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TMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis
J Proteomics. 2023 Jan 13:104820. doi: 10.1016/j.jprot.2023.104820. Online ahead of print.ABSTRACTCVST is a type of venous stroke that mainly affects young adults with no reliable diagnostic markers and effective treatment strategies for secondary pathologies. However, the underlying pathological molecular mechanisms remain unclear. Here, we systematically analyzed the molecule profiling of the cerebrospinal fluid (CSF) in CVST patients via tandem mass tag (TMT)-based proteomics for the first time, aiming to reveal the pathogenesis and provide evidence for the diagnosis and treatment of CVST. Five CVST patients and five co...
Source: Journal of Proteomics - January 16, 2023 Category: Biochemistry Authors: Yaqi Liu Rui Ding Meng Li Weiyang Ou Xifang Zhang Weijie Yang Xiaofei Huang Huihui Chai Qiujing Wang Source Type: research

Clinical Value of Combined Detection of UA and MMP-9 in Evaluating Bleeding Transformation and Prognosis After Thrombolysis in Acute Cerebral Infarction
Appl Biochem Biotechnol. 2022 Jun 21. doi: 10.1007/s12010-022-03990-w. Online ahead of print.ABSTRACTThis paper presents an in-depth study and analysis of the assessment of hemorrhagic transformation and prognostic outcome after thrombolysis in acute cerebral infarction using a combined test and evaluates its clinical value. The ischemic tissue hemodynamic changes were compared and analyzed by the combined application of magnetic resonance conventional examination. Single-factor and multi-factor Logistic regression analysis was applied to the model group samples to determine the independent influencing factors of hemorrhag...
Source: Applied Biochemistry and Biotechnology - June 21, 2022 Category: Biochemistry Authors: Yaming Fu Shuihong Zheng Huimei Kong Mingqiao Ying Hongfang Chen Jianwei Wang Xiaobo Yuan Source Type: research