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Specialty: Biomedical Science
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Total 2301 results found since Jan 2013.
Prediction of recurrent stroke among ischemic stroke patients with atrial fibrillation: Development and validation of a risk score model
ConclusionsNeither conventional risk stratification tools nor our newly developed comprehensive prediction model using available clinical factors seemed to be suitable for identifying patients at high risk of recurrent ischemic stroke among AIS patients with AF in this modern direct oral anticoagulant era. Detailed individual information, including imaging, may be warranted to build a more robust and precise risk prediction model for stroke survivors with AF.
Source: PLoS One - October 8, 2021 Category: Biomedical Science Authors: Beom Joon Kim Source Type: research
Near-infrared spectroscopy as a promising tool in stroke: Current applications and future perspectives
Journal of Innovative Optical Health Sciences, Ahead of Print. Stroke is caused by an acute focal disruption of the vasculature in the central nervous system. Neurological-related functional deficits are the most devastating consequences for stroke survivors. Neural signals from stroke patients can reflect the functional statuses of patients and provide insights into the neuronal recovery mechanism for functioning, which could be used as the basis for designing optimal treatment strategies. Near-infrared spectroscopy (NIRS) is a low-cost, noninvasive, easily operated neuroimage method and it is compatible with various reha...
Source: Journal of Innovative Optical Health Sciences - October 25, 2021 Category: Biomedical Science Authors: Jinyan Sun Richong Pang Sisi Chen Hucheng Chen Yuanrong Xie Dandan Chen Kai Wu Jianbin Liang Kecheng Yan Zhifeng Hao Source Type: research
Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials
ConclusionThe prognosis of patients with an ischemic stroke or transient ischemic attack is improved with antiplatelets. Cilostazol showed the best risk-benefit characteristics without trade-off with the risk of major bleeding. Improved stroke recurrence with intensified antiplatelet regimens is counterbalanced with higher bleeding risk, and consequently, mortality remains unaffected. Treatment decisions in stroke survivals should integrate the assessment of bleeding risk for better identification of patients with the highest benefit of treatment intensification. Systematic review registrationProspero registration number: ...
Source: PLoS One - August 17, 2022 Category: Biomedical Science Authors: D ániel Tornyos Source Type: research
Body mass index and stroke risk among patients with diabetes mellitus in Korea
ConclusionBMI was positively associated with the overall risk of stroke among DM patients in Korea. The risk of ischemic stroke was higher in obese patients compared to overweight or normal-weight patients. However, the risk of hemorrhagic stroke was higher in slimmer patients compared with overweight or obese patients.
Source: PLoS One - September 30, 2022 Category: Biomedical Science Authors: Do Kyeong Song Source Type: research
Proportion of stroke types in Madagascar: A tertiary-level hospital-based case series
ConclusionsOur study is the first to report the proportion of stroke types and known risk factors in Madagascar. We find that the proportion of hemorrhagic strokes was unexpectedly higher than that reported from other countries in sub-Saharan Africa. Our findings highlight the need for a country-specific approach to stroke prevention, treatment, and rehabilitation and provide guidance on public health resource allocation in Madagascar.
Source: PLoS One - October 14, 2022 Category: Biomedical Science Authors: Julia Riedmann Source Type: research
Scoping review of molecular biomarkers associated with fatigue, stress, and depression in stroke survivors: A protocol
by Tarynn Potter, Nisal Gange, Eliza Whiteside, Prajwal Gyawali
The prevalence of stroke increases each year and while mortality from stroke has decreased, the prevalence of comorbidities such as anxiety, depression and fatigue affects as many as 75% of stroke survivors. The aetiology of post-stroke fatigue is not clear, although it has been shown to be interr elated with comorbidities such as stress and depression. Due to the interconnected nature of these comorbidities, it is important to improve the specificity of diagnosis and identify novel therapeutic targets to improve the quality of life for stroke survivors. The ...
Source: PLoS One - February 3, 2023 Category: Biomedical Science Authors: Tarynn Potter Source Type: research
Identification of key biomarkers in ischemic stroke: single-cell sequencing and weighted co-expression network analysis
CONCLUSIONS: Our study provides a reference for the study of pathogenesis and key targets of ischemic stroke.PMID:37418282 | DOI:10.18632/aging.204855
Source: Aging - July 7, 2023 Category: Biomedical Science Authors: Jiali Tao Xiaochen Xie Man Luo Qingsong Sun Source Type: research
Are digital social media campaigns the key to raise stroke awareness in low-and middle-income countries? A study of feasibility and cost-effectiveness in Nepal
This study aims to (a) explore the feasibility of a social media-based stroke awareness campaign in Nepal using a cost-benefit analysis and (b) identify best practices for social media health education campaigns. MethodsWe performed a stroke awareness campaign over a period of 6 months as part of a Stroke Project in Nepal on four social media platforms (Facebook, Instagram, Twitter, TikTok) with organic traffic and paid advertisements. Adapted material based on the World Stroke Day Campaign and specifically created videos for TikTok were used. Performance of the campaign was analyzed with established quantitative social me...
Source: PLoS One - September 8, 2023 Category: Biomedical Science Authors: Christine Tunkl Source Type: research
Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model
Small non-coding RNA (miRNA) found in circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex on microRNA expression following ischemic stroke in an animal model. Adult (6 month) and middle-aged (11-12 months) female and male rats were subject to middle cerebral artery occlusion (MCAo) using endothelin-1. Circulating miRNAs were analyzed in blood samples at 2 days and 5 days post stroke, while brain miRNA were analyzed at 5 days post stroke. While stroke-associated infarction is seen in all groups, infarct volume a...
Source: Clinical Science - January 15, 2014 Category: Biomedical Science Authors: A Selvamani, M H Williams, R C Miranda, F Sohrabji Source Type: research
Measures of Abdominal Adiposity and Risk of Stroke: A Dose-Response Meta-analysis of Prospective Studies.
CONCLUSION: Findings from our meta-analysis indicated that waist circumference, waist-to-hip ratio, and waist-to-height ratio were positively associated with the risk of stroke, particularly ischemic stroke.
PMID: 26822509 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - January 1, 2016 Category: Biomedical Science Authors: Zhong CK, Zhong XY, Xu T, Zhang YH Tags: Biomed Environ Sci Source Type: research
Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice
by Liang Wang, Shuai Kang, Dingquan Zou, Lei Zhan, Zhengxi Li, Wan Zhu, Hua Su
Ischemic stroke is a devastating complication of bone fracture. Bone fracture shortly after stroke enhances stroke injury by augmenting inflammation. We hypothesize that bone fracture shortly before ischemic stroke also exacerbates ischemic cerebral injury. Tibia fracture was performed 6 or 24 hours before permanent middle cerebral artery occlusion (pMCAO) on C57BL/6J mice or Ccr2RFP/+Cx3cr1GFP/+ mice that have the RFP gene knocked into one allele of Ccr2 gene and GFP gene knocked into one allele of Cx3cr1 gene. Behavior was tested 3 days after...
Source: PLoS One - April 17, 2016 Category: Biomedical Science Authors: Liang Wang Source Type: research
Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect
ConclusionThis study is limited by the quantity of data available. Further investigation is warranted, and, as justifying further trials may be difficult, it would be desirable to obtain individual patient level data (IPD) to facilitate an effort to relate treatment effects to IPD covariates in order to investigate heterogeneity. Observational data could also be examined to establish if there are potential trends elsewhere. The approach and methods presented have potentially wide applications within any indication as to highlight the potential benefit of extending decision problems to include additional comparators outside...
Source: PLoS One - August 24, 2016 Category: Biomedical Science Authors: Sarah Batson Source Type: research
The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity
by Xiaodan Wei, Zhuang Liu, Min Li, Chunhua Yang, Wenming Wang, Xianglin Li, Shuping Zhang, Xuri Li, Geng Tian, Jonas Bergquist, Bin Wang, Jia Mi
BackgroundThe severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear. AimsWe aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors. MethodsWe performed a retrospective ana...
Source: PLoS One - September 19, 2016 Category: Biomedical Science Authors: Xiaodan Wei Source Type: research
The Association of Lesion Location and Sleep Related Breathing Disorder in Patients with Acute Ischemic Stroke
ConclusionWe found no association of lesion location and SRBD in stroke patients, whereas established risk factors for SRBD, known from general population, were significantly associated with SRBD. Given the high prevalence of SRBD in stroke patients, these findings suggest that cerebral ischemia facilitates the occurrence of SRBD in patients with pre-existing risk factors rather than causing it by damaging specific central nervous system structures. Our findings can be used to identify stroke patients who might benefit from polygraphy screening.
Source: PLoS One - January 29, 2017 Category: Biomedical Science Authors: Anna Lena Fisse Source Type: research
