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Specialty: Epidemiology

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Total 1093 results found since Jan 2013.

Sex differences in clinical characteristics and outcomes after intracerebral haemorrhage: results from a 12-month prospective stroke registry in Nanjing, China
This study aimed to investigate the sex differences in clinical characteristics, severity and outcomes of Chinese ICH patients. Methods: The Nanjing First Hospital stroke registry was a hospital-based registry of stroke patients with 1-year prospective follow-up. From 2004 to 2008, a total of 651 consecutively recruited patients with acute ICH were enrolled. Primary outcome was death or dependency defined as a modified Rankin Scale score of 3?6 at 12 months. Multivariable logistic regression analyses were performed to determine whether there were sex differences in clinical outcomes after ICH. Clinically important and biol...
Source: Epidemiologic Perspectives and Innovations - September 4, 2014 Category: Epidemiology Authors: Junshan ZhouYingdong ZhangHisatomi ArimaYanxia ZhaoHongdong ZhaoDanni ZhengYouyong TianYukai LiuQing HuangJie Yang Source Type: research

Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis
Abstract Subclinical thyroid dysfunction has been associated with coronary heart disease, but the risk of stroke is unclear. Our aim is to combine the evidence on the association between subclinical thyroid dysfunction and the risk of stroke in prospective cohort studies. We searched Medline (OvidSP), Embase, Web-of-Science, Pubmed Publisher, Cochrane and Google Scholar from inception to November 2013 using a cohort filter, but without language restriction or other limitations. Reference lists of articles were searched. Two independent reviewers screened articles according to pre-specified criteria and selected pr...
Source: European Journal of Epidemiology - September 2, 2014 Category: Epidemiology Source Type: research

Development of a computerised decision aid for thrombolysis in acute stroke care
Conclusions: Our structured development process led to the development of a gamma prototype computerised decision aid. Initial evaluation has demonstrated reasonable acceptability of COMPASS amongst patients, relatives and clinicians. The impact of COMPASS on clinical outcomes requires wider prospective evaluation in clinical settings.
Source: Epidemiologic Perspectives and Innovations - February 7, 2015 Category: Epidemiology Authors: Darren FlynnDaniel J NesbittGary A FordPeter McMeekinHelen RodgersChristopher PriceChristian KrayRichard G Thomson Source Type: research

Stroke-Risk Factors Differ between Rural and Urban Communities: Population Survey in Central Uganda
This study assessed stroke-risk factors and their associated characteristics in urban and rural Uganda. Methods: We surveyed 5,420 urban and rural participants and assessed the stroke-risk factor prevalence and socio-behavioural characteristics associated with risk factors. Results: Rural participants were older with higher proportions of men and fewer poor compared to urban areas. The most prevalent modifiable stroke-risk factors in all areas were hypertension (27.1% rural and 22.4% urban, p = 0.004), overweight and obesity (22.0% rural and 42% urban, p
Source: Neuroepidemiology - May 6, 2015 Category: Epidemiology Source Type: research

Cross-cultural adaptation of the stroke action test for Italian- speaking people
Conclusions: The process used to perform the cross-cultural adaptation of the questionnaire was successful. The Italian version of STAT demonstrated good acceptability and psychometric properties and is now available to assess stroke awareness in Italian people.
Source: Epidemiologic Perspectives and Innovations - May 9, 2015 Category: Epidemiology Authors: Licia DentiBarbara MarcominiSilvia RivaPeter SchulzCaterina Caminitifor EROI (Educazione e Ritardo di Ospedalizzazione per Ictus) study group Source Type: research

Are Early Seizures Predictive of Epilepsy after a Stroke? Results of a Population-Based Study
This study was part of a 2-year prospective community-based registry of all cerebrovascular events in the district of Udine (153,312 inhabitants), North-Eastern Italy, between April 1, 2007 and March 31, 2009. People with transient ischemic attacks (TIAs) were excluded from this study. Results: In all, 782 cases of stroke (79.28% ischemic, 14.83% hemorrhagic, 3.20% subarachnoid hemorrhage and 2.69% undetermined) were identified. The incidence of ES, LS and PSE was 5.10, 3.14 and 2.22%, respectively. Intracerebral hemorrhage, subarachnoid hemorrhage, stroke of undetermined origin and hyponatremia, represented risk factors for ES (p
Source: Neuroepidemiology - July 27, 2015 Category: Epidemiology Source Type: research

Are Early Seizures Predictive of Epilepsy after a Stroke Results of a Population-Based Study
This study was part of a 2-year prospective community-based registry of all cerebrovascular events in the district of Udine (153,312 inhabitants), North-Eastern Italy, between April 1, 2007 and March 31, 2009. People with transient ischemic attacks (TIAs) were excluded from this study. Results: In all, 782 cases of stroke (79.28% ischemic, 14.83% hemorrhagic, 3.20% subarachnoid hemorrhage and 2.69% undetermined) were identified. The incidence of ES, LS and PSE was 5.10, 3.14 and 2.22%, respectively. Intracerebral hemorrhage, subarachnoid hemorrhage, stroke of undetermined origin and hyponatremia, represented risk factors for ES (p
Source: Neuroepidemiology - July 28, 2015 Category: Epidemiology Source Type: research

From Data to Action: Neuroepidemiology Informs Implementation Research for Global Stroke Prevention and Treatment
As a scientific field of study, neuroepidemiology encompasses more than just the descriptive study of the frequency, distribution, determinants and outcomes of neurologic diseases in populations. It also includes experimental aspects that span the full spectrum of clinical and population science research. As such, neuroepidemiology has a strong potential to inform implementation research for global stroke prevention and treatment. This review begins with an overview of the progress that has been made in descriptive and experimental neuroepidemiology over the past quarter century with emphasis on standards for evidence gene...
Source: Neuroepidemiology - October 30, 2015 Category: Epidemiology Source Type: research

Gender and stroke in Brazzaville.
CONCLUSION: Our study suggests that in the Congolese context, gender does not influence significantly most parameters during stroke, but men consume more alcohol and women are exposed to psychosocial stress. PMID: 24387863 [PubMed - indexed for MEDLINE]
Source: Revue d Epidemiologie et de Sante Publique - November 19, 2015 Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research

Sex Differences Do Not Exist in Outcomes among Stroke Patients with Intracranial Atherosclerosis in China: Subgroup Analysis from the Chinese Intracranial Atherosclerosis Study
Conclusions: These results suggest no sex difference in outcome among patients with ICAS in Chinese cerebral ischemia patients.Neuroepidemiology 2017;48:48-54
Source: Neuroepidemiology - March 23, 2017 Category: Epidemiology Source Type: research

Hypothetical interventions to prevent stroke: an application of the parametric g-formula to a healthy middle-aged population
AbstractThe effects of interventions on multiple lifestyle and metabolic risk factors, initiated in midlife or later in a healthy population, on the long-term risk of first-ever stroke is not known. A particular methodological challenge in observational studies is to estimate the unbiased effect of a time-varying exposure in presence of time-varying confounders, if those confounders are affected by prior exposure. In such cases, the parametric g-formula can be applied to estimate an unbiased effect. We applied the parametric g-formula to estimate the 18-years (1994 –2012) cumulative stroke risk under different scenarios ...
Source: European Journal of Epidemiology - January 2, 2018 Category: Epidemiology Source Type: research

Analysis of Hospital Charges of Inpatients with Acute Ischemic Stroke in Beijing, China, 2012 –2015
Conclusions: The proportion of medicine fees for the ischemic stroke inpatients showed a downward trend during the period from 2012 to 2015, but medicine fees still accounted for the largest percentage of hospital charges in China. LOHS emerged to be the main determinant of the cost. Decreasing medicine fees and LOHS might be strategies to decrease hospital charges and reduce economic burden of stroke in China.Neuroepidemiology 2018;50:63 –73
Source: Neuroepidemiology - February 8, 2018 Category: Epidemiology Source Type: research

Differential Susceptibility in Ambient Particle –Related Risk of First-Ever Stroke: Findings From a National Case-Crossover Study
AbstractDifferent populations may respond differently to exposure to ambient fine particulate matter, defined as particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5); however, less is known about the distribution of susceptible individuals among the entire population. We conducted a time-stratified case-crossover study to assess associations between stroke risk and exposure to PM2.5. During 2013 –2015, 1,356 first-ever stroke events were derived from a large representative sample, the China National Stroke Screening Survey (CNSSS) database. Daily PM2.5 average exposures with a spatial res...
Source: American Journal of Epidemiology - January 17, 2018 Category: Epidemiology Source Type: research

Risk of Hemorrhagic Stroke in Patients Exposed to Nonsteroidal Anti-Inflammatory Drugs: A Meta-Analysis of Observational Studies
Conclusion: Our results indicated that the use of NSAIDs is significantly associated with a higher risk of developing hemorrhagic stroke. These results should be interpreted with caution because they may be confounded owing to the observational design of the individual studies. Nevertheless, we recommend that NSAIDs should be used judiciously, and their efficacy and safety should be monitored proactively.Neuroepidemiology 2018;51:166 –176
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Integrated analysis of the proteome and transcriptome in a MCAO mouse model revealed the molecular landscape during stroke progression.
Abstract Strokes usually results in long-term disability and death, and they occur worldwide. Recently, increased research on both on the physiopathological mechanisms and the transcriptome during stroke progression, have highlighted the relationship between stroke progression and immunity, with a special focus on inflammation. Here, we applied proteome analysis to a middle carotid artery occlusion (MCAO) mouse model at 0 h, 6 h, 12 h and 24 h, in which proteome profiling was performed with 23 samples, and 41 differentially expressed proteins (DEPs) were identified. Bioinformatics studies on our data revealed ...
Source: Adv Data - March 19, 2020 Category: Epidemiology Authors: Li L, Dong L, Xiao Z, He W, Zhao J, Pan H, Chu B, Cheng J, Wang H Tags: J Adv Res Source Type: research