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Total 914 results found since Jan 2013.

GSE158313 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade III
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in ...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

GSE158312 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade II
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE158311 Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade I
Contributors : Katarzyna Winek ; Sebastian Lobentanzer ; Hermona SoreqSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAfter ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post...
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE189432 Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
Contributors : Carolin Beuker ; David Schafflick ; Jan-Kolja Strecker ; Michael Heming ; Gerd Meyer zu H örste ; Jens MinnerupSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the post-ischemic immune response of border compartments compared to brain parenchyma remains poorly characterized .Here, we deeply characterize tissue-resident leukocytes in meninges and brain pare...
Source: GEO: Gene Expression Omnibus - November 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population
Conclusion: Our results demonstrate that DNA methylation plays a crucial part in ischemic stroke. The methylation of these 7 genes may be potential diagnostic biomarker for ischemic stroke.
Source: Frontiers in Genetics - April 11, 2022 Category: Genetics & Stem Cells Source Type: research

Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy
Conclusions Together, these results emphasized the necessity of genotype-directed antiplatelet therapy and facilitated to minimize adverse ischemic events.
Source: Pharmacogenetics and Genomics - May 13, 2022 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

GSE163752 RNAseq dataset of murine NVU cells post ischemic stroke isolated using the SGD method from the same starting material.
Contributors : Devraj Kavi ; G ünther StefanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe blood-brain barier (BBB) function is impaired in several neurological diseases such as stroke. To better study the BBB dysfunction in stroke and to identify novel therapeutic targets, a detailed analysis of the neurovascular unit (NVU) cells that together regulate the BBB function is needed. To this end, we isolated the NVU cells EC, PC, AC, MG post stroke in mice using our newly developed SGD (Spitzer, Gu érit, Devraj) method from the same starting material followed by RNA sequencing. Ce...
Source: GEO: Gene Expression Omnibus - July 20, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Genetic Predisposition to Severe COVID-19 Might Increase the Risk of Stroke: A Two-Sample Mendelian Randomization Study
Conclusion: In summary, this study showed that severe COVID-19 might increase the risk of stroke, thus much more attention should be paid to patients with severe COVID-19.
Source: Frontiers in Genetics - August 12, 2022 Category: Genetics & Stem Cells Source Type: research

Mechanistic and therapeutic role of Drp1 in the pathogenesis of Stroke
Gene. 2022 Dec 18:147130. doi: 10.1016/j.gene.2022.147130. Online ahead of print.ABSTRACTStroke had emerged as one of the leading causes of death and long-term disability across the globe. Emerging evidence suggests a significant increase in the incidence of stroke with age, which is further expected to increase dramatically owing to an ever-expanding elderly population. The current situation imposes a significant burden on the healthcare system and requires a deeper understanding of the underlying mechanisms and development of novel interventions. It is well established that mitochondrial dysfunction plays a pivotal role ...
Source: Gene - December 21, 2022 Category: Genetics & Stem Cells Authors: Himaja Pegadraju Joshua Abby Thomas Rahul Kumar Source Type: research

Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin.
In conclusion, in Chinese patients with ischemic stroke and treated with aspirin, CC genotype of rs1330344 may increase the risk of subsequent vascular events. PMID: 24930730 [PubMed - as supplied by publisher]
Source: Gene - June 12, 2014 Category: Genetics & Stem Cells Authors: Cao L, Zhang Z, Sun W, Bai W, Sun W, Zhang Y, Wang X, Cai B, Xie X, Duan Z, Cai Q, Liu D, Xiong Y, Ma M, Liu X, Xu G Tags: Gene Source Type: research

Are ALOX5AP gene SNPs a risk or protective factor for Stroke?
Abstract ALOX5AP (5-lipoxygenase) has been recognized as a susceptibility gene for stroke. Using a case-control design, the whole coding and adjoining intronic regions of ALOX5AP was sequenced to study the role of SNPs and their interplay with other risk factors in Greek patients with stroke. Patients (n=213) were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Their mean age of was 58.9±14.64, comprising 145 males. The control group consisted of 210 subjects, ethnicity, sex and age matched, with no stroke history. Risk factors (hyperlipidemia, hypertension, atrial fibrillation, migraine, ...
Source: Gene - July 7, 2014 Category: Genetics & Stem Cells Authors: Papapostolou A, Spengos K, Fylaktou I, Poulou M, Gountas I, Kitsiou-Tzeli S, Kanavakis E, Tzetis M Tags: Gene Source Type: research

Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese
Conclusions: The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke.
Source: BMC Medical Genetics - Latest articles - July 17, 2014 Category: Genetics & Stem Cells Authors: Shuzhen GuYan SunRuifa HanLin WangDongliang WangJizuo WangXin Li Source Type: research

PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats.
Authors: Gautier S, Ouk T, Pétrault M, Pétrault O, Bérézowski V, Bordet R Abstract The impact of fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist, on the risk of thrombolysis-induced hemorrhage during the acute phase of stroke in a rat model of stroke was studied. One-hour middle cerebral artery occlusion followed by thrombolysis with tissue plasminogen activator was made in rats receiving either fenofibrate or vehicle for 72 h after stroke. Evaluation of infarct, hemorrhage, middle cerebral artery vasoreactivity, and immunochemistry (CD11b for microglial activation, myelopero...
Source: PPAR Research - June 26, 2015 Category: Genetics & Stem Cells Tags: PPAR Res Source Type: research

GSE66724 Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Contributors : Mikel Allende ; José HermidaSeries Type : Expression profiling by arrayOrganism : Homo sapiensAtrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administered. Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. HSPA1B, which encodes for heat-shock ...
Source: GEO: Gene Expression Omnibus - April 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population
ConclusionsThe results obtained in the present study indicate a potential association between ZNF208 variants and the risk of ischemic risk in a southern Chinese Han population.
Source: The Journal of Gene Medicine - January 31, 2017 Category: Genetics & Stem Cells Authors: Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu Tags: RESEARCH ARTICLE Source Type: research