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Successful endovascular repair of an unusual right-to-left shunt presenting with cerebral ischemia
We report a 54-year-old man with a stroke due to a unique right-to-left shunt who underwent successful endovascular treatment. This patient developed acute onset of right arm weakness with facial droop and aphasia which improved after intravenous thrombolysis. An MRI showed acute cerebral ischemia in the left middle cerebral artery and left posterior cerebral artery distribution. The patient developed recurrent stroke symptoms during agitated saline injection while undergoing a transthoracic echocardiogram which showed right-to-left shunting. Chest CT scan and conventional angiography revealed near occlusion of the superio...
Source: Journal of Clinical Neuroscience - November 3, 2014 Category: Neuroscience Source Type: research

Electrical Stimulation of Cerebellar Fastigial Nucleus: Mechanism of Neuroprotection and Prospects for Clinical Application against Cerebral Ischemia.
Abstract For around two decades, electrical fastigial nucleus stimulation (FNS) has been demonstrated to induce neuroprotection involving multiple mechanisms. In this review, we summarize the protective effects of FNS against cerebral ischemia through the inhibition of electrical activity around the lesion, excitotoxic damage on neurons, and brain inflammatory response, as well as apoptosis. Moreover, FNS has been reported to promote nerve tissue repair, reconstruction, and neurological rehabilitation and improve stroke-related complications including poststroke cognitive dysfunction, depression, and abnormal hear...
Source: CNS Neuroscience and Therapeutics - June 16, 2014 Category: Neuroscience Authors: Wang J, Dong WW, Zhang WH, Zheng J, Wang X Tags: CNS Neurosci Ther Source Type: research

The age and genomic integrity of neurons after cortical stroke in humans
Nature Neuroscience 17, 801 (2014). doi:10.1038/nn.3706 Authors: Hagen B Huttner, Olaf Bergmann, Mehran Salehpour, Attila Rácz, Jemal Tatarishvili, Emma Lindgren, Tamás Csonka, László Csiba, Tibor Hortobágyi, Gábor Méhes, Elisabet Englund, Beata Werne Solnestam, Sofia Zdunek, Christian Scharenberg, Lena Ström, Patrik Ståhl, Benjamin Sigurgeirsson, Andreas Dahl, Stefan Schwab, Göran Possnert, Samuel Bernard, Zaal Kokaia, Olle Lindvall, Joakim Lundeberg & Jonas Frisén It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangeme...
Source: Nature Neuroscience - April 20, 2014 Category: Neuroscience Authors: Hagen B HuttnerOlaf BergmannMehran SalehpourAttila RáczJemal TatarishviliEmma LindgrenTamás CsonkaLászló CsibaTibor HortobágyiGábor MéhesElisabet EnglundBeata Werne SolnestamSofia ZdunekChristian ScharenbergLena StrömPatrik StåhlBenjamin Sigurgei Tags: Brief Communication Source Type: research

Age-specific transcriptional response to stroke
Abstract: Increased age is a major risk factor for stroke incidence and post-ischemic mortality. To develop age-adjusted therapeutic interventions, a clear understanding of the complexity of age-related post-ischemic mechanisms is essential. Transient occlusion of the middle cerebral artery—a model that closely resembles human stroke—was used to induce cerebral infarction in mice of 4 different ages (2, 9, 15, 24 months). By using Illumina cDNA microarrays and quantitative PCR we detected a distinct age-dependent response to stroke involving 350 differentially expressed genes. Our analyses also identified 327 differen...
Source: Neurobiology of Aging - January 15, 2014 Category: Neuroscience Authors: Matthias W. Sieber, Madlen Guenther, Nadine Jaenisch, Daniela Albrecht-Eckardt, Matthias Kohl, Otto W. Witte, Christiane Frahm Tags: Regular Articles Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

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