Filtered By:
Specialty: Genetics & Stem Cells

This page shows you your search results in order of relevance. This is page number 19.

Order by Relevance | Date

Total 914 results found since Jan 2013.

GSE95853 Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke
Conclusions: These studies provide further evidence for HSPCs as a promising therapeutic strategy in promoting repair following cerebral I/RI, potentially via a MT-1 mechanism.
Source: GEO: Gene Expression Omnibus - February 21, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE85299 miRNAs affected in peripheral blood CD34+ cells by stroke
Contributor : Sezin AdaySeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo understand the differentially expressed miRNAs in the peripheral blood CD34+ cells after stroke (first 24 hours after symptom onset), we have employed mRNA sequencing. Among 45 patients included in the study, 6 patients were chosen depending on the clinical outcome (3 patients with "good" and 3 patients with "bad" clinical outcome after 3 months). Immediately after the collection of the peripheral blood from the patients, mononuclear cells (MNCs) were isolated by density centrifugation. Then, CD34+ cells we...
Source: GEO: Gene Expression Omnibus - August 2, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

Coenzyme Q10 deficiency due to a COQ4 gene defect causes childhood-onset spinocerebellar ataxia and stroke-like episodes
We report on a new phenotype of COQ4 deficiency: a childhood onset spinocerebellar ataxia with stroke-like episodes.
Source: Molecular Genetics and Metabolism Reports - September 13, 2018 Category: Genetics & Stem Cells Source Type: research

GSE117064 Serum miRNA-based risk prediction for stroke
Contributors : Takumi Sonoda ; Juntaro Matsuzaki ; Yusuke Yamamoto ; Yoshiaki Aoki ; Satoko Takizawa ; Shumpei Niida ; Takahiro OchiyaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThe serum miRNAs were correlated with predicted the incidence of stroke.
Source: GEO: Gene Expression Omnibus - May 31, 2019 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

A 'stroke' of genius: celebrating the 20-year anniversary of the Bernard Sanberg Memorial Award for Brain Repair.
PMID: 31464568 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - August 28, 2019 Category: Genetics & Stem Cells Authors: Sanberg PR, Sanberg CD Tags: Regen Med Source Type: research

Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in ...
Source: BMC Medical Genetics - September 11, 2019 Category: Genetics & Stem Cells Authors: Yuan Wu, Junjie Zhao, Yonglin Zhao, Tingqin Huang, Xudong Ma, Honggang Pang and Ming Zhang Tags: Research article Source Type: research

GSE146882 Altered lncRNAs transcriptomic profiles in atherosclerosis-induced ischemic stroke
This study identified selective delncRNAs through microarray detection and validated by in vitro cell experiment. Our findings suggest that the ubiquitinated proteasome pathway, VPS13B and BLVRB may play a fundamental role in the pathological process of AIIS.
Source: GEO: Gene Expression Omnibus - March 13, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

Identification micro-RNAs functional modules and genes of ischemic stroke based on weighted gene co-expression network analysis (WGCNA).
PMID: 32198065 [PubMed - as supplied by publisher]
Source: Genomics - March 16, 2020 Category: Genetics & Stem Cells Authors: Pu L, Wang M, Li K, Feng T, Zheng P, Li S, Yao Y, Jin L Tags: Genomics Source Type: research

Identification of novel biomarkers in ischemic stroke: a genome-wide integrated analysis
Ischemic Stroke (IS) is the most common neurological emergency disease and has become the second most frequent cause of death after coronary artery disease in 2015. Owing to its high fatality rate and narrow t...
Source: BMC Medical Genetics - March 30, 2020 Category: Genetics & Stem Cells Authors: Qizhi Xie, Xiaoyun Zhang, Sijia Peng, Jingjing Sun, Xiao Chen, Yuanfei Deng and Li Yi Tags: Research article Source Type: research

GSE152871 Gene expression profiles in microglia with or without PGC-1 α overexpression after acute ischemic stroke (AIS)
Contributors : Bin Han ; Junwei HaoSeries Type : Expression profiling by arrayOrganism : Mus musculusPGC-1 α overexpression in microglia protects against ischemia-induced brain damage in mice. To investigate the underlying mechanism of PGC-1α, we have employed whole mRNA microarray expression profiling as a discovery platform to identify genes with the potential to change the microglial function. Indee d, PGC-1α overexpression alters the gene expression profiles of microglia after AIS, this suggested that microglial PGC-1α might play an important role after ischemic stroke.
Source: GEO: Gene Expression Omnibus - June 20, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Genetic Etiology Shared by Multiple Sclerosis and Ischemic Stroke
Although dramatic progress has been achieved in the understanding and treatment of multiple sclerosis (MS) and ischemic stroke (IS), more precise and instructive support is required for further research. Recent large-scale genome-wide association studies (GWASs) have already revealed risk variants for IS and MS, but the common genetic etiology between MS and IS remains an unresolved issue. This research was designed to overlapping genes between MS and IS and unmask their transcriptional features. We designed a three-section analysis process. Firstly, we computed gene-based analyses of MS GWAS and IS GWAS data sets by VGEAS...
Source: Frontiers in Genetics - July 2, 2020 Category: Genetics & Stem Cells Source Type: research

A novel CACNA1A variant in a child with early stroke and intractable epilepsy
ConclusionWe present the second case of recurrent ischemic strokes in a patient withCACNA1A mutation. Our findings expand the phenotypic heterogeneity related to Cav2.1 (P/Q‐type) calcium channel dysfunction and suggest consideration ofCACNA1A disorder in evaluation of pediatric strokes.
Source: Molecular Genetics & Genomic Medicine - July 20, 2020 Category: Genetics & Stem Cells Authors: Franciska J. Gudenkauf, Mahshid S. Azamian, Jill V. Hunter, Anuranjita Nayak, Seema R. Lalani Tags: CLINICAL REPORT Source Type: research

MYORG gene disease-causing variants in a family with primary familial brain calcification presenting with stroke-like episodes.
PMID: 32896900 [PubMed - as supplied by publisher]
Source: Clinical Genetics - September 7, 2020 Category: Genetics & Stem Cells Authors: Malaquias MJ, Martins RC, Oliveira J, Freixo JP, Magalhães M Tags: Clin Genet Source Type: research

GSE166791 Gene expression profiles in microglia with or without VDR elimination after experimental ischemic stroke
Contributors : P Cui ; Fang Xu ; Xiaodan Hou ; Junwei HaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia-specific VDR deletion markedly aggravates neurological deficits after cerebral ischemia. In particular, VDR-deleted microglia exhibited a more primed proinflammatory phenotype. To investigate the role of microglial VDR in the pathophysiological processes after cerebral ischemia, we isolated microglia from poststroke microglia-conditional VDR knockout (VDR-cKO) mice and VDRflox littermate controls, and employed RNA Sequencing analysis. Indeed, VDR elimination alters the ge...
Source: GEO: Gene Expression Omnibus - February 16, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE168383 A neuroprotective locus modulates ischemic stroke infarction independent of collateral vessel anatomy
Contributors : Han K Lee ; Sarah E Wetzel-Strong ; David L Aylor ; Douglas A MarchukSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe strains, C57BL6/J, C3H/HeJ, and WSB/EiJ, show a similar collateral vessel anatomy but differ infarct volume after ischemic stroke induction. To identify a gene(s) exhibiting differential gene expression, we performed RNA seq experiment within these mouse strains.
Source: GEO: Gene Expression Omnibus - March 6, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research