Filtered By:
Specialty: Chemistry
Nutrition: Diets

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 28 results found since Jan 2013.

Molecules, Vol. 28, Pages 390: Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus
In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 injection; the mice were sacrificed 24 h after ET-1 injection. In another plan, PRE084 treatment was initiated 24 h after ET-1 injection and lasted for 7 d. In the third plan, PRE084 treatme...
Source: Molecules - January 2, 2023 Category: Chemistry Authors: Wenjing Song Yang Yao Heling Zhang Xin Hao Liping Zhou Zhixiao Song Tiantian Wei Tianyan Chi Peng Liu Xuefei Ji Libo Zou Tags: Article Source Type: research

Molecules, Vol. 27, Pages 2484: Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
k Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also be...
Source: Molecules - April 12, 2022 Category: Chemistry Authors: Micha ł Pasierski Bart łomiej Szulczyk Tags: Review Source Type: research

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant Metabolism
This study addressed the effect of genetic variability in developing obesity and the efficacy of the inhibition of cluster of differentiation 36 (CD36), a multifunctional receptor implicated in obesity and insulin resistance, in WT mice and mice with the BDNF Val66Met variant. CD36 inhibition by salvionolic acid B (SAB) in diet-induced obese WT mice reduced visceral fat accumulation and improved insulin resistance. The benefit of SAB was abrogated in CD36 knockout mice, showing the specificity of SAB. In addition, mice with the Val66Met variant in both alleles (BDNFM/M) fed a high-fat diet exhibited extreme obesity with in...
Source: Journal of Biological Chemistry - August 24, 2018 Category: Chemistry Authors: Jiwon Yang, Keun Woo Park, Sunghee Cho Tags: Editors ' Picks Source Type: research

Molecules, Vol. 23, Pages 3305: Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases
azzon N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially avai...
Source: Molecules - December 13, 2018 Category: Chemistry Authors: Giuseppe Tardiolo Placido Bramanti Emanuela Mazzon Tags: Review Source Type: research

Molecules, Vol. 25, Pages 2719: Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects
se This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prev...
Source: Molecules - June 10, 2020 Category: Chemistry Authors: Calabrese Tags: Review Source Type: research

Molecules, Vol. 26, Pages 302: Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice
Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.
Source: Molecules - January 8, 2021 Category: Chemistry Authors: Ahtesham Hussain Jin Sook Cho Jong-Seok Kim Young Ik Lee Tags: Article Source Type: research

Molecules, Vol. 26, Pages 2495: The Role of Resveratrol in Human Male Fertility
do E. Calogero Resveratrol (RSV) (3,4′,5 trihydroxystilbene) is a natural non-flavonoid polyphenol widely present in the Mediterranean diet. In particular, RSV is found in grapes, peanuts, berries, and red wine. Many beneficial effects of this molecule on human health have been reported. In fact, it improves some clinical aspects of various diseases, such as obesity, tumors, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, and diabetes mellitus. However, little is known about the relationship between this compound and male fertility and the few available results are often controversial. Therefore...
Source: Molecules - April 24, 2021 Category: Chemistry Authors: Laura M. Mongio ì Sarah Perelli Rosita A. Condorelli Federica Barbagallo Andrea Crafa Rossella Cannarella Sandro La Vignera Aldo E. Calogero Tags: Review Source Type: research

Bacopa monnieri for disorders affecting brain: Current perspectives
Curr Top Med Chem. 2022 Jan 19. doi: 10.2174/1568026622666220119111538. Online ahead of print.ABSTRACTBacopa monnieri (BM) is of immense therapeutic potential in today's world. This review is aimed to project the beneficial role of BM in disorders affecting the brain, including Alzheimer's disease, Parkinson's disease, stroke, epilepsy and depression. The active constituents and metabolites responsible for the effects of BM could be bacoside A and B, bacopaside I and II, bacopasaponin C, betulinic acid, asiatic acid, loliolide, ebelin lactone and quercetin. The mechanistic role of BM in brain disorders might be related to ...
Source: Current Topics in Medicinal Chemistry - January 19, 2022 Category: Chemistry Authors: Adithya Vinod S Sathianarayanan Anju Elizabath Babu Prashant Sadanandan None Athira K V Baskar Venkidasamy Source Type: research

Molecules, Vol. 27, Pages 1049: Coffee-Derived Phenolic Compounds Activate Nrf2 Antioxidant Pathway in I/R Injury In Vitro Model: A Nutritional Approach Preventing Age Related-Damages
essandra Bulbarelli Age-related injuries are often connected to alterations in redox homeostasis. The imbalance between free radical oxygen species and endogenous antioxidants defenses could be associated with a growing risk of transient ischemic attack and stroke. In this context, a daily supply of dietary antioxidants could counteract oxidative stress occurring during ischemia/reperfusion injury (I/R), preventing brain damage. Here we investigated the potential antioxidant properties of coffee-derived circulating metabolites and a coffee pulp phytoextract, testing their efficacy as ROS scavengers in an in vitro model...
Source: Molecules - February 3, 2022 Category: Chemistry Authors: Elena Lonati Tatiana Carrozzini Ilaria Bruni Pedro Mena Laura Botto Emanuela Cazzaniga Daniele Del Rio Massimo Labra Paola Palestini Alessandra Bulbarelli Tags: Article Source Type: research

Vitamin D and its possible relationship to neuroprotection in COVID-19: evidence in the literature
Curr Top Med Chem. 2022 Apr 1. doi: 10.2174/1568026622666220401140737. Online ahead of print.ABSTRACTVitamin D is a hormone involved in the regulation of important biological processes such as signal transduction, immune response, metabolic regulation and also in the nervous and vascular systems. To date, coronavirus disease 2019 (COVID-19) infection does not have a specific treatment, however various drugs have been proposed, including those that attenuate the intense inflammatory response and recently the use of vitamin D, in clinical trials, as part of the treatment of COVID-19 has provided promising results. It has bee...
Source: Current Topics in Medicinal Chemistry - April 3, 2022 Category: Chemistry Authors: Saray Quintero-Fabi án Cindy Bandala Luz Adriana Pichardo-Mac ías Itzel Jatziri Contreras-Garc ía Sa úl Gómez-Manzo Beatriz Hern ández-Ochoa Jos é Arturo Martínez-Orozco Iv án Ignacio-Mejía Noem í Cárdenas-Rodríguez Source Type: research

Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment
Curr Med Chem. 2022 Apr 8. doi: 10.2174/0929867329666220408102051. Online ahead of print.ABSTRACTDementia and frailty increase health adversities in older adults, which are topics of growing research interest. Frailty is considered to correspond to a biological syndrome associated with age. Frail patients may ultimately develop multiple dysfunctions across several systems, including stroke, transient ischemic attack, vascular dementia, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, cortico-basal degeneration, multiple system atrophy, amyotrophic lateral sclerosis, and Creutzfe...
Source: Current Medicinal Chemistry - April 11, 2022 Category: Chemistry Authors: Md Mominur Rahman Sadia Afsana Mim Md Rezaul Islam Anwar Parvez Fahadul Islam Mohammad Borhan Uddin Md Saidur Rahaman Pollob Ahmed Shuvo Muniruddin Ahmed Nigel H Greig Mohammad Amjad Kamal Source Type: research