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ABO blood type correlates with risk and protective factors for chronic suppurative otitis media
CONCLUSIONS AND SIGNIFICANCE: Our study identified the risk and protective factors for CSOM among different blood types. The findings might provide new insights into taking precautions against CSOM in people of different blood types.PMID:37702578 | DOI:10.1080/00016489.2023.2252031
Source: Acta Oto-Laryngologica - September 13, 2023 Category: ENT & OMF Authors: Junli Wang Bin Chen Ying Gao Juan Hu Zichen Chen Yan Zhang Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
ABO blood type correlates with risk and protective factors for chronic suppurative otitis media
CONCLUSIONS AND SIGNIFICANCE: Our study identified the risk and protective factors for CSOM among different blood types. The findings might provide new insights into taking precautions against CSOM in people of different blood types.PMID:37702578 | DOI:10.1080/00016489.2023.2252031
Source: Acta Oto-Laryngologica - September 13, 2023 Category: ENT & OMF Authors: Junli Wang Bin Chen Ying Gao Juan Hu Zichen Chen Yan Zhang Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
ABO blood type correlates with risk and protective factors for chronic suppurative otitis media
CONCLUSIONS AND SIGNIFICANCE: Our study identified the risk and protective factors for CSOM among different blood types. The findings might provide new insights into taking precautions against CSOM in people of different blood types.PMID:37702578 | DOI:10.1080/00016489.2023.2252031
Source: Acta Oto-Laryngologica - September 13, 2023 Category: ENT & OMF Authors: Junli Wang Bin Chen Ying Gao Juan Hu Zichen Chen Yan Zhang Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
ABO blood type correlates with risk and protective factors for chronic suppurative otitis media
CONCLUSIONS AND SIGNIFICANCE: Our study identified the risk and protective factors for CSOM among different blood types. The findings might provide new insights into taking precautions against CSOM in people of different blood types.PMID:37702578 | DOI:10.1080/00016489.2023.2252031
Source: Acta Oto-Laryngologica - September 13, 2023 Category: ENT & OMF Authors: Junli Wang Bin Chen Ying Gao Juan Hu Zichen Chen Yan Zhang Source Type: research
Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
