• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The Role of Statins in the Treatment of Type 2 Diabetes Mellitus: an Update.
Abstract The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. T2DM is associated with both microvascular (neuropathy, nephropathy and retinopathy) and macrovascular complications [coronary artery disease (CAD), stroke, carotid artery disease and peripheral artery disease (PAD)]. Apart from acting on diabetic dyslipidemia, statins were shown to exert beneficial effects on several diabetic complications as well as other cardiovascular (CVD) risk predictors such as endothelial dysfunction, inflammation, oxidative stress, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), me...
Source: Current Pharmaceutical Design - September 12, 2013 Category: Drugs & Pharmacology Authors: Niki Katsiki, Vasilios G Athyros, Asterios Karagiannis, Dimitri P Mikhailidis Tags: Curr Pharm Des Source Type: research

Statins influence long term restenosis and cardiovascular events following carotid endarterectomy.
Conclusions: Statins not only reduce cardiovascular events and mortality but may also have an important effect on the anatomic durability of CEA. These data support the use of statins in patients with carotid stenosis undergoing CEA. PMID: 23790064 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - June 17, 2013 Category: Drugs & Pharmacology Authors: Avgerinos ED, Kakisis JD, Moulakakis KG, Giannakopoulos TG, Sfyroeras G, Antonopoulos CN, Kadoglou NP, Liapis CD Tags: Curr Vasc Pharmacol Source Type: research

PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke
Abstract There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti‐inflammatory and vasculoprotective effects, thus contributing to a reduction in infarct size. The underlying mechanisms are still incompletely known. As a cross‐talk between statins and the nuclear receptor PPARα has been described, we hypothesized that this cross‐talk is necessary to neuroprotection in stroke....
Source: Fundamental and Clinical Pharmacology - May 23, 2013 Category: Drugs & Pharmacology Authors: Thavarak Ouk, Camille Potey, Maud Laprais, Sophie Gautier, Rémi Hanf, Raphaël Darteil, Bart Staels, Patrick Duriez, Régis Bordet Tags: Original Article Source Type: research

PPARα is involved in the multi‐targeted effects of a pre‐treatment with atorvastatin in experimental stroke
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - April 1, 2013 Category: Drugs & Pharmacology Authors: Thavarak Ouk, Camille Potey, Maud Laprais, Sophie Gautier, Rémi Hanf, Raphaël Darteil, Bart Staels, Patrick Duriez, Régis Bordet Tags: Original Article Source Type: research

Systematic review and meta-analysis of statin therapy and outcome after ischaemic stroke
Source: Stroke Area: News Data are conflicting regarding the relationship between acute statin therapy and outcome after ischaemic stroke. Some authors have reported improved survival and functional outcome associated with statin treatment, but these findings have not been consistently replicated. Some authors have also reported worse outcomes in patients treated with the combination of acute statins and IV thrombolysis, though these results have not been consistently reproduced. Large randomised trials of acute statin therapy after stroke may resolve these issues, but are expensive and require several years to conduct. M...
Source: NeLM - News - January 10, 2013 Category: Drugs & Pharmacology Source Type: news

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15