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Specialty: Drugs & Pharmacology
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Total 5519 results found since Jan 2013.
Netrin-1 in Post-stroke Neuroprotection: beyond Axon Guidance Cue
CONCLUSION: There has been certain evidence to support the neuroprotective function of netrin-1 by regulating angiogenesis, autophagy, apoptosis and neuroinflammation after stroke. Netrin-1 may be a promising drug candidate in reducing stroke severity and improving outcome.PMID:35236266 | DOI:10.2174/1570159X20666220302150723
Source: Current Neuropharmacology - March 3, 2022 Category: Drugs & Pharmacology Authors: Ying Luo Songjie Liao Jian Yu Source Type: research
A Network-Based Approach to Investigate the Neuroprotective Effects and Mechanisms of Action of Huangqi-Chuanxiong and Sanleng-Ezhu Herb Pairs in the Treatment of Cerebral Ischemic Stroke
Conclusion: We identified a new treatment formulation for ischemic stroke by data mining and network pharmacological target prediction. The beneficial effects of the new formulation act by regulating multiple target genes and pathways. The mechanism of action of the new formulation may be related to the AKT and ERK signaling pathways. Our findings provide a theoretical basis for the effects of the new formulation on ischemic stroke injury.
Source: Frontiers in Pharmacology - March 23, 2022 Category: Drugs & Pharmacology Source Type: research
Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke
Curr Neuropharmacol. 2022 Jul 6. doi: 10.2174/1570159X20666220706115957. Online ahead of print.ABSTRACTAs the first peripheral immune cells to enter the brain after ischemic stroke, neutrophils are important participants in stroke-related neuroinflammation. Neutrophils are quickly mobilized from the periphery in response to a stroke episode and cross the blood-brain barrier to reach the ischemic brain parenchyma. This process involves the mobilization and activation of neutrophils from peripheral immune organs (including the bone marrow and spleen), their chemotaxis in the peripheral blood, and their infiltration into the ...
Source: Current Neuropharmacology - July 7, 2022 Category: Drugs & Pharmacology Authors: Meizhen Xie Yulei Hao Liangshu Feng Tian Wang Mengyue Yao Hui Li Di Ma Jiachun Feng Source Type: research
Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents
In this study we compared the cell composition of COs at different culture time and explored the cell types, cell ratios and volume size of COs at 85 days (85 d-CO). The 85 d-CO with diameter more than 2 mm was chosen for establishing humanized ischemic stroke model of OGD. By determining the time-injury relationship of the model, we observed aggravated ischemic injury of COs with OGD exposure time, obtaining first-hand evidence for the damage degree of COs under different OGD condition. The sensitivity of the model to ischemic injury and related treatment was validated by the proven pan-Caspase inhibitor Z-VAD-FMK (20 μM...
Source: Acta Pharmacologica Sinica - September 13, 2022 Category: Drugs & Pharmacology Authors: Shu-Na Wang Zhi Wang Xi-Yuan Wang Xiu-Ping Zhang Tian-Ying Xu Chao-Yu Miao Source Type: research
