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Updating contextualized clinical practice guidelines on stroke rehabilitation and low back pain management using a novel assessment framework that standardizes decisions
Conclusions: The updating tool provides a simple, standard and novel approach that incorporates evidence hierarchy and quality, and wordings of recommendations. It could be used efficiently by other guideline updaters particularly in developing countries, where resources for guideline development and updates are limited. When many people are involved in guideline writing, there is always the possibility of ‘slippage’ in use of wording and interpretation of evidence. The PARM updating tool provides a mechanism for maintaining a standard process for guideline updating processes that can be followed by clinicians with bas...
Source: BMC Research Notes - November 4, 2015 Category: Research Authors: Ephraim GambitoConsuelo Gonzalez-SuarezKaren GrimmerCarolina ValdecañasJanine DizonMa. BeredoMarcelle Zamora Source Type: research

Asthma Management in Sickle Cell Disease.
Abstract Asthma is a common comorbid factor in sickle cell disease (SCD). However, the incidence of asthma in SCD is much higher than expected compared to rates in the general population. Whether "asthma" in SCD is purely related to genetic and environmental factors or rather is the consequence of the underlying hemolytic and inflammatory state is a topic of recent debate. Regardless of the etiology, hypoxemia induced by bronchoconstriction and inflammation associated with asthma exacerbations will contribute to a cycle of sickling and subsequent complications of SCD. Recent studies confirm that asthma predisposes...
Source: Biomed Res - December 14, 2013 Category: Research Authors: Gomez E, Morris CR Tags: Biomed Res Int Source Type: research

Delirium in the elderly: Current problems with increasing geriatric age.
Abstract Delirium is an acute disorder of attention and cognition seen relatively commonly in people aged 65 yr or older. The prevalence is estimated to be between 11 and 42 per cent for elderly patients on medical wards. The prevalence is also high in nursing homes and long term care (LTC) facilities. The consequences of delirium could be significant such as an increase in mortality in the hospital, long-term cognitive decline, loss of autonomy and increased risk to be institutionalized. Despite being a common condition, it remains under-recognised, poorly understood and not adequately managed. Advanced age and d...
Source: Indian J Med Res - December 1, 2015 Category: Research Authors: Kukreja D, Günther U, Popp J Tags: Indian J Med Res Source Type: research

Perspective on Broad-Acting Clinical Physiological Effects of Photobiomodulation.
Authors: Shanks S, Leisman G Abstract Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical conditions and illnesses. Although it has become more widely accepted by the mainstream medicine, the effects and mechanisms of action appear to be poorly understood. The therapeutic benefits of photobiomodulation using low-energy red lasers extend far beyond superficial applications, with a well-described physics allowing an understanding of how red lasers of certain optimum intensities may cross the cranium. We now have a model for explaining potential therapeu...
Source: Advances in Experimental Medicine and Biology - March 27, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research