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Specialty: Cytology
Procedure: Gastroschisis Repair
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Total 85 results found since Jan 2013.
Proteoglycans and Glycosaminoglycans in Central Nervous System Injury
Am J Physiol Cell Physiol. 2022 May 25. doi: 10.1152/ajpcell.00053.2022. Online ahead of print.ABSTRACTThe brain and spinal cord constitute the central nervous system (CNS), which when injured, can be exceedingly devastating. The mechanistic roles of proteoglycans (PGs) and their glycosaminoglycan (GAG) side chains in such injuries have been extensively studied. CNS injury immediately alters endothelial and extracellular matrix (ECM) PGs and GAGs. Subsequently, these alterations contribute to acute injury, post-injury fibrosis, and post-injury repair. These effects are central to the pathophysiology of CNS injury. This rev...
Source: Am J Physiol Cell Ph... - May 25, 2022 Category: Cytology Authors: Noah Siddiqui Kaori Oshima Joseph A Hippensteel Source Type: research
Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy
Cardiol Res Pract. 2022 May 11;2022:6558060. doi: 10.1155/2022/6558060. eCollection 2022.ABSTRACTCardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world's population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting angiogenesis following myocardial damage. Myocardial vascular repair is crucial for improving myocardial infarction prognosis. Endothelial cells, the largest population of nonmyocytes within myocardial tissue, play an important role ...
Source: Cell Research - May 23, 2022 Category: Cytology Authors: Mingyue Wu Zixia Huang Lijin Zeng Chunfei Wang Deming Wang Source Type: research
Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice
In conclusion, the present study reported the specific changes of ceRNAs in distinct compensatory regions potentially involved in the evolution of cerebral ischemic tissues and the unbalance prognosis after stroke. It provided more evidence for the collateral compensatory effects on patients' prognosis and carried out the new targets for the ischemic stroke therapy.PMID:35449428 | DOI:10.1007/s10571-022-01220-9
Source: Cellular and Molecular Neurobiology - April 22, 2022 Category: Cytology Authors: Jiankun Zang Xionglin Tang Xuanlin Su Tianyuan Zhang Dan Lu Anding Xu Source Type: research
Statins and hearing
Hear Res. 2022 Jan 31:108453. doi: 10.1016/j.heares.2022.108453. Online ahead of print.ABSTRACTStatins are a class of drugs that are widely used for the treatment of hyperlipidemia and the prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the synthesis of cholesterol, HMG-CoA reductase. In addition, statins have effects unrelated to cholesterol, stemming from the non-cholesterol synthesizing arms of the HMG-CoA reductase pathway and the regulation of gene expression. In multiple studies, depending on the cell type and type of statin, statins have been shown to increase antioxidant activit...
Source: Cell Research - February 7, 2022 Category: Cytology Authors: Donna S Whitlon Source Type: research
COVID-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation
In this study, we have first described the advantages and disadvantages of neuroinflammation in the pathological evolution after IS and summarized the characteristics of neuroinflammation in COVID-19-related stroke. Then, we have discussed the potential benefit of MSC-EVs in the regulation of inflammatory responses after COVID-19-induced ischemic events.PMID:35025001 | PMC:PMC8755896 | DOI:10.1007/s10571-021-01169-1
Source: Cellular and Molecular Neurobiology - January 13, 2022 Category: Cytology Authors: Leyla Norouzi-Barough Amir Asgari Khosroshahi Ali Gorji Fariba Zafari Mohammad Shahverdi Shahraki Sadegh Shirian Source Type: research
Donor-derived vasculature is required to support neocortical cell grafts after stroke
Stem Cell Res. 2021 Dec 24;59:102642. doi: 10.1016/j.scr.2021.102642. Online ahead of print.ABSTRACTNeural precursor cells (NPCs) transplanted into the adult neocortex generate neurons that synaptically integrate with host neurons, supporting the possibility of achieving functional tissue repair. However, poor survival and functional neuronal recovery of transplanted NPCs greatly limits engraftment. Here, we test the hypothesis that combining blood vessel-forming vascular cells with neuronal precursors improves engraftment. By transplanting mixed embryonic neocortical cells into adult mice with neocortical strokes, we show...
Source: Cell Research - December 31, 2021 Category: Cytology Authors: Joanna Krzyspiak Jingqi Yan Hiyaa S Ghosh Basia Galinski Pablo J Lituma Karina Alvina Alexandra Quezada Samantha Kee Marta Gro ńska-Pęski Yi De Tai Kelsey McDermott J Tiago Gon çalves R Suzanne Zukin Daniel A Weiser Pablo E Castillo Kamran Khodakhah Je Source Type: research
IMPROvE-CED Trial: Intracoronary Autologous CD34+ Cell Therapy for Treatment of Coronary Endothelial Dysfunction in Patients With Angina and Non-Obstructive Coronary Arteries
Conclusion: A single IC autologous CD34+ cell infusion was safe and may potentially be an effective disease-modifying therapy for microvascular CED in humans. Clinical Trial Registration: NCT03471611.PMID:34923853 | DOI:10.1161/CIRCRESAHA.121.319644
Source: Cell Research - December 20, 2021 Category: Cytology Authors: Michel T Corban Takumi Toya Diana P Albers Faten Sebaali Bradley Lewis John P Pearce Bois Rajiv Gulati Abhiram Prasad Patricia J Best Malcolm Bell Charanjit Rihal Megha Prasad Ali Ahmad Lilach O Lerman Mary L Solseth Jeffrey L Winters Allan B Dietz Amir L Source Type: research
Insights of Extracellular Vesicles of Mesenchymal Stem Cells: a Prospective Cell-Free Regenerative Medicine for Neurodegenerative Disorders
Mol Neurobiol. 2021 Oct 29. doi: 10.1007/s12035-021-02603-7. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are multipotent, adult stem cells which are found in numerous tissues like the umbilical cord, Wharton's jelly, bone marrow, and adipose tissue. They possess the capacity of self-renewal by dividing and differentiating into various cellular lineages. Their characteristic therapeutic potential exploited so far has made them a desirable candidate in regenerative medicine. Neurodegenerative diseases (NDs) like Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral...
Source: Cell Research - October 29, 2021 Category: Cytology Authors: P Vatsa R Negi U A Ansari V K Khanna A B Pant Source Type: research
Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
CONCLUSION: Our results suggest that scCM promotes angiogenesis and the maturation of newly formed vessels while restoring the BBB function in ischemic conditions. In conclusion, our results highlight the possibility of using EPC-secretome as a therapeutic alternative to promote brain angiogenesis and protect from ischemia-induced vascular leakage.PMID:34702368 | DOI:10.1186/s13287-021-02608-y
Source: Cell Research - October 27, 2021 Category: Cytology Authors: Rodrigo Azevedo Loiola Miguel Garc ía-Gabilondo Alba Grayston Paulina Bugno Agnieszka Kowalska Sophie Duban-Deweer Eleonora Rizzi Johan Hachani Yasuteru Sano Fumitaka Shimizu Takashi Kanda Caroline Mysiorek Maciej Piotr Mazurek Anna Rosell Fabien Gossele Source Type: research
