rate of antimicrobial resistance is rapidly increasing, while there are no licensed human vaccines against it. A novel therapeutic approach involves modulation of the host immune response combined with antibiotic treatment. One of the approaches to immunomodulation can be the use of antibodies (Abs) in a specific technological form of high dilutions (hd). The aim of the study was to assess whether hd-Abs could affect the antibacterial activit...
Source: European Journal of Pharmaceutical Sciences - March 6, 2022 Category: Drugs & Pharmacology Authors: Alexandra G Emelianova Natalia V Petrova Christophe Fremez Maxime Fontani é Sergey А Tarasov Оleg I Epstein Source Type: research

New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses
Semin Respir Crit Care Med. 2022 Jan 18. doi: 10.1055/s-0041-1740582. Online ahead of print.ABSTRACTA fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission and hospital-based clusters. Data from before the pandemic suggest the same can be true of influenza, respiratory syncytial virus, and other respiratory viruses. The pandemic has also helped clarify the primary mechanisms and risk factors for viral transmission. Respiratory vi...
Source: Respiratory Care - January 18, 2022 Category: Respiratory Medicine Authors: Michael Klompas Source Type: research

Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study
Lancet Reg Health West Pac. 2022 Jan 3;20:100361. doi: 10.1016/j.lanwpc.2021.100361. eCollection 2022 Mar.ABSTRACTBACKGROUND: Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.METHODS: Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.FINDINGS: Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 pat...
Source: Herpes - January 17, 2022 Category: Infectious Diseases Authors: Li-Ping Wang Yang Yuan Ying-Le Liu Qing-Bin Lu Lu-Sha Shi Xiang Ren Shi-Xia Zhou Hai-Yang Zhang Xiao-Ai Zhang Xin Wang Yi-Fei Wang Sheng-Hong Lin Cui-Hong Zhang Meng-Jie Geng Jun Li Shi-Wen Zhao Zhi-Gang Yi Xiao Chen Zuo-Sen Yang Lei Meng Xin-Hua Wang Ai- Source Type: research

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