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Specialty: Drugs & Pharmacology

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Total 5519 results found since Jan 2013.

Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke
CNS Neurol Disord Drug Targets. 2021 Mar 22. doi: 10.2174/1871527320666210322115808. Online ahead of print.ABSTRACTThe gastrointestinal tract is a major organ for the body to absorb nutrients, water and electrolytes. At the same time, it is a tight barrier to resist the invasion of harmful substances and maintain the homeostasis of the internal environment. Destruction of the intestinal barrier is linked to the digestive system, cardiovascular system, endocrine system and other systemic diseases. Mounting evidence suggests that ischemic stroke not only changes the intestinal microbes, but also increases the permeability of...
Source: CNS and Neurological Disorders Drug Targets - March 22, 2021 Category: Drugs & Pharmacology Authors: Minping Wei Qin Huang Zeyu Liu Yunfang Luo Jian Xia Source Type: research

Ischemic Stroke and Infection: A brief update on mechanisms and potential therapies
Biochem Pharmacol. 2021 Sep 17:114768. doi: 10.1016/j.bcp.2021.114768. Online ahead of print.ABSTRACTIschemic stroke triggers a multifaceted inflammatory response in the brain that contributes to secondary brain injury and infarct expansion. In parallel with brain inflammation, ischemic stroke also leads to post-stroke immunosuppression. Stroke-induced leukopenia then predisposes patients to opportunistic infections potentially leading to pneumonia or unrinary tract infections and a worsened stroke outcome. There is evidence that the hypothalamic-pituitary-adrenal axis plays an important role in the etiology of post-stroke...
Source: Biochemical Pharmacology - September 20, 2021 Category: Drugs & Pharmacology Authors: Drishti P Ghelani Hyun Ah Kim Shenpeng R Zhang Grant R Drummond Christopher G Sobey T Michael De Silva Source Type: research

Angiogenesis-Regulating microRNAs and Ischemic Stroke.
Abstract Stroke is a leading cause of death and disability worldwide. Ischemic stroke is the dominant subtype of stroke and results from focal cerebral ischemia due to occlusion of major cerebral arteries. Thus, the restoration or improvement of reduced regional cerebral blood supply in a timely manner is very critical for improving stroke outcomes and post-stroke functional recovery. The recovery from ischemic stroke largely relies on appropriate restoration of blood flow via angiogenesis. Newly formed vessels would allow increased cerebral blood flow, thus increasing the amount of oxygen and nutrients delivered ...
Source: Current Vascular Pharmacology - May 13, 2013 Category: Drugs & Pharmacology Authors: Yin KJ, Hamblin M, Chen YE Tags: Curr Vasc Pharmacol Source Type: research

Characteristic of drug-related problems and pharmacists ’ interventions in a stroke unit in Thailand
Conclusion DRP in a stroke unit is common. Clinical pharmacists in a stroke unit can effectively reduce and prevent DRPs with the focus on performing medication reconciliation, providing recommendation on dosage adjustment and proper drug selection for stroke patients.
Source: International Journal of Clinical Pharmacy - May 2, 2019 Category: Drugs & Pharmacology Source Type: research